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. 1995 Sep;101(3):422–427. doi: 10.1111/j.1365-2249.1995.tb03129.x

T cell receptor repertoire in the peripheral blood and intestinal mucosa of coeliac patients.

N Lahat 1, A Ben-Nun 1, L Cohen 1, A Kinarty 1, A Lerner 1
PMCID: PMC1553235  PMID: 7664488

Abstract

The alpha beta and gamma delta T cell receptor (TCR) repertoire in the peripheral blood and intestinal mucosa of six coeliac and six age-matched controls was analysed by reverse transcription and polymerase chain reaction (PCR). No TCR alpha and gamma delta restriction was observed in coeliacs and controls. However, V gamma 3 was expressed only in coeliac peripheral and intestinal T cells. V delta 2 was strongly expressed in coeliacs and scarcely transcribed in control cells. The unique expression of these gamma delta TCR in coeliac patients suggests that V gamma 3 and perhaps V delta 2 TCR-bearing lymphocytes may play a role in the pathogenesis of coeliac disease.

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