Abstract
The oral bioavailability of zinc was studied in nonpregnant adults before and 24 hours after two weeks of oral supplementation with iron and folic acid. Bioavailability was greatly reduced, and the shape of the plasma curves suggested that this was due to impairment of the intestinal absorption of zinc. The findings suggest that the reduced bioavailability of zinc occurs because of interelement competition in the bowel wall. This might induce zinc depletion.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Aggett P. J., Harries J. T. Current status of zinc in health and disease states. Arch Dis Child. 1979 Dec;54(12):909–917. doi: 10.1136/adc.54.12.909. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bremner I., Mills C. F. Absorption, transport and tissue storage of essential trace elements. Philos Trans R Soc Lond B Biol Sci. 1981 Aug 14;294(1071):75–89. doi: 10.1098/rstb.1981.0090. [DOI] [PubMed] [Google Scholar]
- Cherian M. G., Goyer R. A. Methallothioneins and their role in the metabolism and toxicity of metals. Life Sci. 1978 Jul 3;23(1):1–9. doi: 10.1016/0024-3205(78)90317-x. [DOI] [PubMed] [Google Scholar]
- Hambidge K. M., Krebs N. F., Jacobs M. A., Favier A., Guyette L., Ikle D. N. Zinc nutritional status during pregnancy: a longitudinal study. Am J Clin Nutr. 1983 Mar;37(3):429–442. doi: 10.1093/ajcn/37.3.429. [DOI] [PubMed] [Google Scholar]
- Lind T. Nutrient requirements during pregnancy--I. Am J Clin Nutr. 1981 Apr;34(Suppl 4):669–678. doi: 10.1093/ajcn/34.4.669. [DOI] [PubMed] [Google Scholar]
- Meadows N. J., Ruse W., Smith M. F., Day J., Keeling P. W., Scopes J. W., Thompson R. P., Bloxam D. L. Zinc and small babies. Lancet. 1981 Nov 21;2(8256):1135–1137. doi: 10.1016/s0140-6736(81)90587-0. [DOI] [PubMed] [Google Scholar]
- Solomons N. W., Jacob R. A. Studies on the bioavailability of zinc in humans: effects of heme and nonheme iron on the absorption of zinc. Am J Clin Nutr. 1981 Apr;34(4):475–482. doi: 10.1093/ajcn/34.4.475. [DOI] [PubMed] [Google Scholar]