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. 1986 Oct;66(1):132–138.

Mitogenic activity of extracellular cationic products produced by group A streptococci; analysis of the lymphocyte response.

M Suzuki, A Vogt
PMCID: PMC1542664  PMID: 3542316

Abstract

The cationic fraction (isoelectric point greater than 8.5) of supernatant products of group A streptococcal cultures exerted a strong mitogenic effect on human peripheral lymphocytes at concentrations as low as 1 ng/well. Incorporation rates were highest at concentrations of 1-10 micrograms; rabbit peripheral lymphocytes also responded strongly, only a weak response was seen with mouse peripheral lymphocytes and rabbit thymocytes. Purified OKT4 positive (T helper) and OKT8 positive (T suppressor) lymphocyte subpopulations both responded, the former more strongly. Although accessory cells (monocytes) were not absolutely necessary, in their presence higher incorporation of 3H-thymidine was observed. Isolated B cells did not respond.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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