Skip to main content
PMC home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1995 Jul;101(1):13–17. doi: 10.1111/j.1365-2249.1995.tb02270.x

Soluble cell adhesion molecules and von Willebrand factor in children with Kawasaki disease.

M C Nash 1, V Shah 1, M J Dillon 1
PMCID: PMC1553297  PMID: 7542571

Abstract

Fifty-nine children with acute Kawasaki disease (KD), a childhood vasculitis, were compared with 35 children with fever due to infection and 48 healthy children. Levels of soluble E-selectin (sE-selectin), soluble intercellular adhesion molecule-1 (sICAM-1), and soluble vascular cell adhesion molecule-1 (sVCAM-1) in the healthy children were double those found in adults. All three soluble cell adhesion molecules and von Willebrand factor (vWF) were higher in the children with KD than in the healthy children, but only sE-selectin, a marker for activated endothelial cells, and sICAM-1 were higher than in the febrile children. The high levels of vWF in KD appear to reflect the prominent acute-phase reaction. This information can help us to understand further the complex interactions between cytokines, circulating inflammatory cells and the vascular endothelium, and may lead to new therapeutic avenues in KD and other inflammatory diseases and vasculitides.

Full text

PDF
15

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ateş E., Bakkaloğlu A., Saatçi U., Söylemezoğlu O. von Willebrand factor antigen compared with other factors in vasculitic syndromes. Arch Dis Child. 1994 Jan;70(1):40–43. doi: 10.1136/adc.70.1.40. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Belch J. J., Zoma A. A., Richards I. M., McLaughlin K., Forbes C. D., Sturrock R. D. Vascular damage and factor-VIII-related antigen in the rheumatic diseases. Rheumatol Int. 1987;7(3):107–111. doi: 10.1007/BF00270462. [DOI] [PubMed] [Google Scholar]
  3. Blann A. D., Naqvi T., Waite M., McCollum C. N. von Willebrand factor and endothelial damage in essential hypertension. J Hum Hypertens. 1993 Apr;7(2):107–111. [PubMed] [Google Scholar]
  4. Blann A. von Willebrand factor and the endothelium in vascular disease. Br J Biomed Sci. 1993 Jun;50(2):125–134. [PubMed] [Google Scholar]
  5. Bowyer S. L., Ragsdale C. G., Sullivan D. B. Factor VIII related antigen and childhood rheumatic diseases. J Rheumatol. 1989 Aug;16(8):1093–1097. [PubMed] [Google Scholar]
  6. Carlos T. M., Harlan J. M. Leukocyte-endothelial adhesion molecules. Blood. 1994 Oct 1;84(7):2068–2101. [PubMed] [Google Scholar]
  7. Diagnostic guidelines for Kawasaki disease. American Heart Association Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease. Am J Dis Child. 1990 Nov;144(11):1218–1219. [PubMed] [Google Scholar]
  8. Fujiwara H., Hamashima Y. Pathology of the heart in Kawasaki disease. Pediatrics. 1978 Jan;61(1):100–107. [PubMed] [Google Scholar]
  9. Furukawa S., Imai K., Matsubara T., Yone K., Yachi A., Okumura K., Yabuta K. Increased levels of circulating intercellular adhesion molecule 1 in Kawasaki disease. Arthritis Rheum. 1992 Jun;35(6):672–677. doi: 10.1002/art.1780350611. [DOI] [PubMed] [Google Scholar]
  10. Gearing A. J., Newman W. Circulating adhesion molecules in disease. Immunol Today. 1993 Oct;14(10):506–512. doi: 10.1016/0167-5699(93)90267-O. [DOI] [PubMed] [Google Scholar]
  11. Hirose S., Hamashima Y. Morphological observations on the vasculitis in the mucocutaneous lymph node syndrome. A skin biopsy study of 27 patients. Eur J Pediatr. 1978 Aug 17;129(1):17–27. doi: 10.1007/BF00441370. [DOI] [PubMed] [Google Scholar]
  12. Irazuzta J. E., Elbl F., Rees A. R. Factor VIII related antigen (von Willebrand's factor) in Kawasaki disease. Clin Pediatr (Phila) 1990 Jun;29(6):347–348. doi: 10.1177/000992289002900613. [DOI] [PubMed] [Google Scholar]
  13. Kavanaugh A. F., Davis L. S., Nichols L. A., Norris S. H., Rothlein R., Scharschmidt L. A., Lipsky P. E. Treatment of refractory rheumatoid arthritis with a monoclonal antibody to intercellular adhesion molecule 1. Arthritis Rheum. 1994 Jul;37(7):992–999. doi: 10.1002/art.1780370703. [DOI] [PubMed] [Google Scholar]
  14. Kawasaki T., Kosaki F., Okawa S., Shigematsu I., Yanagawa H. A new infantile acute febrile mucocutaneous lymph node syndrome (MLNS) prevailing in Japan. Pediatrics. 1974 Sep;54(3):271–276. [PubMed] [Google Scholar]
