Skip to main content
PMC home page
Gut logoLink to Gut
. 1969 Nov;10(11):913–920. doi: 10.1136/gut.10.11.913

Measurement of duodenal tryptic activity and 75Se-selenomethionine pancreatic scanning compared as tests of pancreatic function

D M McCarthy, Pamela Brown
PMCID: PMC1553064  PMID: 5358582

Abstract

The results of a subjective assessment of pancreatic function, based on the appearance of a 75Se-pancreatic scan, were compared with measurements of the tryptic activity of duodenal aspirates in 16 normal and 38 abnormal subjects. In normals and in abnormals whose scans showed a generalized rather than a localized abnormality there was close agreement between the results of the two sets. In patients with a localized abnormality of the pancreatic head on scanning the tryptic activity of the aspirate was useful in differentiating carcinoma of the pancreas from that of the common bile duct. In general the scan was the more discriminative test though otherwise the places of the two tests in diagnosis are rather similar. The particular situations in which each test is valuable, or in which one or other test can be omitted, are discussed.

Full text

PDF
915

Images in this article

915FIG. 1
on p.915

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Agnew J. E., McCarthy D. M., Melmed RNBOUCHIER I. A. Count rate analysis as an adjunct to the 75Se-selenomethionine pancreas scan. Br J Radiol. 1969 Oct;42(502):762–769. doi: 10.1259/0007-1285-42-502-762. [DOI] [PubMed] [Google Scholar]
  2. Bock O. A., Bank S., Marks I. N., Jackson W. P. Exocrine pancreatic function in diabetes mellitus. S Afr Med J. 1967 Aug 12;41(30):756–758. [PubMed] [Google Scholar]
  3. CHEY W. Y., SHAY H., SHUMAN C. R. EXTERNAL PANCREATIC SECRETION IN DIABETES MELLITUS. Ann Intern Med. 1963 Dec;59:812–821. doi: 10.7326/0003-4819-59-6-812. [DOI] [PubMed] [Google Scholar]
  4. Cook H. B., Lennard-Jones J. E., Sherif S. M., Wiggins H. S. Measurement of tryptic activity in intestinal juice as a diagnostic test of pancreatic disease. Gut. 1967 Aug;8(4):408–414. doi: 10.1136/gut.8.4.408. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. DREILING D. A. Studies in pancreatic function. IV. The use of the secretin test in the diagnosis of tumors in and about the pancreas. Gastroenterology. 1951 Jun;18(2):184–196. [PubMed] [Google Scholar]
  6. Eaton S. B., Fleischli D. J., Pollard J. J., Nebesar R. A., Potsaid M. S. Comparison of current radiologic approaches to the diagnosis of pancreatic disease. N Engl J Med. 1968 Aug 22;279(8):389–396. doi: 10.1056/NEJM196808222790801. [DOI] [PubMed] [Google Scholar]
  7. George P., Young W. B., Walker J. G., Sherlock S. The value of percutaneous cholangiography. Br J Surg. 1965 Oct;52(10):779–783. doi: 10.1002/bjs.1800521020. [DOI] [PubMed] [Google Scholar]
  8. HANSSON E., BLAU M. INCORPORATION OF SE75-SELENOMETHIONINE INTO PANCREATIC JUICE PROTEINS IN VIVO. Biochem Biophys Res Commun. 1963 Sep 10;13:71–74. doi: 10.1016/0006-291x(63)90165-7. [DOI] [PubMed] [Google Scholar]
  9. Hartley R. C., Gambill E. E., Engstrom G. W., Summerskill H. J. Pancreatic exocrine function. Comparison of responses to augmented secretin stimulus, augmented pancreozymin stimulus, and test meal in health and disease. Am J Dig Dis. 1966 Jan;11(1):27–39. doi: 10.1007/BF02237668. [DOI] [PubMed] [Google Scholar]
  10. Herrera N. E., Gonzalez R., Schwartz R. D., Diggs A. M., Belsky J. Se methionine as a diagnostic agent in malignant lymphoma. J Nucl Med. 1965 Nov;6(11):792–804. [PubMed] [Google Scholar]
  11. LUNDH G. Pancreatic exocrine function in neoplastic and inflammatory disease; a simple and reliable new test. Gastroenterology. 1962 Mar;42:275–280. [PubMed] [Google Scholar]
  12. McCarthy D. M., Kreel L., Agnew J. E., Bouchier I. A. Value of hypotonic duodenography as an adjunct to pancreatic scanning. Gut. 1969 Aug;10(8):665–673. doi: 10.1136/gut.10.8.665. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Melmed R. N., Agnew J. E., Bouchier I. A. The normal and abnormal pancreatic scan. Q J Med. 1968 Oct;37(148):607–624. [PubMed] [Google Scholar]
  14. Raia S., Kreel L. Gas-distension, double-contrast duodenography using the Scott-Harden gastroduodenal tube. Gut. 1966 Aug;7(4):420–424. doi: 10.1136/gut.7.4.420. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Rösch J. Roentgenologic diagnosis of pancreatic disease. Am J Roentgenol Radium Ther Nucl Med. 1967 Jul;100(3):664–672. doi: 10.2214/ajr.100.3.664. [DOI] [PubMed] [Google Scholar]
  16. Sodee D. B. Pancreatic scanning. Radiology. 1966 Oct;87(4):641–645. doi: 10.1148/87.4.641. [DOI] [PubMed] [Google Scholar]
  17. VACCA J. B., HENKE W. J., KNIGHT W. A., Jr THE EXOCRINE PANCREAS IN DIABETES MELLITUS. Ann Intern Med. 1964 Aug;61:242–247. doi: 10.7326/0003-4819-61-2-242. [DOI] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES