Skip to main content
PMC home page
British Medical Journal (Clinical Research Ed.) logoLink to British Medical Journal (Clinical Research Ed.)
. 1983 Oct 1;287(6397):940–943. doi: 10.1136/bmj.287.6397.940

Effect of terbutaline sulphate in chronic "allergic" cough.

R Ellul-Micallef
PMCID: PMC1549195  PMID: 6412896

Abstract

The effects of terbutaline sulphate were studied in 30 patients who presented with chronic cough at an allergy clinic. After a three week baseline period terbutaline and its placebo were given for two periods of three weeks each in a randomised, double blind, crossover manner. Patients kept a daily record of day and night cough scores and peak expiratory flow readings. Twenty one patients responded to terbutaline; placebo produced no significant effect. Both day and night cough scores (p less than 0.001) and peak expiratory flow rates were significantly improved (p less than 0.05) by the end of the first week of treatment with terbutaline. This improvement was achieved with only a fairly small change in airway calibre.

Full text

PDF
941

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderson S. D., Seale J. P., Rozea P., Bandler L., Theobald G., Lindsay D. A. Inhaled and oral salbutamol in exercise-induced asthma. Am Rev Respir Dis. 1976 Sep;114(3):493–500. doi: 10.1164/arrd.1976.114.3.493. [DOI] [PubMed] [Google Scholar]
  2. Antonissen L. A., Mitchell R. W., Kroeger E. A., Kepron W., Tse K. S., Stephens N. L. Mechanical alterations of airway smooth muscle in a canine asthmatic model. J Appl Physiol Respir Environ Exerc Physiol. 1979 Apr;46(4):681–687. doi: 10.1152/jappl.1979.46.4.681. [DOI] [PubMed] [Google Scholar]
  3. Benson M. K. Bronchial hyperreactivity. Br J Dis Chest. 1975 Oct;69(0):227–239. doi: 10.1016/0007-0971(75)90090-x. [DOI] [PubMed] [Google Scholar]
  4. Chai H., Farr R. S., Froehlich L. A., Mathison D. A., McLean J. A., Rosenthal R. R., Sheffer A. L., Spector S. L., Townley R. G. Standardization of bronchial inhalation challenge procedures. J Allergy Clin Immunol. 1975 Oct;56(4):323–327. doi: 10.1016/0091-6749(75)90107-4. [DOI] [PubMed] [Google Scholar]
  5. Cockcroft D. W., Killian D. N., Mellon J. J., Hargreave F. E. Protective effect of drugs on histamine-induced asthma. Thorax. 1977 Aug;32(4):429–437. doi: 10.1136/thx.32.4.429. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Corrao W. M., Braman S. S., Irwin R. S. Chronic cough as the sole presenting manifestation of bronchial asthma. N Engl J Med. 1979 Mar 22;300(12):633–637. doi: 10.1056/NEJM197903223001201. [DOI] [PubMed] [Google Scholar]
  7. Dahlén S. E., Hansson G., Hedqvist P., Björck T., Granström E., Dahlén B. Allergen challenge of lung tissue from asthmatics elicits bronchial contraction that correlates with the release of leukotrienes C4, D4, and E4. Proc Natl Acad Sci U S A. 1983 Mar;80(6):1712–1716. doi: 10.1073/pnas.80.6.1712. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Empey D. W., Laitinen L. A., Jacobs L., Gold W. M., Nadel J. A. Mechanisms of bronchial hyperreactivity in normal subjects after upper respiratory tract infection. Am Rev Respir Dis. 1976 Feb;113(2):131–139. doi: 10.1164/arrd.1976.113.2.131. [DOI] [PubMed] [Google Scholar]
  9. Glauser F. L. Variant asthma. Ann Allergy. 1972 Aug;30(8):457–459. [PubMed] [Google Scholar]
  10. Hannaway P. J., Hopper G. D. Cough variant asthma in children. JAMA. 1982 Jan 8;247(2):206–208. [PubMed] [Google Scholar]
  11. Holtzman M. J., Sheller J. R., Dimeo M., Nadel J. A., Boushey H. A. Effect of ganglionic blockade on bronchial reactivity in atopic subjects. Am Rev Respir Dis. 1980 Jul;122(1):17–25. doi: 10.1164/arrd.1980.122.1.17. [DOI] [PubMed] [Google Scholar]
  12. Irwin R. S., Corrao W. M., Pratter M. R. Chronic persistent cough in the adult: the spectrum and frequency of causes and successful outcome of specific therapy. Am Rev Respir Dis. 1981 Apr;123(4 Pt 1):413–417. doi: 10.1164/arrd.1981.123.4.413. [DOI] [PubMed] [Google Scholar]
  13. Irwin R. S., Rosen M. J., Braman S. S. Cough. A comprehensive review. Arch Intern Med. 1977 Sep;137(9):1186–1191. doi: 10.1001/archinte.137.9.1186. [DOI] [PubMed] [Google Scholar]
  14. McFadden E. R., Jr Exertional dyspnea and cough as preludes to acute attacks of bronchial asthma. N Engl J Med. 1975 Mar 13;292(11):555–559. doi: 10.1056/NEJM197503132921103. [DOI] [PubMed] [Google Scholar]
  15. Ryan G., Latimer K. M., Dolovich J., Hargreave F. E. Bronchial responsiveness to histamine: relationship to diurnal variation of peak flow rate, improvement after bronchodilator, and airway calibre. Thorax. 1982 Jun;37(6):423–429. doi: 10.1136/thx.37.6.423. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Salome C. M., Schoeffel R. E., Woolcock A. J. Effect of aerosol and oral fenoterol on histamine and methacholine challenge in asthmatic subjects. Thorax. 1981 Aug;36(8):580–584. doi: 10.1136/thx.36.8.580. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Sevelius H., Colmore J. P. Antitussive effect of ethyl dibunate in patients with chronic cough. Clin Pharmacol Ther. 1967 May-Jun;8(3):381–384. doi: 10.1002/cpt196783381. [DOI] [PubMed] [Google Scholar]
  18. Simonsson B. G., Jacobs F. M., Nadel J. A. Role of autonomic nervous system and the cough reflex in the increased responsiveness of airways in patients with obstructive airway disease. J Clin Invest. 1967 Nov;46(11):1812–1818. doi: 10.1172/JCI105671. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Tattersfield A. E. Measurement of bronchial reactivity: a question of interpretation. Thorax. 1981 Aug;36(8):561–565. doi: 10.1136/thx.36.8.561. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Widdicombe J. G. Mechanism of cough and its regulation. Eur J Respir Dis Suppl. 1980;110:11–20. [PubMed] [Google Scholar]
  21. Zoumboulakis D., Anagnostakis D., Albanis V., Matsaniotis N. Steroids in treatment of pertussis. A controlled clinical trial. Arch Dis Child. 1973 Jan;48(1):51–54. doi: 10.1136/adc.48.1.51. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from British Medical Journal (Clinical research ed.) are provided here courtesy of BMJ Publishing Group

RESOURCES