Skip to main content
PMC home page
Proceedings of the Royal Society of Medicine logoLink to Proceedings of the Royal Society of Medicine
. 1977;70(Suppl 3):109–113.

Effect of penicillamine on the kidney.

A M Davison 1, A T Day 1, J R Golding 1, D Thomson 1
PMCID: PMC1543578  PMID: 122655

Abstract

Twenty patients with rheumatoid arthritis developing proteinuria when being treated with penicillamine have been studied. In 5 the proteinuria was mild and resolved rapidly. Eleven of the remaining patients have undergone renal biopsy. One was found to have amyloidosis, and in the other 10 there was evidence of an immune complex type of injury, manifested by a granular immunoglobulin deposition within glomerular capillary walls associated with subepithelial deposits, found on electron microscopy. The proteinuria associated with this was mild (mean 2.6 g per 24 h) and occurred on average some eight months after commencing therapy (range 6 weeks to 60 months).

Full text

PDF
113

Images in this article

110Fig 1
on p.110
111Fig 2
on p.111
112Fig 3
on p.112

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ADAMS D. A., GOLDMAN R., MAXWELL M. H., LATTA H. NEPHROTIC SYNDROME ASSOCIATED WITH PENICILLAMINE THERAPY OF WILSON'S DISEASE. Am J Med. 1964 Feb;36:330–336. doi: 10.1016/0002-9343(64)90096-8. [DOI] [PubMed] [Google Scholar]
  2. Clarkson A. R., Morton J. B., Cash J. D. Urinary fibrin-fibrinogen degradation poducts after renal homotransplantation. Lancet. 1970 Dec 12;2(7685):1220–1223. doi: 10.1016/s0140-6736(70)92181-1. [DOI] [PubMed] [Google Scholar]
  3. DIXON F. J., FELDMAN J. D., VAZQUEZ J. J. Experimental glomerulonephritis. The pathogenesis of a laboratory model resembling the spectrum of human glomerulonephritis. J Exp Med. 1961 May 1;113:899–920. doi: 10.1084/jem.113.5.899. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. GOLDBERG A., SMITH J. A., LOCHHEAD A. C. Treatment of lead-poisoning with oral penicillamine. Br Med J. 1963 May 11;1(5340):1270–1275. doi: 10.1136/bmj.1.5340.1270. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Golding J. R., Wilson J. V., Day A. T. Observations on the treatment of rheumatoid disease with penicillamine. Postgrad Med J. 1970 Oct;46(540):599–605. doi: 10.1136/pgmj.46.540.599. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Hayslett J. P., Bensch K. G., Kashgarian M., Rosenberg L. E. Focal glomerulitis due to penicillamine. Lab Invest. 1968 Oct;19(4):376–381. [PubMed] [Google Scholar]
  7. Jaffe I. A. The effect of penicillamine on the laboratory parameters in rheumatoid arthritis. Arthritis Rheum. 1965 Dec;8(6):1064–1079. doi: 10.1002/art.1780080606. [DOI] [PubMed] [Google Scholar]
  8. Luke R. G., Briggs J. D., Fell G. S., Kennedy A. C. Proteinuria associated with D-penicillamine therapy of cystinuria. J Urol. 1968 Feb;99(2):207–210. doi: 10.1016/S0022-5347(17)62675-2. [DOI] [PubMed] [Google Scholar]
  9. Rosenberg L. E., Hayslett J. P. Nephrotoxic effects of penicillamine in cystinuria. JAMA. 1967 Aug 28;201(9):698–699. [PubMed] [Google Scholar]
  10. Stephens A. D., Watts R. W. The treatment of cystinuria with N-acetyl-D-penicillamine, a comparison with the results of D-penicillamine treatment. Q J Med. 1971 Jul;40(159):355–370. [PubMed] [Google Scholar]
  11. Virella G. Degradation of IgG3 monoclonal proteins during storage and in the presence of a thiol (DL-penicillamine). Experientia. 1971 Jan 15;27(1):94–96. doi: 10.1007/BF02137761. [DOI] [PubMed] [Google Scholar]
  12. WALSHE J. M. Wilson's disease; new oral therapy. Lancet. 1956 Jan 7;270(6906):25–26. doi: 10.1016/s0140-6736(56)91859-1. [DOI] [PubMed] [Google Scholar]

Articles from Proceedings of the Royal Society of Medicine are provided here courtesy of Royal Society of Medicine Press

RESOURCES