Skip to main content
Gut logoLink to Gut
. 1969 Oct;10(10):812–819. doi: 10.1136/gut.10.10.812

Studies on the intestinal flora 1

Part II Bacterial flora of the small intestine in patients with gastrointestinal disorders

B S Drasar, Margot Shiner
PMCID: PMC1552988  PMID: 4981709

Abstract

The type and distribution of bacteria in the jejunal juice of patients with a variety of gastrointestinal conditions that might affect the small intestinal flora were examined.

Bacterial colonization of the jejunum defined, in this context, as the occurrence of a bile salttolerant flora consisting of both aerobic and anaerobic bacteria qualitatively resembling that of faeces, was observed only in patients with some form of blind loop. Prominent among the bacteria isolated from these colonized juices were non-sporing anaerobic bacteria, most usually Bacteroides, able to hydrolyse bile salts.

No simple correlation between the patient's fat excretion and bacterial colonization of the jejunum could be demonstrated.

Full text

PDF
815

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. DAWSON A. M., ISSELBACHER K. J. Studies on lipid metabolism in the small intestine with observations on the role of bile salts. J Clin Invest. 1960 May;39:730–740. doi: 10.1172/JCI104090. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Drasar B. S. Cultivation of anaerobic intestinal bacteria. J Pathol Bacteriol. 1967 Oct;94(2):417–427. doi: 10.1002/path.1700940223. [DOI] [PubMed] [Google Scholar]
  3. Drasar B. S., Hill M. J., Shiner M. The deconjugation of bile salts by human intestinal bacteria. Lancet. 1966 Jun 4;1(7449):1237–1238. doi: 10.1016/s0140-6736(66)90242-x. [DOI] [PubMed] [Google Scholar]
  4. GOLDSTEIN F., COZZOLINO H. J., WIRTS C. W. DIARRHEA AND STEATORRHEA DUE TO A LARGE SOLITARY DUODENAL DIVERTICULUM. REPORT OF A CASE. Am J Dig Dis. 1963 Nov;8:937–943. doi: 10.1007/BF02232090. [DOI] [PubMed] [Google Scholar]
  5. Hill M. J., Drasar B. S. Degradation of bile salts by human intestinal bacteria. Gut. 1968 Feb;9(1):22–27. doi: 10.1136/gut.9.1.22. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Lee A., Gordon J., Dubos R. Enumeration of the oxygen sensitive bacteria usually present in the intestine of healthy mice. Nature. 1968 Dec 14;220(5172):1137–1139. doi: 10.1038/2201137a0. [DOI] [PubMed] [Google Scholar]
  7. SHINER M. A capsule for obtaining sterile samples of gastrointestinal fluids. Lancet. 1963 Mar 9;1(7280):532–533. doi: 10.1016/s0140-6736(63)91328-x. [DOI] [PubMed] [Google Scholar]
  8. Tabaqchali S., Hatzioannou J., Booth C. C. Bile-salt deconjugation and steatorrhoea in patients with the stagnant-loop syndrome. Lancet. 1968 Jul 6;2(7558):12–16. doi: 10.1016/s0140-6736(68)92888-2. [DOI] [PubMed] [Google Scholar]
  9. WIRTS C. W., TEMPLETON J. Y., 3rd, FINEBERG C., GOLDSTEIN F. THE CORRECTION OF POSTGASTRECTOMY MALABSORPTION FOLLOWING A JEJUNAL INTERPOSITION OPERATION. Gastroenterology. 1965 Aug;49:141–149. [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES