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. 1970 Oct;11(10):847–850. doi: 10.1136/gut.11.10.847

The role of chronic blood loss in the pathogenesis of postgastrectomy iron-deficiency anaemia

J M Holt, M W L Gear, G T Warner
PMCID: PMC1553154  PMID: 5312499

Abstract

The role of chronic blood loss in the pathogenesis of postgastrectomy iron-deficiency anaemia was assessed by measurements of blood loss over periods of up to three months, using a whole-body counter and 59Fe. Eleven patients were investigated and eight of these were selected because of a history of iron-deficiency anaemia. Six were shown to be losing blood abnormally, five at a rate of over 150 ml per month. None of the three patients without a history of anaemia lost more than 60 ml per month. At gastroscopy contact bleeding from the mucosa of the gastric remnant was observed in four of the six patients losing blood. The results indicate that in some patients chronic blood loss plays an important role in the pathogenesis of postgastrectomy iron-deficiency anaemia.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BAIRD I. M., BLACKBURN E. K., WILSON G. M. The pathogenesis of anaemia after partial gastrectomy. I. Development of anaemia in relation to time after operation, blood loss, and diet. Q J Med. 1959 Jan;28(109):21–34. [PubMed] [Google Scholar]
  2. BAIRD I. M., WILSON G. M. The pathogenesis of anaemia after partial gastrectomy. II. Iron absorption after partial gastrectomy. Q J Med. 1959 Jan;28(109):35–41. [PubMed] [Google Scholar]
  3. Baird I. M., St John D. J., Nasser S. S. Role of occult blood loss in anaemia after partial gastrectomy. Gut. 1970 Jan;11(1):55–61. doi: 10.1136/gut.11.1.55. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Callender S. T., Witts L. J., Warner G. T., Oliver R. The use of a simple whole-body counter for haematological investigations. Br J Haematol. 1966 May;12(3):276–282. doi: 10.1111/j.1365-2141.1966.tb05634.x. [DOI] [PubMed] [Google Scholar]
  5. Holt J. M., Mayet F. G., Warner G. T., Callender S. T., Gunning A. J. Iron absorption and blood loss in patients with hiatus hernia. Br Med J. 1968 Jul 6;3(5609):22–25. doi: 10.1136/bmj.3.5609.22. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Holt J. M., Mayet F. G., Warner G. T., Callender S. T. Measurement of blood loss by means of a whole-body counter. Br Med J. 1967 Oct 14;4(5571):86–88. doi: 10.1136/bmj.4.5571.86. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Kimber C., Patterson J. F., Weintraub L. R. The pathogenesis of iron deficiency anemia following partial gastrectomy. A study of iron balance. JAMA. 1967 Dec 4;202(10):935–938. [PubMed] [Google Scholar]
  8. Stack B. H., Smith T., Jones J. H., Fletcher J. Measurement of blood and iron loss in colitis with a whole-body counter. Gut. 1969 Oct;10(10):769–773. doi: 10.1136/gut.10.10.769. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Turnberg L. A. The absorption of iron after partial gastrectomy. Q J Med. 1966 Jan;35(137):107–118. [PubMed] [Google Scholar]
  10. Warner G. T., Oliver R. A whole-body counter for clinical measurements utilizing the 'shadow shield' technique. Phys Med Biol. 1966 Jan;11(1):83–94. doi: 10.1088/0031-9155/11/1/307. [DOI] [PubMed] [Google Scholar]
  11. Williams D. G., Truelove S. C., Gear M. W., Massarella G. R., Fitzgerald N. W. Gastroscopy with biopsy and cytological sampling under direct vision. Br Med J. 1968 Mar 2;1(5591):535–539. doi: 10.1136/bmj.1.5591.535. [DOI] [PMC free article] [PubMed] [Google Scholar]

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