Skip to main content
PMC home page
Archives of Disease in Childhood logoLink to Archives of Disease in Childhood
. 1975 Jan;50(1):51–56. doi: 10.1136/adc.50.1.51

Immunodeficiency and infantile bone and joint infection.

K N Kuo, G C Lloyd-Roberts, I M Orme, J F Soothill
PMCID: PMC1544479  PMID: 804866

Abstract

Fifteen patients with infantile bone and joint infections were studied immunologically and clinically, 3 at the time of illness and 12 later. Abnormality of immunoglobulins, or complement, or phagocytes was found in 9 patients; 6 were within normal limits for the tests undertaken. Immunodeficiency is probably responsible for the subdued clinical signs of infection and for delayed diagnosis in some patients. It was also related to the extent of femoral head damage in infective arthritis of the hip and to the incidence of wound infection in late elective surgery.

Full text

PDF
51

Images in this article

53FIG. 1.
on p.53
54FIG. 2.
on p.54
55FIG. 3.
on p.55

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. CHILDS B., NYHAN W. L., BORDEN M., BARD L., COOKE R. E. Idiopathic hyperglycinemia and hyperglycinuria: a new disorder of amino acid metabolism. I. Pediatrics. 1961 Apr;27:522–538. [PubMed] [Google Scholar]
  2. Donovan R., Soothill J. F. Immunological studies in children undergoing tonsillectomy. Clin Exp Immunol. 1973 Jul;14(3):347–357. [PMC free article] [PubMed] [Google Scholar]
  3. EYRE-BROOK A. L. Septic arthritis of the hip and osteomyelitis of the upper end of the femur in infants. J Bone Joint Surg Br. 1960 Feb;42-B:11–20. doi: 10.1302/0301-620X.42B1.11. [DOI] [PubMed] [Google Scholar]
  4. Hobbs J. R., Milner R. D., Watt P. J. Gamma-M deficiency predisposing to meningococcal septicaemia. Br Med J. 1967 Dec 9;4(5579):583–586. doi: 10.1136/bmj.4.5579.583. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Miller M. E., Nilsson U. R. A familial deficiency of the phagocytosis-enhancing activity of serum related to a dysfunction of the fifth component of complement (C5). N Engl J Med. 1970 Feb 12;282(7):354–358. doi: 10.1056/NEJM197002122820702. [DOI] [PubMed] [Google Scholar]
  6. Miller M. E. Phagocytosis in the newborn infant: humoral and cellular factors. J Pediatr. 1969 Feb;74(2):255–259. doi: 10.1016/s0022-3476(69)80073-9. [DOI] [PubMed] [Google Scholar]
  7. Ngu J. L., Soothill J. F. Immunoconglutinin and complement changes in children with acute nephritis. Clin Exp Immunol. 1969 Dec;5(6):557–566. [PMC free article] [PubMed] [Google Scholar]
  8. Quie P. G., White J. G., Holmes B., Good R. A. In vitro bactericidal capacity of human polymorphonuclear leukocytes: diminished activity in chronic granulomatous disease of childhood. J Clin Invest. 1967 Apr;46(4):668–679. doi: 10.1172/JCI105568. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Roberts P. H. Disturbed epiphysial growth at the knee after osteomyelitis in infancy. J Bone Joint Surg Br. 1970 Nov;52(4):692–703. [PubMed] [Google Scholar]
  10. Thompson E. N., Soothill J. F. Chronic granulomatous disease: quantitative clinicopathological relationships. Arch Dis Child. 1970 Feb;45(239):24–32. doi: 10.1136/adc.45.239.24. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Publishing Group

RESOURCES