Skip to main content
PMC home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1972 Jun;11(2):255–264.

Autoimmune haemolytic anaemias. V. Studies on the resistance against complement haemolysis of the red cells of patients with chronic cold agglutinin disease

C P Engelfriet, A E G Kr Von Dem Borne, Do Beckers, E Reynierse, J J Van Loghem
PMCID: PMC1553619  PMID: 4114316

Abstract

Experiments are described the results of which sustain the hypothesis that resistance against complement haemolysis, which is a characteristic of the red cells of patients with chronic cold agglutinin disease, is due to the following mechanism: when red cells react with cold auto-agglutinins in vivo, they are either haemolysed immediately, or, due to an unknown factor, escape direct haemolysis. In the latter case β1E and β1A disappear from the cell membrane. To the sites where these proteins have been attached once, no new β1E or β1A molecules can be bound. Full complement activation thus becomes impossible.

Full text

PDF
255

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brown D. L., Lachmann P. J., Dacie J. V. The in vivo behaviour of complement-coated red cells: studies in C6-deficient, C3-depleted and normal rabbits. Clin Exp Immunol. 1970 Sep;7(3):401–421. [PMC free article] [PubMed] [Google Scholar]
  2. DODGE J. T., MITCHELL C., HANAHAN D. J. The preparation and chemical characteristics of hemoglobin-free ghosts of human erythrocytes. Arch Biochem Biophys. 1963 Jan;100:119–130. doi: 10.1016/0003-9861(63)90042-0. [DOI] [PubMed] [Google Scholar]
  3. Engelfriet C. P., Borne AE vd, Giessen M vd, Beckers D., van Loghem J. J. Autoimmune haemolytic anaemias. I. Serological studies with pure anti-immunoglobulin reagents. Clin Exp Immunol. 1968 Sep;3(7):605–614. [PMC free article] [PubMed] [Google Scholar]
  4. Engelfriet C. P., Pondman K. W., Wolters G., Borne AE von dem, Beckers D., Misset-Groenveld G., van Loghem J. J. Autoimmune haemolytic anaemias. 3. Preparation and examination of specific antisera against complement components and products, and their use in serological studies. Clin Exp Immunol. 1970 May;6(5):721–732. [PMC free article] [PubMed] [Google Scholar]
  5. Evans R. S., Turner E., Bingham M. Chronic hemolytic anemia due to cold agglutinins: the mechanism of resistance of red cells to C' hemolysis by cold agglutinins. J Clin Invest. 1967 Sep;46(9):1461–1474. doi: 10.1172/JCI105638. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Evans R. S., Turner E., Bingham M., Woods R. Chronic hemolytic anemia due to cold agglutinins. II. The role of C' in red cell destruction. J Clin Invest. 1968 Apr;47(4):691–701. doi: 10.1172/JCI105764. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Feizi T., Kabat E. A., Vicari G., Anderson B., Marsh W. L. Immunochemical studies on blood groups.XLIX. The I antigen complex: specificity differences among anti-I sera revealed by quantitative precipitin studies; partial structure of the I determinant specific for one anti-I serum. J Immunol. 1971 Jun;106(6):1578–1592. [PubMed] [Google Scholar]
  8. Frank M. M., Dourmashkin R. R., Humphrey J. H. Observations on the mechanism of immune hemolysis: importance of immunoglobulin class and source of complement on the extent of damage. J Immunol. 1970 Jun;104(6):1502–1510. [PubMed] [Google Scholar]
  9. Gerbal A., Homberg J. C., Rochant H., Perron L., Salmon C. Les auto-anticorps d'anémies hémolytiques acquises. II. Nature, spécificité, intérêt clinique et méchanisme de formation. Nouv Rev Fr Hematol. 1968 May-Jun;8(3):351–368. [PubMed] [Google Scholar]
  10. Gigli I., Nelson R. A., Jr Complement dependent immune phagocytosis. I. Requirements for C'1, C'4, C'2, C'3. Exp Cell Res. 1968 Jul;51(1):45–67. doi: 10.1016/0014-4827(68)90158-4. [DOI] [PubMed] [Google Scholar]
  11. HARBOE M., MUELLER-EBERHARD H. J., FUDENBERG H., POLLY M. J., MOLLISON P. L. IDENTIFICATION OF THE COMPONENTS OF COMPLEMENT PARTICIPATING IN THE ANTIGLOBULIN REACTION. Immunology. 1963 Jul;6:412–420. [PMC free article] [PubMed] [Google Scholar]
  12. HUNTER W. M., GREENWOOD F. C. Preparation of iodine-131 labelled human growth hormone of high specific activity. Nature. 1962 May 5;194:495–496. doi: 10.1038/194495a0. [DOI] [PubMed] [Google Scholar]
  13. Muller-Eberhard H. J., Nilsson U. R., Dalmasso A. P., Polley M. J., Calcott M. A. A molecular concept of immune cytolysis. Arch Pathol. 1966 Sep;82(3):205–217. [PubMed] [Google Scholar]
  14. Ruddy S., Austen K. F. C3 inactivator of man. I. Hemolytic measurement by the inactivation of cell-bound C3. J Immunol. 1969 Mar;102(3):533–543. [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES