Skip to main content
PMC home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1973 Sep;15(1):17–25.

Inhibition of leucocyte migration as an index of rejection in renal transplant recipients

D E Richmond, P B Doak, J D K North
PMCID: PMC1553873  PMID: 4587826

Abstract

In a blind study, the peripheral blood leucocytes of fifteen recipients of cadaver kidney homografts have been checked at regular intervals for migration inhibition in the presence of antigen derived from donor spleen. Six of seven episodes of definite acute rejection were preceded or accompanied by migration inhibition, and four of seven probable acute rejection crisis were similarly accompanied by inhibition. No false positive tests were observed. The technique may be a useful adjunct to present methods of diagnosing acute homograft rejection.

Full text

PDF
20

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bloom B. R., Bennett B. Mechanism of a reaction in vitro associated with delayed-type hypersensitivity. Science. 1966 Jul 1;153(3731):80–82. doi: 10.1126/science.153.3731.80. [DOI] [PubMed] [Google Scholar]
  2. DAVID J. R., AL-ASKARI S., LAWRENCE H. S., THOMAS L. DELAYED HYPERSENSITIVITY IN VITRO. I. THE SPECIFICITY OF INHIBITION OF CELL MIGRATION BY ANTIGENS. J Immunol. 1964 Aug;93:264–273. [PubMed] [Google Scholar]
  3. David J. R. Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction. Proc Natl Acad Sci U S A. 1966 Jul;56(1):72–77. doi: 10.1073/pnas.56.1.72. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Doak P. B., Duke A. J., Maclaurin C. H., Montgomerie J. Z., North J. D. Two years' experience with renal transplantation. N Z Med J. 1968 Oct;68(437):221–227. [PubMed] [Google Scholar]
  5. Eidemiller L. R., Bell P. R. Migration inhibition and homograft rejection in rats. Transplantation. 1972 Jan;13(1):5–8. doi: 10.1097/00007890-197201000-00002. [DOI] [PubMed] [Google Scholar]
  6. Ellis R. J., Read S. E., Zabriskie J. B. Leukocyte migration: a cellular index of renal allograft function. Surg Forum. 1971;22:285–286. [PubMed] [Google Scholar]
  7. Falk R. E., Collste L., Möller G. In vitro detection of transplantation immunity: the inhibition of migration of immune spleen cells and peripheral blood leukocytes by specific antigen. J Immunol. 1970 May;104(5):1287–1292. [PubMed] [Google Scholar]
  8. GEORGE M., VAUGHAN J. H. In vitro cell migration as a model for delayed hypersensitivity. Proc Soc Exp Biol Med. 1962 Nov;111:514–521. doi: 10.3181/00379727-111-27841. [DOI] [PubMed] [Google Scholar]
  9. Galanaud P., Crevon M. C., Dormont J., Mathieu P., Weydert A. Leukocyte migration test and renal allograft rejection. Transplantation. 1972 Jan;13(1):48–52. doi: 10.1097/00007890-197201000-00012. [DOI] [PubMed] [Google Scholar]
  10. Kaltreider H. B., Soghor D., Taylor J. B., Decker J. L. Capillary tube migration for detection of human delayed hypersensitivity: difficulties encountered with "buffy coat" cells and tuberculin antigen. J Immunol. 1969 Aug;103(2):179–184. [PubMed] [Google Scholar]
  11. McDonald J. C. Serum antibodies in transplantation. N Y State J Med. 1966 Jun 15;66(12):1631–1635. [PubMed] [Google Scholar]
  12. RUBIN A. L., STENZEL K. H., HIRSCHHORN K., BACH F. HISTOCOMPATIBILITY AND IMMUNOLOGIC COMPETENCE IN RENAL HOMOTRANSPLANTATION. Science. 1964 Feb 21;143(3608):815–816. doi: 10.1126/science.143.3608.815. [DOI] [PubMed] [Google Scholar]
  13. Rocklin R. E., Meyers O. L., David J. R. An in vitro assay for cellular hypersensitivity in man. J Immunol. 1970 Jan;104(1):95–102. [PubMed] [Google Scholar]
  14. Smith M. G., Eddleston A. L., Dominguez J. A., Evans D. B., Bewick M., Williams R. Changes in leucocyte migration after renal transplantation. Br Med J. 1969 Nov 1;4(5678):275–278. doi: 10.1136/bmj.4.5678.275. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Soborg M., Bendixen G. Human lymphocyte migration as a parameter of hypersensitivity. Acta Med Scand. 1967 Feb;181(2):247–256. doi: 10.1111/j.0954-6820.1967.tb07255.x. [DOI] [PubMed] [Google Scholar]
  16. Soborg M. In citro migration of peripheral human leucocytes in cellular hypersensitivity. Acta Med Scand. 1968 Jul-Aug;184(1-2):135–139. [PubMed] [Google Scholar]
  17. Thor D. E., Jureziz R. E., Veach S. R., Miller E., Dray S. Cell migration inhibition factor released by antigen from human peripheral lymphocytes. Nature. 1968 Aug 17;219(5155):755–757. doi: 10.1038/219755a0. [DOI] [PubMed] [Google Scholar]
  18. Weeke E., Weeke B., Bendixen G. Organ-specific, antirenal cellular hypersensitivity after kidney transplantation. Acta Med Scand. 1970 Oct;188(4):307–315. doi: 10.1111/j.0954-6820.1970.tb08043.x. [DOI] [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES