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. 1979 Jun;54(6):466–468. doi: 10.1136/adc.54.6.466

Cushing's disease presenting with growth failure: clinical remission during cyproheptadine therapy.

D B Grant, S M Atherden
PMCID: PMC1545428  PMID: 475431

Abstract

A 14.7 year-old boy had almost complete suppression of growth as a result of mild pituitary-dependent Cushing's disease. There was complete clinical remission during treatment with cyproheptadine (12 mg/day) and this was maintained when treatment was stopped after 18 months.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Allgrove J., Husband P., Brook C. G. Cushing's disease: failure of treatment with cyproheptadine. Br Med J. 1977 Mar 12;1(6062):686–687. doi: 10.1136/bmj.1.6062.686-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Copinschi G., Nève P., Woltr R., Bastenie P. A. Dwarfism caused by cushing's syndrome. Acta Endocrinol (Copenh) 1969 Mar;60(3):446–450. doi: 10.1530/acta.0.0600446. [DOI] [PubMed] [Google Scholar]
  3. D'Ercole A. J., Morris M. A., Underwood L. E., Van Wyk J. J., Feldman J. M. Treatment of Cushing disease in Childhood with cyproheptadine. J Pediatr. 1977 May;90(5):834–835. doi: 10.1016/s0022-3476(77)81265-1. [DOI] [PubMed] [Google Scholar]
  4. Jennings A. S., Liddle G. W., Orth D. N. Results of treating childhood Cushing's disease with pituitary irradiation. N Engl J Med. 1977 Nov 3;297(18):957–962. doi: 10.1056/NEJM197711032971801. [DOI] [PubMed] [Google Scholar]
  5. Krieger D. T., Amorosa L., Linick F. Cyproheptadine-induced remission of Cushing's disease. N Engl J Med. 1975 Oct 30;293(18):893–896. doi: 10.1056/NEJM197510302931802. [DOI] [PubMed] [Google Scholar]
  6. Lee P. A., Weldon V. V., Migeon C. J. Short stature as the only clinical sign of Cushing's syndrome. J Pediatr. 1975 Jan;86(1):89–91. doi: 10.1016/s0022-3476(75)80710-4. [DOI] [PubMed] [Google Scholar]
  7. Plonk J., Feldman J. Modification of adrenal function by the anti-serotonin agent cyproheptadine. J Clin Endocrinol Metab. 1976 Feb;42(2):291–295. doi: 10.1210/jcem-42-2-291. [DOI] [PubMed] [Google Scholar]
  8. Putnam T. I., Aceto T., Abbassi V., Kenny F. M. Cushing's disease with a spontaneous remission. Pediatrics. 1972 Sep;50(3):477–481. [PubMed] [Google Scholar]
  9. Solomon I. L., Schoen E. J. Juvenile Cushing syndrome manifested primarily by growth failure. Am J Dis Child. 1976 Feb;130(2):200–202. doi: 10.1001/archpedi.1976.02120030090018. [DOI] [PubMed] [Google Scholar]
  10. Streeten D. H., Faas F. H., Elders M. J., Dalakos T. G., Voorhess M. Hypercortisolism in childhood: shortcomings of conventional diagnostic criteria. Pediatrics. 1975 Nov;56(5):797–803. [PubMed] [Google Scholar]
  11. Tyrrell J. B., Brooks R. M., Fitzgerald P. A., Cofoid P. B., Forsham P. H., Wilson C. B. Cushing's disease. Selective trans-sphenoidal resection of pituitary microadenomas. N Engl J Med. 1978 Apr 6;298(14):753–758. doi: 10.1056/NEJM197804062981401. [DOI] [PubMed] [Google Scholar]
  12. Tyrrell J. B., Wiener-Kronish J., Lorenzi M., Brooks R. M., Forsham P. H. Cushing's disease: growth hormone response to hypoglycemia after correction of hypercortisolism. J Clin Endocrinol Metab. 1977 Jan;44(1):218–221. doi: 10.1210/jcem-44-1-218. [DOI] [PubMed] [Google Scholar]

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