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. 1973 Dec;15(4):483–496.

Cryoglobulinaemia in human renal diseases. A study of seventy-six cases

P Druet, P Letonturier, A Contet, C Mandet
PMCID: PMC1553960  PMID: 4778718

Abstract

The frequency of cryoglobulinaemia was statistically significant in acute proliferative endocapillary glomerulonephritis, in membrano-proliferative glomerulonephritis and in lupus glomerulonephritis. They all have in common glomerular cellular proliferation and glomerular deposits of C3. The cryoglobulins in most of these cases contain IgG and IgM. Except for acute proliferative endocapillary glomerulonephritis, a rather good correlation was observed between the cryoglobulin constituents and the immunoglobulins present in the glomerular tuft. Rheumatoid factor was very rarely found in the serum of these patients.

A cryoglobulin characterized by the presence of the three immunoglobulins was also found in cirrhosis of the liver with or without proven glomerulonephritis.

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Selected References

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  1. Agnello V., Koffler D., Eisenberg J. W., Winchester R. J., Kundel H. G. C1g precipitins in the sera of patients with systemic lupus erythematosus and other hypocomplementemic states: characterization of high and low molecular weight types. J Exp Med. 1971 Sep 1;134(3 Pt 2):228s–241s. [PubMed] [Google Scholar]
  2. Andres G. A., Accinni L., Beiser S. M., Christian C. L., Cinotti G. A., Erlanger B. F., Hsu K. C., Seegal B. C. Localization of fluorescein-labeled antinucleoside antibodies in glomeruli of patients with active systemic lupus erythematosus nephritis. J Clin Invest. 1970 Nov;49(11):2106–2118. doi: 10.1172/JCI106428. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Avrameas S. Coupling of enzymes to proteins with glutaraldehyde. Use of the conjugates for the detection of antigens and antibodies. Immunochemistry. 1969 Jan;6(1):43–52. doi: 10.1016/0019-2791(69)90177-3. [DOI] [PubMed] [Google Scholar]
  4. Avrameas S., Ternynck T. The cross-linking of proteins with glutaraldehyde and its use for the preparation of immunoadsorbents. Immunochemistry. 1969 Jan;6(1):53–66. doi: 10.1016/0019-2791(69)90178-5. [DOI] [PubMed] [Google Scholar]
  5. Balázs V., Fröhlich M. M. Anticomplementary effect of cryoglobulinemic sera and isolated cryoglobulins. Am J Med Sci. 1966 Jan;251(1):51–56. doi: 10.1097/00000441-196601000-00009. [DOI] [PubMed] [Google Scholar]
  6. Bariéty J., Druet P., Loirat P., Lagrue G. Les glomérulonéphrites pariétoprolifératives. (G.N.P.P.) Etude histopathologique en microscopie optique, électronique et en immunohistochimie de 49 cas. Corrélations anatomocliniques. Pathol Biol (Paris) 1971 Mar;19(5):259–283. [PubMed] [Google Scholar]
  7. Bluestone R., Goldberg L. S., Cracchiolo A., 3rd, Barnett E. V. Detection and characterization of DNA in mixed (IgG-IgM) cryoglobulins. Int Arch Allergy Appl Immunol. 1970;39(1):16–26. doi: 10.1159/000230330. [DOI] [PubMed] [Google Scholar]
  8. Bokisch V. A., Bernstein D., Krause R. M. Occurrence of 19S and 7S anti-IgGs during hyperimmunization of rabbits with streptococci. J Exp Med. 1972 Oct 1;136(4):799–815. doi: 10.1084/jem.136.4.799. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Bonomo L., Dammacco F. Immune complex cryoglobulinaemia in lepromatous leprosy: a pathogenetic approach to some clinical features of leprosy. Clin Exp Immunol. 1971 Aug;9(2):175–181. [PMC free article] [PubMed] [Google Scholar]
  10. CHRISTIAN C. L., HATFIELD W. B., CHASE P. H. Systemic lupus erythematosus. Cryoprecipitation of sera. J Clin Invest. 1963 Jun;42:823–829. doi: 10.1172/JCI104774. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. COSTANZI J. J., COLTMAN C. A., Jr, CLARK D. A., TENNENBAUM J. I., CRISCUOLO D. CRYOBLOBULINEMIA ASSOCIATED WITH A MACROGLOBULIN; STUDIES OF A 17.5S CRYOPRECIPITATING FACTOR. Am J Med. 1965 Jul;39:163–172. doi: 10.1016/0002-9343(65)90256-1. [DOI] [PubMed] [Google Scholar]
  12. Cream J. J. Cryoglobulins in vasculitis. Clin Exp Immunol. 1972 Jan;10(1):117–126. [PMC free article] [PubMed] [Google Scholar]
  13. Davie J. M., Osterland C. K., Miller E. J., Krause R. M. Immune cryoglobulins in rabbit streptococcal antiserum. J Immunol. 1968 Apr;100(4):814–820. [PubMed] [Google Scholar]
  14. Dixon F. J. The pathogenesis of glomerulonephritis. Am J Med. 1968 Apr;44(4):493–498. doi: 10.1016/0002-9343(68)90050-8. [DOI] [PubMed] [Google Scholar]
  15. Feizi T., Gitlin N. Immune-complex disease of the kidney associated with chronic hepatitis and cryoglobulinaemia. Lancet. 1969 Oct 25;2(7626):873–876. doi: 10.1016/s0140-6736(69)92329-0. [DOI] [PubMed] [Google Scholar]
  16. GRABAR P., WILLIAMS C. A. Méthode permettant l'étude conjuguée des proprietés électrophorétiques et immunochimiques d'un mélange de protéines; application au sérum sanguin. Biochim Biophys Acta. 1953 Jan;10(1):193–194. doi: 10.1016/0006-3002(53)90233-9. [DOI] [PubMed] [Google Scholar]
  17. GRIFFITHS L. L., GILCHRIST L. Cryoglobulinaemia in alcoholic cirrhosis. Lancet. 1953 May 2;1(6766):882–884. doi: 10.1016/s0140-6736(53)92007-8. [DOI] [PubMed] [Google Scholar]
  18. Golde D., Epstein W. Mixed cryoglobulins and glomerulonephritis. Ann Intern Med. 1968 Dec;69(6):1221–1227. doi: 10.7326/0003-4819-69-6-1221. [DOI] [PubMed] [Google Scholar]
  19. Grupe W. E. IgG-B1C cryoglobulins in acute glomerulonephritis. Pediatrics. 1968 Sep;42(3):474–482. [PubMed] [Google Scholar]
  20. Hanauer L. B., Christian C. L. Studies of cryoproteins in systemic lupus erythematosus. J Clin Invest. 1967 Mar;46(3):400–408. doi: 10.1172/JCI105541. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Hijmans W., Radema H., van Es L., Feltkamp T. E., van Loghem J. J., Schaap O. L. Cryoglobulins in New Zealand Black mice. Clin Exp Immunol. 1969 Feb;4(2):227–239. [PMC free article] [PubMed] [Google Scholar]
  22. Jori G. P., Buonanno G. Chronic hepatitis and cirrhosis of the liver in cryoglobulinaemia. Gut. 1972 Aug;13(8):610–613. doi: 10.1136/gut.13.8.610. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Kantor G. L., Goldberg L. S., Johnson B. L., Jr, Derechin M. M., Barnett E. V. Immunologic abnormalities induced by postperfusion cytomegalovirus infection. Ann Intern Med. 1970 Oct;73(4):553–558. doi: 10.7326/0003-4819-73-4-553. [DOI] [PubMed] [Google Scholar]
  24. Klein F., van Rood J. J., van Furth R., Radema H. IgM-IgG cryoglobulinaemia with IgM paraprotein component. Clin Exp Immunol. 1968 Sep;3(7):703–716. [PMC free article] [PubMed] [Google Scholar]
  25. Klein M., Danon F., Brouet J. C., Signoret Y., Seligmann M. Etude immunochimique de 130 cryoglobulines humaines. Rev Eur Etud Clin Biol. 1972 Dec;17(10):948–957. [PubMed] [Google Scholar]
  26. Koffler D., Schur P. H., Kunkel H. G. Immunological studies concerning the nephritis of systemic lupus erythematosus. J Exp Med. 1967 Oct 1;126(4):607–624. doi: 10.1084/jem.126.4.607. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. LOSPALLUTO J., DORWARD B., MILLER W., Jr, ZIFF M. Cryoglobulinemia based on interaction between a gamma macroglobulin and 7S gamma globulin. Am J Med. 1962 Jan;32:142–147. doi: 10.1016/0002-9343(62)90191-2. [DOI] [PubMed] [Google Scholar]
  28. Lagrue G., Bariéty J., Halpern B., Milliez P. Le complément dans les néphropathies humaines. Pathol Biol. 1967 Apr;15(7):378–383. [PubMed] [Google Scholar]
  29. Mackenzie M. R., Goldberg L. S., Barnett E. V., Fudenberg H. H. Serological heterogeneity of the IgM components of mixed (monoclonal IgM-polyclonal IgG) cryoglobulins. Clin Exp Immunol. 1968 Nov;3(9):931–941. [PMC free article] [PubMed] [Google Scholar]
  30. Mancini G., Carbonara A. O., Heremans J. F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965 Sep;2(3):235–254. doi: 10.1016/0019-2791(65)90004-2. [DOI] [PubMed] [Google Scholar]
  31. Marcus R. L., Townes A. S. The occurrence of cryoproteins in synovial fluid; the association of a complement-fixing activity in rheumatoid synovial fluid with cold-precipitable protein. J Clin Invest. 1971 Feb;50(2):282–293. doi: 10.1172/JCI106493. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Mathison D. A., Condemi J. J., Leddy J. P., Callerame M. L., Panner B. J., Vaughan J. H. Purpura, arthralgia, and IgM-IgM cryoglobulinemia with rheumatoid factor acrivity. Response to cyclophosphamide and splenectomy. Ann Intern Med. 1971 Mar;74(3):383–390. doi: 10.7326/0003-4819-74-3-383. [DOI] [PubMed] [Google Scholar]
  33. McIntosh R. M., Kaufman D. B., Kulvinskas C., Grossman B. J. Cryoglobulins. I. Studies on the nature, incidence, and clinical significance of serum cryoproteins in glomerulonephritis. J Lab Clin Med. 1970 Apr;75(4):566–577. [PubMed] [Google Scholar]
  34. McIntosh R. M., Kulvinskas C., Kaufman D. B. Cryoglobulins. II. The biological and chemical properties of cryoproteins in acute post-streptococcal glomerulonephritis. Int Arch Allergy Appl Immunol. 1971;41(5):700–715. doi: 10.1159/000230562. [DOI] [PubMed] [Google Scholar]
  35. Meltzer M., Franklin E. C. Cryoglobulinemia--a study of twenty-nine patients. I. IgG and IgM cryoglobulins and factors affecting cryoprecipitability. Am J Med. 1966 Jun;40(6):828–836. doi: 10.1016/0002-9343(66)90199-9. [DOI] [PubMed] [Google Scholar]
  36. Meltzer M., Franklin E. C., Elias K., McCluskey R. T., Cooper N. Cryoglobulinemia--a clinical and laboratory study. II. Cryoglobulins with rheumatoid factor activity. Am J Med. 1966 Jun;40(6):837–856. doi: 10.1016/0002-9343(66)90200-2. [DOI] [PubMed] [Google Scholar]
  37. Mustakallio K. K., Lassus A., Putkonen T., Wager O. Cryoglobulins and rheumatoid factor in systemic lupus erythematosus. Acta Derm Venereol. 1967;47(4):241–248. [PubMed] [Google Scholar]
  38. PEETOOM F., LOGHEM-LANGEREIS E. IGM-IGG (BETA-2M-7S-GAMMA) CRYOGLOBULINAEMIA AN AUTO-IMMUNE PHENOMEMON. Vox Sang. 1965 May-Jun;10:281–292. doi: 10.1111/j.1423-0410.1965.tb01391.x. [DOI] [PubMed] [Google Scholar]
  39. PORTER R. R. The hydrolysis of rabbit y-globulin and antibodies with crystalline papain. Biochem J. 1959 Sep;73:119–126. doi: 10.1042/bj0730119. [DOI] [PMC free article] [PubMed] [Google Scholar]
  40. Stastny P., Ziff M. Cold-insoluble complexes and complement levels in systemic lupus erythematosus. N Engl J Med. 1969 Jun 19;280(25):1376–1381. doi: 10.1056/NEJM196906192802503. [DOI] [PubMed] [Google Scholar]
  41. Treser G., Semar M., Ty A., Agel I., Franklin M. A., Lange K. Partial characterization of antigenic streptococcal plasma membrane components in acute glomerulonephritis. J Clin Invest. 1970 Apr;49(4):762–768. doi: 10.1172/JCI106289. [DOI] [PMC free article] [PubMed] [Google Scholar]
  42. Wager O., Mustakallio K. K., Räsänen J. A. Mixed IgA-IgG cryoglobulinemia. Immunological studies and case reports of three patients. Am J Med. 1968 Feb;44(2):179–187. doi: 10.1016/0002-9343(68)90149-6. [DOI] [PubMed] [Google Scholar]
  43. Wager O., Räsänen J. A., Hagman A., Klemola E. Mixed cryoimmunoglobulinaemia in infectious mononucleois and Cytomegalovirus mononucleosis. Int Arch Allergy Appl Immunol. 1968;34(4):345–361. doi: 10.1159/000230129. [DOI] [PubMed] [Google Scholar]
  44. Whitsed H. M., Penny R. IgA-IgG cryoglobulinaemia with vasculitis. Clin Exp Immunol. 1971 Aug;9(2):183–191. [PMC free article] [PubMed] [Google Scholar]
  45. Zabriskie J. B. The role of streptococci in human glomerulonephritis. J Exp Med. 1971 Sep 1;134(3 Pt 2):180s–192s. [PubMed] [Google Scholar]

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