Skip to main content
PMC home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1972 May;11(1):125–135.

Quantitative estimation of antibodies in the immunoglobulin classes of the mouse. I. Effect of adjuvants on the antibody response to human serum albumin and keyhole limpet haemocyanin

G Torrigiani
PMCID: PMC1553676  PMID: 5038769

Abstract

Antibody activity against HSA and KLH was present in all five immunoglobulin classes of BALB/c mice. Bordetella pertussis vaccine was more effective in stimulating antibody production against HSA than against KLH and IgG1 and IgG2b antibody were affected more than the antibody present in the other immunoglobulin classes. The results are discussed in relation to the differing thymic dependence of these two antigens.

Full text

PDF
135

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ASKONAS B. A. A study on globulin formation by plasma-cell neoplasm (5563) transplantable in mice. Biochem J. 1961 Apr;79:33–43. doi: 10.1042/bj0790033. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BENACERRAF B., OVARY Z., BLOCH K. J., FRANKLIN E. C. Properties of guinea pig 7S antibodies. I. Electrophoretic separation of two types of guinea pig 7S antibodies. J Exp Med. 1963 Jun 1;117:937–949. doi: 10.1084/jem.117.6.937. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. CEBRA J. J., GIVOL D., SILMAN H. I., KATCHALSKI E. A two-stage cleavage of rabbit gamma-globulin by a water-insoluble papain preparation followed by cysteine. J Biol Chem. 1961 Jun;236:1720–1725. [PubMed] [Google Scholar]
  4. Coe J. E. 7Sgamma-1 and 7Sgamma-2 antibody response in the mouse. I. Influence of strain, antigen and adjuvant. J Immunol. 1966 Apr;96(4):744–753. [PubMed] [Google Scholar]
  5. FAHEY J. L., WUNDERLICH J., MISHELL R. THE IMMUNOGLOBULINS OF MICE. I. FOUR MAJOR CLASSES OF IMMUNOGLOBULINS: 7S GAMMA-2-, 7S GAMMA-1-, GAMMA-1A (BETA-2A)-, AND 18S GAMMA-1M-GLOBULINS. J Exp Med. 1964 Aug 1;120:223–242. doi: 10.1084/jem.120.2.223. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. FAHEY J. L., WUNDERLICH J., MISHELL R. THE IMMUNOGLOBULINS OF MICE. II. TWO SUBCLASSES OF MOUSE 7S GAMMA-2-GLOBULINS: GAMMA-2A- AND GAMMA-2B-GLOBULINS. J Exp Med. 1964 Aug 1;120:243–251. doi: 10.1084/jem.120.2.243. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. GREENWOOD F. C., HUNTER W. M., GLOVER J. S. THE PREPARATION OF I-131-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY. Biochem J. 1963 Oct;89:114–123. doi: 10.1042/bj0890114. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. HUMPHREY J. H., PARROTT D. M., EAST J. STUDIES ON GLOBULIN AND ANTIBODY PRODUCTION IN MICE THYMECTOMIZED AT BIRTH. Immunology. 1964 Jul;7:419–439. [PMC free article] [PubMed] [Google Scholar]
  9. LEE J. M., OLITSKY P. K. Simple method for enhancing development of acute disseminated encephalomyelitis in mice. Proc Soc Exp Biol Med. 1955 Jun;89(2):263–266. doi: 10.3181/00379727-89-21778. [DOI] [PubMed] [Google Scholar]
  10. McDevitt H. O. Genetic control of the antibody response. 3. Qualitative and quantitative characterization of the antibody response to (T,G)-A--L in CBA and C57 mice. J Immunol. 1968 Mar;100(3):485–492. [PubMed] [Google Scholar]
  11. Mitchison N. A. The immunogenic capacity of antigen taken up by peritoneal exudate cells. Immunology. 1969 Jan;16(1):1–14. [PMC free article] [PubMed] [Google Scholar]
  12. SHAW C. M., ALVORD E. C., Jr, FAHLBERG W. J., KIES M. W. SUBSTITUTES FOR THE MYCOBACTERIA IN FREUND'S ADJUVANTS IN THE PRODUCTION OF EXPERIMENTAL "ALLERGIC" ENCEPHALOMYELITIS IN THE GUINEA PIG. J Immunol. 1964 Jan;92:28–40. [PubMed] [Google Scholar]
  13. Sell S., Park A. B., Nordin A. A. Immunoglobulin classes of antibody-forming cells in mice. I. Localized hemolysis-in-agar plaque-forming cells belonging to five immunoglobulin classes. J Immunol. 1970 Feb;104(2):483–494. [PubMed] [Google Scholar]
  14. Taub R. N., Krantz A. R., Dresser D. W. The effect of localized injection of adjuvant material on the draining lymph node. I. Histology. Immunology. 1970 Feb;18(2):171–186. [PMC free article] [PubMed] [Google Scholar]
  15. Torrigiani G., Roitt I. M., Doniach D. Quantitative distribution of human thyroglobulin autoantibodies in different immunoglobulin classes. Clin Exp Immunol. 1968 Sep;3(7):621–630. [PMC free article] [PubMed] [Google Scholar]
  16. WHITE R. G., COONS A. H., CONNOLLY J. M. Studies on antibody production. IV. The role of a wax fraction of Mycobacterium tuberculosis in adjuvant emulsions on the production of antibody to egg albumin. J Exp Med. 1955 Jul 1;102(1):83–104. doi: 10.1084/jem.102.1.83. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. WHITE R. G., JENKINS G. C., WILKINSON P. C. The production of skin-sensitizing antibody in the guinea-pig. Int Arch Allergy Appl Immunol. 1963;22:156–165. doi: 10.1159/000229362. [DOI] [PubMed] [Google Scholar]
  18. Wortis H. H., Dresser D. W., Anderson H. R. Antibody production studied by means of the localized haemolysis in gel (LHG) assay. 3. Mouse cells producing five different classes of antibody. Immunology. 1969 Jul;17(1):93–110. [PMC free article] [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES