Skip to main content
PMC home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1972 Sep;12(1):121–132.

Differences in immune elimination in inbred mice: the role of low affinity antibody

J H Alpers, M W Steward, J F Soothill
PMCID: PMC1553642  PMID: 5083460

Abstract

The rate of elimination of soluble protein antigen injected intravenously differs in different inbred strains of mice previously immunized to the antigen. This difference is apparently related to the affinity of the antibody they produce. Animals producing high affinity antibody eliminate antigen more effectively than those producing low affinity antibody. Passive transfer of antibody shows that the difference of antigen elimination is a property of the antibody, rather than the cellular mechanisms involved. The immunopathological significance of these findings is discussed.

Full text

PDF
125

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BENACERRAF B., SEBESTYEN M., COOPER N. S. The clearance of antigen antibody complexes from the blood by the reticuloendothelial system. J Immunol. 1959 Feb;82(2):131–137. [PubMed] [Google Scholar]
  2. Christian C. L. Character of non-precipitating antibodies. Immunology. 1970 Apr;18(4):457–466. [PMC free article] [PubMed] [Google Scholar]
  3. Christian C. L. Immune-complex disease. N Engl J Med. 1969 Apr 17;280(16):878–884. doi: 10.1056/NEJM196904172801610. [DOI] [PubMed] [Google Scholar]
  4. Cochrane C. G., Hawkins D. Studies on circulating immune complexes. 3. Factors governing the ability of circulating complexes to localize in blood vessels. J Exp Med. 1968 Jan 1;127(1):137–154. doi: 10.1084/jem.127.1.137. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. DIXON F. J., FELDMAN J. D., VAZQUEZ J. J. Experimental glomerulonephritis. The pathogenesis of a laboratory model resembling the spectrum of human glomerulonephritis. J Exp Med. 1961 May 1;113:899–920. doi: 10.1084/jem.113.5.899. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. FARR R. S. A quantitative immunochemical measure of the primary interaction between I BSA and antibody. J Infect Dis. 1958 Nov-Dec;103(3):239–262. doi: 10.1093/infdis/103.3.239. [DOI] [PubMed] [Google Scholar]
  7. Lightfoot R. W., Jr, Drusin R. E., Christian C. L. Properties of soluble immune complexes. J Immunol. 1970 Dec;105(6):1493–1500. [PubMed] [Google Scholar]
  8. MAURER P. H., TALMAGE D. W. The effect of the presence of complement in rabbit serum on the quantitative precipitin reaction. II. Effect on antigen and antibody precipitation. J Immunol. 1953 May;70(5):435–440. [PubMed] [Google Scholar]
  9. Mannik M., Arend M. P., Hall A. P., Gilliland B. C. Studies on antigen-antibody complexes. I. Elimination of soluble complexes from rabbit circulation. J Exp Med. 1971 Apr 1;133(4):713–739. doi: 10.1084/jem.133.4.713. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. McFARLANE A. S. Efficient trace-labelling of proteins with iodine. Nature. 1958 Jul 5;182(4627):53–53. doi: 10.1038/182053a0. [DOI] [PubMed] [Google Scholar]
  11. NISONOFF A., PRESSMAN D. Heterogeneity and average combining constants of antibodies from individual rabbits. J Immunol. 1958 Jun;80(6):417–428. [PubMed] [Google Scholar]
  12. Oldstone M. B., Dixon F. J. Pathogenesis of chronic disease associated with persistent lymphocytic choriomeningitis viral infection. I. Relationship of antibody production to disease in neonatally infected mice. J Exp Med. 1969 Mar 1;129(3):483–505. doi: 10.1084/jem.129.3.483. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Paul W., Benacerraf B. Problems encountered in double diffusion analysis in agar of hapten specific immune systems. I. Complement dependent precipitation. J Immunol. 1965 Dec;95(6):1067–1073. [PubMed] [Google Scholar]
  14. Pincus T., Haberkern R., Christian C. L. Experimental chronic glomerulitis. J Exp Med. 1968 Apr 1;127(4):819–832. doi: 10.1084/jem.127.4.819. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Soothill J. F., Steward M. W. The immunopathological significance of the heterogeneity of antibody affinity. Clin Exp Immunol. 1971 Aug;9(2):193–199. [PMC free article] [PubMed] [Google Scholar]
  16. Steward M. W., Petty R. E. The use of ammonium sulphate globulin precipitation for determination of affinity of anti-protein antibodies in mouse serum. Immunology. 1972 May;22(5):747–756. [PMC free article] [PubMed] [Google Scholar]
  17. Unanue E. R., Dixon F. J. Experimental glomerulonephritis: immunological events and pathogenetic mechanisms. Adv Immunol. 1967;6:1–90. doi: 10.1016/s0065-2776(08)60521-0. [DOI] [PubMed] [Google Scholar]
  18. WEIGLE W. O. Elimination of antigen-antibody complexes from sera of rabbits. J Immunol. 1958 Sep;81(3):204–213. [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES