Skip to main content
PMC home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1987 Mar;67(3):500–506.

A cross-reactive idiotype on anti-DNA and lymphocytotoxic antibodies.

P M Lydyard, D Isenberg, B de Sousa, L Mackenzie, A Cooke
PMCID: PMC1542638  PMID: 2440630

Abstract

The possibility that shared idiotypes may be present on antibodies of different specificities was explored using sera from 13 patients with systemic lupus erythematosus. Eleven sera had anti-DNA and seven carried the 16/6 idiotype (ID). Two of the sera with 16/6 ID also had lymphocytotoxic antibodies, the activity of which was blocked by antibody to the 16/6 ID. Our studies reveal that 16/6 ID is present on two antibodies with different binding specificities.

Full text

PDF
501

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Altevogt P., Wigzell H. A VH-associated idiotype in human anti-tetanus antibodies. Scand J Immunol. 1983 Feb;17(2):183–192. doi: 10.1111/j.1365-3083.1983.tb00781.x. [DOI] [PubMed] [Google Scholar]
  2. Bottomly K. 1984: all idiotypes are equal, but some are more equal than others. Immunol Rev. 1984 Jun;79:45–61. doi: 10.1111/j.1600-065x.1984.tb00486.x. [DOI] [PubMed] [Google Scholar]
  3. Cooke A., Lydyard P. M., Roitt I. M. Autoimmunity and idiotypes. Lancet. 1984 Sep 29;2(8405):723–725. doi: 10.1016/s0140-6736(84)92628-x. [DOI] [PubMed] [Google Scholar]
  4. Delves P. J., Roitt I. M. Idiotypic determinants on human thyroglobulin autoantibodies derived from the serum of Hashimoto patients and EB virus transformed cell lines. Clin Exp Immunol. 1984 Jul;57(1):33–40. [PMC free article] [PubMed] [Google Scholar]
  5. Diamond B., Scharff M. D. Somatic mutation of the T15 heavy chain gives rise to an antibody with autoantibody specificity. Proc Natl Acad Sci U S A. 1984 Sep;81(18):5841–5844. doi: 10.1073/pnas.81.18.5841. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Isenberg D. A., Colaco C. B., Dudeney C., Todd-Pokropek A., Snaith M. L. The relationship of anti-DNA antibody idiotypes and anti-cardiolipin antibodies to disease activity in systemic lupus erythematosus. Medicine (Baltimore) 1986 Jan;65(1):46–55. doi: 10.1097/00005792-198601000-00003. [DOI] [PubMed] [Google Scholar]
  7. Isenberg D. A., Shoenfeld Y., Madaio M. P., Rauch J., Reichlin M., Stollar B. D., Schwartz R. S. Anti-DNA antibody idiotypes in systemic lupus erythematosus. Lancet. 1984 Aug 25;2(8400):417–422. doi: 10.1016/s0140-6736(84)92904-0. [DOI] [PubMed] [Google Scholar]
  8. Isenberg D. A., Shoenfeld Y., Walport M., Mackworth-Young C., Dudeney C., Todd-Pokropek A., Brill S., Weinberger A., Pinkas J. Detection of cross-reactive anti-DNA antibody idiotypes in the serum of systemic lupus erythematosus patients and of their relatives. Arthritis Rheum. 1985 Sep;28(9):999–1007. doi: 10.1002/art.1780280907. [DOI] [PubMed] [Google Scholar]
  9. Jerne N. K. Towards a network theory of the immune system. Ann Immunol (Paris) 1974 Jan;125C(1-2):373–389. [PubMed] [Google Scholar]
  10. Kennedy R. C., Dreesman G. R. Common idiotypic determinant associated with human antibodies to hepatitis B surface antigen. J Immunol. 1983 Jan;130(1):385–389. [PubMed] [Google Scholar]
  11. Kuettner M. G., Wang A. L., Nisonoff A. Quantitative investigations of idiotypic antibodies. VI. Idiotypic specificity as a potential genetic marker for the variable regions of mouse immunoglobulin polypeptide chains. J Exp Med. 1972 Mar 1;135(3):579–595. doi: 10.1084/jem.135.3.579. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Kunkel H. G., Agnello V., Joslin F. G., Winchester R. J., Capra J. D. Cross-idiotypic specificity among monoclonal IgM proteins with anti- -globulin activity. J Exp Med. 1973 Feb 1;137(2):331–342. doi: 10.1084/jem.137.2.331. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Lee S. K., Singh J., Taylor R. B. Subclasses of T cells with different sensitivities to cytotoxic antibody in the presence of anesthetics. Eur J Immunol. 1975 Apr;5(4):259–262. doi: 10.1002/eji.1830050408. [DOI] [PubMed] [Google Scholar]
  14. Lefvert A. K., James R. W., Alliod C., Fulpius B. W. A monoclonal anti-idiotypic antibody against anti-receptor antibodies from myasthenic sera. Eur J Immunol. 1982 Sep;12(9):790–792. doi: 10.1002/eji.1830120917. [DOI] [PubMed] [Google Scholar]
  15. Naparstek Y., Duggan D., Schattner A., Madaio M. P., Goni F., Frangione B., Stollar B. D., Kabat E. A., Schwartz R. S. Immunochemical similarities between monoclonal antibacterial Waldenstrom's macroglobulins and monoclonal anti-DNA lupus autoantibodies. J Exp Med. 1985 Jun 1;161(6):1525–1538. doi: 10.1084/jem.161.6.1525. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Shoenfeld Y., Ben-Yehuda O., Napartstek Y., Wilner Y., Frolichman R., Schattner A., Lavie G., Joshua H., Pinkhas J., Kennedy R. C. The detection of a common idiotype of anti-DNA antibodies in the sera of patients with monoclonal gammopathies. J Clin Immunol. 1986 May;6(3):194–204. doi: 10.1007/BF00918699. [DOI] [PubMed] [Google Scholar]
  17. Shoenfeld Y., Isenberg D. A., Rauch J., Madaio M. P., Stollar B. D., Schwartz R. S. Idiotypic cross-reactions of monoclonal human lupus autoantibodies. J Exp Med. 1983 Sep 1;158(3):718–730. doi: 10.1084/jem.158.3.718. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Shoenfeld Y., Rauch J., Massicotte H., Datta S. K., André-Schwartz J., Stollar B. D., Schwartz R. S. Polyspecificity of monoclonal lupus autoantibodies produced by human-human hybridomas. N Engl J Med. 1983 Feb 24;308(8):414–420. doi: 10.1056/NEJM198302243080802. [DOI] [PubMed] [Google Scholar]
  19. Shoenfeld Y., Zamir R., Joshua H., Lavie G., Pinkhas J. Human monoclonal anti-DNA antibodies react as lymphocytotoxic antibodies. Eur J Immunol. 1985 Oct;15(10):1024–1028. doi: 10.1002/eji.1830151012. [DOI] [PubMed] [Google Scholar]
  20. Tan E. M., Cohen A. S., Fries J. F., Masi A. T., McShane D. J., Rothfield N. F., Schaller J. G., Talal N., Winchester R. J. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1982 Nov;25(11):1271–1277. doi: 10.1002/art.1780251101. [DOI] [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES