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. 1978 Feb;53(2):150–153. doi: 10.1136/adc.53.2.150

Cows' milk protein-sensitive enteropathy. An important factor in prolonging diarrhoea of acute infective enteritis in early infancy.

N Iyngkaran, M J Robinson, E Sumithran, S K Lam, S D Puthucheary, M Yadav
PMCID: PMC1545336  PMID: 646417

Abstract

The possible role of cows' milk protein in prolonging diarrhoea in very young infants with acute infective enteritis was studied in 14 infants, 9 under the age of 2 months and 5 older than 6 months. Bacterial pathogens were isolated from the stools of 4 infants from the younger age group. After appropriate initial treatment the infants were maintained on a cows' milk protein-free formula. 6 weeks later jejunal biopsies were performed before and 24 hours after challenge with a low lactose cows' milk protein formula. The immunoglobulin and complement levels in the serum and duodenal juice were also estimated at these times. Attempts to isolate bacterial and viral pathogens in stools were again made in all patients. The 5 older infants clinically tolerated cows' milk protein and their pre- and postchallenge jejunal biopsies were within normal limits. However, significant histological changes were observed in the postchallenge jejunal biopsies of all 9 infants under 2 months of age. In addition, 5 of these infants developed diarrhoea. This suggests that the jejunal mucosa of very young infants previously fed a cows' milk protein-based formula and who contract infective enteritis suffers damage when rechallenged with cows' milk protein.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Harrison M., Kilby A., Walker-Smith J. A., France N. E., Wood C. B. Cows' milk protein intolerance: a possible association with gastroenteritis, lactose intolerance, and IgA deficiency. Br Med J. 1976 Jun 19;1(6024):1501–1504. doi: 10.1136/bmj.1.6024.1501. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Hyman C. J., Reiter J., Rodnan J., Drash A. L. Parenteral and oral alimentation in the treatment of the nonspecific protracted diarrheal syndrome of infancy. J Pediatr. 1971 Jan;78(1):17–29. doi: 10.1016/s0022-3476(71)80260-3. [DOI] [PubMed] [Google Scholar]
  3. Iyngkaran N., Robinson M. J., Prathap K., Sumithran E., Yadav M. Cows' milk protein-sensitive enteropathy. Combined clinical and histological criteria for diagnosis. Arch Dis Child. 1978 Jan;53(1):20–26. doi: 10.1136/adc.53.1.20. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. KERRY K. R., ANDERSON C. M. A WARD TEST FOR SUGAR IN FAECES. Lancet. 1964 May 2;1(7340):981–981. doi: 10.1016/s0140-6736(64)91777-5. [DOI] [PubMed] [Google Scholar]
  5. Kamath K. R., Murugasu R. A comparative study of four methods for detecting Giardia lamblia in children with diarrheal disease and malabsorption. Gastroenterology. 1974 Jan;66(1):16–21. [PubMed] [Google Scholar]
  6. Lifshitz F., Coello-Ramirez P., Gutierrez-Topete G., Cornado-Cornet M. C. Carbohydrate intolerance in infants with diarrhea. J Pediatr. 1971 Nov;79(5):760–767. doi: 10.1016/s0022-3476(71)80388-8. [DOI] [PubMed] [Google Scholar]
  7. Liu H. Y., Tsao M. U., Moore B., Giday Z. Bovine milk protein-induced intestinal malabsorption of lactose and fat in infants. Gastroenterology. 1968 Jan;54(1):27–34. [PubMed] [Google Scholar]
  8. Shwachman H., Lloyd-Still J. D., Khaw K. T., Antonowicz I. Protracted diarrhea of infancy treated by intravenous alimentation. II. Studies of small intestinal biopsy results. Am J Dis Child. 1973 Mar;125(3):365–368. doi: 10.1001/archpedi.1973.04160030039007. [DOI] [PubMed] [Google Scholar]

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