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. 1973 Sep;15(1):9–16.

Immunological studies of Australia antigen carriers with and without liver diseases

J O Nielsen, V Reinicke, O Dietrichson, V Andersen, M Thomsen, E Andersen
PMCID: PMC1553860  PMID: 4587828

Abstract

Examination of the cell-mediated and the humoral immune systems was carried out in two groups of persistent carriers of Australia antigen. Group A included eleven blood donors with an entirely normal liver histology and without previous history of liver disease. Group B included seven patients with an initial acute `viral' hepatitis verified by biopsy. Subsequent biopsies revealed progression to chronic persistent hepatitis in three cases, to chronic aggressive hepatitis in three, and a suspicion of chronicity in one of the patients.

The patients in group B had significantly higher serum concentration of IgM and significantly lower serum concentration of complement C4 than the healthy carriers in group A. No differences were found between the two groups with respect to the presence of autoantibodies or the antibody response to vaccination with keyhole limpet haemocyanin. Delayed-type cutaneous reactions to 2,4-dinitrochlorobenzene, haemocyanin and PPD were equal in the two groups. The PHA-induced lymphocyte transformation was significantly lower in the group of patients with chronic hepatitis as compared to the healthy carriers, but none of the groups showed a statistically significant difference from a control group of eight laboratory technicians. It is concluded that a general immunodeficiency state is not a prerequisite for developing persistent Au-antigenaemia. The slightly impaired T-cell response to PHA found in patients with persistent Au-antigenaemia and chronic liver disease may be related to the liver disease rather than to the Au-antigen carrier state.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Blumberg B. S., Friedlaender J. S., Woodside A., Sutnick A. I., London W. T. Hepatitis and Australia antigen: autosomal recessive inheritance of susceptibility to infection in humans. Proc Natl Acad Sci U S A. 1969 Apr;62(4):1108–1115. doi: 10.1073/pnas.62.4.1108. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Christoffersen P., Dietrichson O., Faber V., Poulsen H. The occurrence and significance of abnormal bile duct epithelium in chronic aggressive hepatitis. A comparative morphological biochemical, immunological, and prognostic study. Acta Pathol Microbiol Scand A. 1972;80(3):294–302. doi: 10.1111/j.1699-0463.1972.tb00283.x. [DOI] [PubMed] [Google Scholar]
  3. De Groote J., Desmet V. J., Gedigk P., Korb G., Popper H., Poulsen H., Scheuer P. J., Schmid M., Thaler H., Uehlinger E. A classification of chronic hepatitis. Lancet. 1968 Sep 14;2(7568):626–628. doi: 10.1016/s0140-6736(68)90710-1. [DOI] [PubMed] [Google Scholar]
  4. Dudley F. J., Fox R. A., Sherlock S. Cellular immunity and hepatitis-associated, Australia antigen liver disease. Lancet. 1972 Apr 1;1(7753):723–726. doi: 10.1016/s0140-6736(72)90234-6. [DOI] [PubMed] [Google Scholar]
  5. Dupont B., Nielsen L. S., Svejgaard A. Relative importance of Four and LA loci in determining mixed-lymphocyte reaction. Lancet. 1971 Dec 18;2(7738):1336–1340. doi: 10.1016/s0140-6736(71)92359-2. [DOI] [PubMed] [Google Scholar]
  6. Elling P., Nielsen J. O., Dietrichson O. Australia antigen in patients with various liver diseases. Acta Pathol Microbiol Scand B Microbiol Immunol. 1970;78(6):657–663. doi: 10.1111/j.1699-0463.1970.tb04354.x. [DOI] [PubMed] [Google Scholar]
  7. Fouts D. W., Byrne E. B., Israel H. L. Hepatitis-associated antigen and sarcoidosis. Lancet. 1970 Dec 12;2(7685):1257–1257. doi: 10.1016/s0140-6736(70)92224-5. [DOI] [PubMed] [Google Scholar]
  8. Giustino V., Dudley F. J., Sherlock S. Thymus-dependent lymphocyte function in patients with hepatitis-associated antigen. Lancet. 1972 Oct 21;2(7782):850–853. doi: 10.1016/s0140-6736(72)92212-x. [DOI] [PubMed] [Google Scholar]
  9. Hosking C. S., Fitzgerald M. G., Simons M. J. Quantified deficiency of lymphocyte response to phytohaemagglutinin in immune deficiency diseases. Clin Exp Immunol. 1971 Oct;9(4):467–476. [PMC free article] [PubMed] [Google Scholar]
  10. Laurell C. B. Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies. Anal Biochem. 1966 Apr;15(1):45–52. doi: 10.1016/0003-2697(66)90246-6. [DOI] [PubMed] [Google Scholar]
  11. Morphological criteria in viral hepatitis. Review by an international group. Lancet. 1971 Feb 13;1(7694):333–337. [PubMed] [Google Scholar]
  12. Nielsen J. O., Dietrichson O., Elling P., Christoffersen P. Incidence and meaning of persistence of Australia antigen in patients with acute viral hepatitis: development of chronic hepatitis. N Engl J Med. 1971 Nov 18;285(21):1157–1160. doi: 10.1056/NEJM197111182852101. [DOI] [PubMed] [Google Scholar]
  13. Nielsen J. O., Nielsen M. H., Elling P. Differential distribution of Australia-antigen-associated particles in patients with liver diseases and normal carriers. N Engl J Med. 1973 Mar 8;288(10):484–487. doi: 10.1056/NEJM197303082881002. [DOI] [PubMed] [Google Scholar]
  14. Nielsen J. O., Nielsen M. H., Reinicke V. Absence of Dane particles in Au-antigen carriers with a histologically normal liver. Lancet. 1972 Oct 28;2(7783):934–934. doi: 10.1016/s0140-6736(72)92585-8. [DOI] [PubMed] [Google Scholar]
  15. Prince A. M., Burke K. Serum hepatitis antigen (SH): rapid detection by high voltage immunoelectroosmophoresis. Science. 1970 Aug 7;169(3945):593–595. doi: 10.1126/science.169.3945.593. [DOI] [PubMed] [Google Scholar]
  16. Reinicke V., Dybkjaer E., Poulsen H., Banke O., Lylloff K., Nordenfelt E. A study of Australia-antigen-positive blood donors and their recipients, with special reference to liver histology. N Engl J Med. 1972 Apr 20;286(16):867–870. doi: 10.1056/NEJM197204202861604. [DOI] [PubMed] [Google Scholar]
  17. Smith M. G., Golding P. L., Eddleston A. L., Mitchell C. G., Kemp A., Williams R. Cell-mediated immune responses in chronic liver diseases. Br Med J. 1972 Feb 26;1(5799):527–530. doi: 10.1136/bmj.1.5799.527. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Sutnick A. I., Raunio V. K., London W. T., Millman I., Blumberg B. S. New immunologic relationships of Australia antigen. Vox Sang. 1970 Sep-Oct;19(3):296–303. [PubMed] [Google Scholar]
  19. Weeke B. Carbamylated human immunoglobulins tested by electrophoresis in agarose and antibody containing agarose. Scand J Clin Lab Invest. 1968;21(4):351–354. doi: 10.3109/00365516809077006. [DOI] [PubMed] [Google Scholar]

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