  15. Kim D. S., Lee K. Y. Serum soluble E-selectin levels in Kawasaki disease. Scand J Rheumatol. 1994;23(5):283–286. doi: 10.3109/03009749409103730. [DOI] [PubMed] [Google Scholar]
  16. Leung D. Y., Cotran R. S., Kurt-Jones E., Burns J. C., Newburger J. W., Pober J. S. Endothelial cell activation and high interleukin-1 secretion in the pathogenesis of acute Kawasaki disease. Lancet. 1989 Dec 2;2(8675):1298–1302. doi: 10.1016/s0140-6736(89)91910-7. [DOI] [PubMed] [Google Scholar]
  17. Leung D. Y. The potential role of cytokine-mediated vascular endothelial activation in the pathogenesis of Kawasaki disease. Acta Paediatr Jpn. 1991 Dec;33(6):739–744. doi: 10.1111/j.1442-200x.1991.tb02602.x. [DOI] [PubMed] [Google Scholar]
  18. Mason J. C., Kapahi P., Haskard D. O. Detection of increased levels of circulating intercellular adhesion molecule 1 in some patients with rheumatoid arthritis but not in patients with systemic lupus erythematosus. Lack of correlation with levels of circulating vascular cell adhesion molecule 1. Arthritis Rheum. 1993 Apr;36(4):519–527. doi: 10.1002/art.1780360412. [DOI] [PubMed] [Google Scholar]
  19. Newburger J. W., Takahashi M., Burns J. C., Beiser A. S., Chung K. J., Duffy C. E., Glode M. P., Mason W. H., Reddy V., Sanders S. P. The treatment of Kawasaki syndrome with intravenous gamma globulin. N Engl J Med. 1986 Aug 7;315(6):341–347. doi: 10.1056/NEJM198608073150601. [DOI] [PubMed] [Google Scholar]
  20. Newman W., Beall L. D., Carson C. W., Hunder G. G., Graben N., Randhawa Z. I., Gopal T. V., Wiener-Kronish J., Matthay M. A. Soluble E-selectin is found in supernatants of activated endothelial cells and is elevated in the serum of patients with septic shock. J Immunol. 1993 Jan 15;150(2):644–654. [PubMed] [Google Scholar]
  21. Pall A. A., Adu D., Drayson M., Taylor C. M., Richards N. T., Michael J. Circulating soluble adhesion molecules in systemic vasculitis. Nephrol Dial Transplant. 1994;9(7):770–774. [PubMed] [Google Scholar]
  22. Pottinger B. E., Read R. C., Paleolog E. M., Higgins P. G., Pearson J. D. von Willebrand factor is an acute phase reactant in man. Thromb Res. 1989 Feb 15;53(4):387–394. doi: 10.1016/0049-3848(89)90317-4. [DOI] [PubMed] [Google Scholar]
  23. Rothlein R., Mainolfi E. A., Czajkowski M., Marlin S. D. A form of circulating ICAM-1 in human serum. J Immunol. 1991 Dec 1;147(11):3788–3793. [PubMed] [Google Scholar]
  24. Shingu M., Hashimoto M., Ezaki I., Nobunaga M. Effect of cytokine-induced soluble ICAM-1 from human synovial cells on synovial cell-lymphocyte adhesion. Clin Exp Immunol. 1994 Oct;98(1):46–51. doi: 10.1111/j.1365-2249.1994.tb06605.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Short P. E., Williams C. E., Picken A. M., Hill F. G. Factor VIII related antigen: an improved enzyme immunoassay. Med Lab Sci. 1982 Oct;39(4):351–355. [PubMed] [Google Scholar]
  26. Springer T. A. Adhesion receptors of the immune system. Nature. 1990 Aug 2;346(6283):425–434. doi: 10.1038/346425a0. [DOI] [PubMed] [Google Scholar]
  27. Stegeman C. A., Tervaert J. W., Huitema M. G., de Jong P. E., Kallenberg C. G. Serum levels of soluble adhesion molecules intercellular adhesion molecule 1, vascular cell adhesion molecule 1, and E-selectin in patients with Wegener's granulomatosis. Relationship to disease activity and relevance during followup. Arthritis Rheum. 1994 Aug;37(8):1228–1235. doi: 10.1002/art.1780370818. [DOI] [PubMed] [Google Scholar]
  28. Thornhill M. H., Haskard D. O. IL-4 regulates endothelial cell activation by IL-1, tumor necrosis factor, or IFN-gamma. J Immunol. 1990 Aug 1;145(3):865–872. [PubMed] [Google Scholar]
  29. Wellicome S. M., Kapahi P., Mason J. C., Lebranchu Y., Yarwood H., Haskard D. O. Detection of a circulating form of vascular cell adhesion molecule-1: raised levels in rheumatoid arthritis and systemic lupus erythematosus. Clin Exp Immunol. 1993 Jun;92(3):412–418. doi: 10.1111/j.1365-2249.1993.tb03413.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Woolf A. D., Wakerley G., Wallington T. B., Scott D. G., Dieppe P. A. Factor VIII related antigen in the assessment of vasculitis. Ann Rheum Dis. 1987 Jun;46(6):441–447. doi: 10.1136/ard.46.6.441. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES