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. 1974 May;17(1):121–128.

Phagocyte function in protein-calorie malnutrition

S D Douglas, K Schopfer
PMCID: PMC1554055  PMID: 4143112

Abstract

Sixteen children with the kwashiorkor type of protein-calorie malnutrition (PCM) have been investigated in an attempt to assess the functional activity of their peripheral blood phagocytes. Hexose-monophosphate shunt (HMS) activity in the resting and phagocytizing state and bactericidal capacity with Escherischia coli and Staphylococcus aureus were measured. The findings indicate HMS stimulation in the normal range as determined by 14CO2 production during phagocytosis. The bactericidal capacity of phagocytes from kwashiorkor patients was normal in the early phase (first 30 min) and significantly reduced during the later phase (after 60 min) of the assay as compared with cells from healthy children.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. COHEN S., HANSEN J. D. Metabolism of albumin and gamma-globulin in kwashiorkor. Clin Sci. 1962 Oct;23:351–359. [PubMed] [Google Scholar]
  2. Davis W. C., Huber H., Douglas S. D., Fudenberg H. H. A defect in circulating mononuclear phagocytes in chronicgranulomatous disease of childhood. J Immunol. 1968 Nov;101(5):1093–1095. [PubMed] [Google Scholar]
  3. Douglas S. D. Analytic review: disorders of phagocyte function. Blood. 1970 Jun;35(6):851–866. [PubMed] [Google Scholar]
  4. Douglas S. D., Davis W. C., Fudenberg H. H. Granulocytopathies: pleomorphism of neutrophil dysfunction. Am J Med. 1969 Jun;46(6):901–909. doi: 10.1016/0002-9343(69)90091-6. [DOI] [PubMed] [Google Scholar]
  5. Douglas S. D., Schmidt M. E., Siltzbach L. E. Monocyte receptor activity in normal individuals and patients with sarcoidosis. Immunol Commun. 1972;1(1):25–38. doi: 10.3109/08820137209022890. [DOI] [PubMed] [Google Scholar]
  6. Geefhuysen J., Rosen E. U., Katz J., Ipp T., Metz J. Impaired cellular immunity in kwashiorkor with improvement after therapy. Br Med J. 1971 Nov 27;4(5786):527–529. doi: 10.1136/bmj.4.5786.527. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Karnovsky M. L. The metabolism of leukocytes. Semin Hematol. 1968 Apr;5(2):156–165. [PubMed] [Google Scholar]
  8. Keusch G. T., Douglas S. D. Radiometric screening test for chronic granulomatous disease. J Nucl Med. 1973 Aug;14(8):591–594. [PubMed] [Google Scholar]
  9. Quie P. G., White J. G., Holmes B., Good R. A. In vitro bactericidal capacity of human polymorphonuclear leukocytes: diminished activity in chronic granulomatous disease of childhood. J Clin Invest. 1967 Apr;46(4):668–679. doi: 10.1172/JCI105568. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. REDDY V., SRIKANTIA S. G. ANTIBODY RESPONSE IN KWASHIORKOR. Indian J Med Res. 1964 Nov;52:1154–1158. [PubMed] [Google Scholar]
  11. Root R. K., Rosenthal A. S., Balestra D. J. Abnormal bactericidal, metabolic, and lysosomal functions of Chediak-Higashi Syndrome leukocytes. J Clin Invest. 1972 Mar;51(3):649–665. doi: 10.1172/JCI106854. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Sellmeyer E., Bhettay E., Truswell A. S., Meyers O. L., Hansen J. D. Lymphocyte transformation in malnourished children. Arch Dis Child. 1972 Jun;47(253):429–435. doi: 10.1136/adc.47.253.429. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Selvaraj R. J., Bhat K. S. [Metabolic and bactericidal activities of leukocytes in protein-calorie malnutrition]. Am J Clin Nutr. 1972 Feb;25(2):166–174. doi: 10.1093/ajcn/25.2.166. [DOI] [PubMed] [Google Scholar]
  14. Sirisinha S., Edelman R., Suskind R., Charupatana C., Olson R. E. Complement and C3-proactivator levels in children with protein-calorie malnutrition and effect of dietary treatment. Lancet. 1973 May 12;1(7811):1016–1020. doi: 10.1016/s0140-6736(73)90663-6. [DOI] [PubMed] [Google Scholar]
  15. Smythe P. M., Brereton-Stiles G. G., Grace H. J., Mafoyane A., Schonland M., Coovadia H. M., Loening W. E., Parent M. A., Vos G. H. Thymolymphatic deficiency and depression of cell-mediated immunity in protein-calorie malnutrition. Lancet. 1971 Oct 30;2(7731):939–943. doi: 10.1016/s0140-6736(71)90267-4. [DOI] [PubMed] [Google Scholar]
  16. Watson C. E., Freesemann C. Immunoglobulins in protein-calorie malnutrition. Arch Dis Child. 1970 Apr;45(240):282–284. doi: 10.1136/adc.45.240.282. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Yoshida T., Metcoff J., Frenk S., De la Pena C. Intermediary metabolites and adenine nucleotides in leucocytes of children with protein-calorie malnutrition. Nature. 1967 Apr 29;214(5087):525–526. doi: 10.1038/214525a0. [DOI] [PubMed] [Google Scholar]

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