Abstract
21 new cases of infantile spasms were reported in 1976 from paediatric departments in Denmark. The connection between infantile spasms and the Lennox-Gastaut syndrome is mentioned, because of reports of a significantly higher incidence of HLA-B7 in children with Lennox-Gastaut syndrome. The HLA antigen distribution in 19 of the 21 children was compared with that of 1967 healthy adults. No difference in the HLA antigens was demonstrated between children with infantile spasms and controls, whether in the material as a whole, or in the cryptogenic or symptomatic groups. However HLA typing of children with infantile spasms should continue in the search for a potential genetic marker in this grave disease, particularly in view of the reported high incidence of HLA-B7 in children with the Lennox-Gastaut syndrome.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Beaumanoir A., Martin F., Panagopoulos M., Mundler F. Le syndrome de lennox (etude évolutive à propos de trente cas) Schweiz Arch Neurol Neurochir Psychiatr. 1968;102(1):31–62. [PubMed] [Google Scholar]
- Chevrie J. J., Aicardi J. Childhood epileptic encephalopathy with slow spike-wave. A statistical study of 80 cases. Epilepsia. 1972 Apr;13(2):259–271. doi: 10.1111/j.1528-1157.1972.tb05260.x. [DOI] [PubMed] [Google Scholar]
- GIBBS E. L., FLEMING M. M., GIBBS F. A. Diagnosis and prognosis of hypsarhythmia and infantile spasms. Pediatrics. 1954 Jan;13(1):66–73. [PubMed] [Google Scholar]
- Huttenlocher P. R. Dendritic development in neocortex of children with mental defect and infantile spasms. Neurology. 1974 Mar;24(3):203–210. doi: 10.1212/wnl.24.3.203. [DOI] [PubMed] [Google Scholar]
- Jeavons P. M., Bower B. D., Dimitrakoudi M. Long-term prognosis of 150 cases of "West syndrome". Epilepsia. 1973 Jun;14(2):153–164. doi: 10.1111/j.1528-1157.1973.tb03952.x. [DOI] [PubMed] [Google Scholar]
- Smeraldi E., Scorza Smeraldi R., Cazzullo C. L., Guareschi Cazzullo A., Fabio G., Canger R. Immunogenetics of the Lennox-Gastaut syndrome: frequency of HL-A antigens and haplotypes in patients and first-degree relatives. Epilepsia. 1975 Dec;16(5):699–703. doi: 10.1111/j.1528-1157.1975.tb04754.x. [DOI] [PubMed] [Google Scholar]
- Watanabe K., Iwase K., Hara K. The evolution of EEG features in infantile spasms: a prospective study. Dev Med Child Neurol. 1973 Oct;15(5):584–596. doi: 10.1111/j.1469-8749.1973.tb05169.x. [DOI] [PubMed] [Google Scholar]