Skip to main content
PMC home page
Archives of Disease in Childhood logoLink to Archives of Disease in Childhood
. 1979 Jul;54(7):492–498. doi: 10.1136/adc.54.7.492

Physiological responses of the newborn infant to resuscitation.

A W Boon, A D Milner, I E Hopkin
PMCID: PMC1545470  PMID: 384919

Abstract

Lung ventilation, endotracheal, and intraoesophageal pressures were measured during standard resuscitation of 20 asphyxiated babies born by caesarean section. The most common response to resuscitation was the production of a large positive intraoesphageal pressure. An opening pressure greater than 2.0 kPa was required to expand the lungs of most of these babies. The need for resuscitation was associated with prolonged maternal anaesthesia before delivery.

Full text

PDF
498

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AGOSTONI E. Volume-pressure relationships of the thorax and lung in the newborn. J Appl Physiol. 1959 Nov;14:909–913. doi: 10.1152/jappl.1959.14.6.909. [DOI] [PubMed] [Google Scholar]
  2. AVERY M. E., MEAD J. Surface properties in relation to atelectasis and hyaline membrane disease. AMA J Dis Child. 1959 May;97(5 Pt 1):517–523. doi: 10.1001/archpedi.1959.02070010519001. [DOI] [PubMed] [Google Scholar]
  3. Burger E. J., Jr, Macklem P. Airway closure: demonstration by breathing 100 percent O2 at low lung volumes and by N2 washout. J Appl Physiol. 1968 Aug;25(2):139–148. doi: 10.1152/jappl.1968.25.2.139. [DOI] [PubMed] [Google Scholar]
  4. CRAIG J. M. DISTENSIBILITY CURVES AND EXPANSION PATTERNS OF NEWBORN LUNGS. THE UNIQUE PATTERN OF LUNGS OF INFANTS WITH HYALINE MEMBRANES. Am J Dis Child. 1963 Aug;106:174–184. doi: 10.1001/archpedi.1963.02080050176010. [DOI] [PubMed] [Google Scholar]
  5. CROSS K. W., KLAUS M., TOOLEY W. H., WEISSER K. The response of the new-born baby to inflation of the lungs. J Physiol. 1960 Jun;151:551–565. doi: 10.1113/jphysiol.1960.sp006459. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Coleridge H. M., Coleridge J. C., Luck J. C. Pulmonary afferent fibres of small diameter stimulated by capsaicin and by hyperinflation of the lungs. J Physiol. 1965 Jul;179(2):248–262. doi: 10.1113/jphysiol.1965.sp007660. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Fleming P. J., Bryan A. C., Bryan M. H. Functional immaturity of pulmonary irritant receptors and apnea in newborn preterm infants. Pediatrics. 1978 Apr;61(4):515–518. [PubMed] [Google Scholar]
  8. GRIBETZ I., FRANK N. R., AVERY M. E. Static volume-pressure relations of excised lungs of infants with hyaline membrane disease, newborn and stillborn infants. J Clin Invest. 1959 Dec;38:2168–2175. doi: 10.1172/JCI103996. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. GRUENWOLD P. Normal and abnormal expansion of the lungs of newborn infants obtained at autopsy. III. Opening presure, maximal volume, and stability of expansion. Lab Invest. 1963 May;12:563–576. [PubMed] [Google Scholar]
  10. Hull D. Lung expansion and ventilation during resuscitation of asphyxiated newborn infants. J Pediatr. 1969 Jul;75(1):47–58. doi: 10.1016/s0022-3476(69)80100-9. [DOI] [PubMed] [Google Scholar]
  11. KARLBERG P., KOCH G. Respiratory studies in newborn infants. III. Development of mechanics of breathing during the first week of life. A longitudinal study. Acta Paediatr Suppl. 1962 Jun;135:121–129. doi: 10.1111/j.1651-2227.1962.tb08666.x. [DOI] [PubMed] [Google Scholar]
  12. Milner A. D., Sauders R. A. Pressure and volume changes during the first breath of human neonates. Arch Dis Child. 1977 Dec;52(12):918–924. doi: 10.1136/adc.52.12.918. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Milner A. D., Saunders R. A., Hopkin I. E. Effects of delivery by caesarean section on lung mechanics and lung volume in the human neonate. Arch Dis Child. 1978 Jul;53(7):545–548. doi: 10.1136/adc.53.7.545. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Milner A. D., Saunders R. A., Hopkin I. E. Tidal pressure/volume and flow/volume respiratory loop patterns in human neonates. Clin Sci Mol Med. 1978 Mar;54(3):257–264. doi: 10.1042/cs0540257. [DOI] [PubMed] [Google Scholar]
  15. Robinson R. Resuscitation of the newborn. Br J Hosp Med. 1977 Mar;17(3):260, 262, 265-6 PASSIM. [PubMed] [Google Scholar]
  16. Rosen M., Laurence K. M. Expansion pressures and rupture pressures in the newborn lung. Lancet. 1965 Oct 9;2(7415):721–722. doi: 10.1016/s0140-6736(65)90458-7. [DOI] [PubMed] [Google Scholar]
  17. Widdicombe J. G., Sellick H. Vagal deflation and inflation reflexes mediated by lung irritant receptors. Q J Exp Physiol Cogn Med Sci. 1970 Apr;55(2):153–163. doi: 10.1113/expphysiol.1970.sp002060. [DOI] [PubMed] [Google Scholar]

Articles from Archives of Disease in Childhood are provided here courtesy of BMJ Publishing Group

RESOURCES