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. 1992 Jan;87(1):20–23. doi: 10.1111/j.1365-2249.1992.tb06407.x

HLA-associated susceptibility to HIV-1 infection.

G Fabio 1, R Scorza 1, A Lazzarin 1, M Marchini 1, M Zarantonello 1, A D'Arminio 1, P Marchisio 1, A Plebani 1, R Luzzati 1, P Costigliola 1
PMCID: PMC1554216  PMID: 1733633

Abstract

We studied HLA antigen distribution of 50 heterosexual partners of HIV+ drug abusers with more than 1 year of sexual exposure to HIV, 36 children born to seropositive mothers and 61 haemophiliac patients exposed to presumably infectious clotting factor concentrates. B52 and B44 antigens were associated with HIV resistance while B51 was associated with HIV susceptibility. Forty-nine HIV+ drug abusers, spouses of heterosexual partners studied and 25 HIV+ mothers of the children were also typed. DR11 phenotype was associated with infectiousness of HIV+ subjects. Our data suggest that the HLA region controls susceptibility to infection with HIV and infectiousness of HIV+ subjects in different risk groups.

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Selected References

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  1. Bjorkman P. J., Saper M. A., Samraoui B., Bennett W. S., Strominger J. L., Wiley D. C. Structure of the human class I histocompatibility antigen, HLA-A2. Nature. 1987 Oct 8;329(6139):506–512. doi: 10.1038/329506a0. [DOI] [PubMed] [Google Scholar]
  2. Bodmer H. C., Gotch F. M., McMichael A. J. Class I cross-restricted T cells reveal low responder allele due to processing of viral antigen. Nature. 1989 Feb 16;337(6208):653–655. doi: 10.1038/337653a0. [DOI] [PubMed] [Google Scholar]
  3. Enlow R. W., Nunez Roldan A., LoGalbo P., Mildvan D., Mathur U., Winchester R. J. Increased frequency of HLA-DR5 in lymphadenopathy stage of AIDS. Lancet. 1983 Jul 2;2(8340):51–52. doi: 10.1016/s0140-6736(83)90039-9. [DOI] [PubMed] [Google Scholar]
  4. Fabio G., Smeraldi R. S., Gringeri A., Marchini M., Bonara P., Mannucci P. M. Susceptibility to HIV infection and AIDS in Italian haemophiliacs is HLA associated. Br J Haematol. 1990 Aug;75(4):531–536. doi: 10.1111/j.1365-2141.1990.tb07794.x. [DOI] [PubMed] [Google Scholar]
  5. Jeannet M., Sztajzel R., Carpentier N., Hirschel B., Tiercy J. M. HLA antigens are risk factors for development of AIDS. J Acquir Immune Defic Syndr. 1989;2(1):28–32. [PubMed] [Google Scholar]
  6. Kaslow R. A., Duquesnoy R., VanRaden M., Kingsley L., Marrari M., Friedman H., Su S., Saah A. J., Detels R., Phair J. A1, Cw7, B8, DR3 HLA antigen combination associated with rapid decline of T-helper lymphocytes in HIV-1 infection. A report from the Multicenter AIDS Cohort Study. Lancet. 1990 Apr 21;335(8695):927–930. doi: 10.1016/0140-6736(90)90995-h. [DOI] [PubMed] [Google Scholar]
  7. Kornbluth R. S., Oh P. S., Munis J. R., Cleveland P. H., Richman D. D. The role of interferons in the control of HIV replication in macrophages. Clin Immunol Immunopathol. 1990 Feb;54(2):200–219. doi: 10.1016/0090-1229(90)90082-2. [DOI] [PubMed] [Google Scholar]
  8. McMichael A. J., Gotch F. M., Santos-Aguado J., Strominger J. L. Effect of mutations and variations of HLA-A2 on recognition of a virus peptide epitope by cytotoxic T lymphocytes. Proc Natl Acad Sci U S A. 1988 Dec;85(23):9194–9198. doi: 10.1073/pnas.85.23.9194. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Milich D. R., Leroux-Roels G. G., Louie R. E., Chisari F. V. Genetic regulation of the immune response to hepatitis B surface antigen (HBsAg). IV. Distinct H-2-linked Ir genes control antibody responses to different HBsAg determinants on the same molecule and map to the I-A and I-C subregions. J Exp Med. 1984 Jan 1;159(1):41–56. doi: 10.1084/jem.159.1.41. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Mittal K. K., Mickey M. R., Singal D. P., Terasaki P. I. Serotyping for homotransplantation. 18. Refinement of microdroplet lymphocyte cytotoxicity test. Transplantation. 1968 Nov;6(8):913–927. doi: 10.1097/00007890-196811000-00006. [DOI] [PubMed] [Google Scholar]
  11. Peterman T. A., Stoneburner R. L., Allen J. R., Jaffe H. W., Curran J. W. Risk of human immunodeficiency virus transmission from heterosexual adults with transfusion-associated infections. JAMA. 1988 Jan 1;259(1):55–58. [PubMed] [Google Scholar]
  12. Prince H. E., Schroff R. W., Ayoub G., Han S., Gottlieb M. S., Fahey J. L. HLA studies in acquired immune deficiency syndrome patients with Kaposi's sarcoma. J Clin Immunol. 1984 May;4(3):242–245. doi: 10.1007/BF00914972. [DOI] [PubMed] [Google Scholar]
  13. Raffoux C., David V., Couderc L. D., Rabian C., Clauvel J. P., Seligmann M., Colombani J. HLA-A, B and DR antigen frequencies in patients with AIDS-related persistent generalized lymphadenopathy (PGL) and thrombocytopenia. Tissue Antigens. 1987 Jan;29(1):60–62. doi: 10.1111/j.1399-0039.1987.tb01550.x. [DOI] [PubMed] [Google Scholar]
  14. Scorza Smeraldi R., Fabio G., Lazzarin A., Eisera N. B., Moroni M., Zanussi C. HLA-associated susceptibility to acquired immunodeficiency syndrome in Italian patients with human-immunodeficiency-virus infection. Lancet. 1986 Nov 22;2(8517):1187–1189. doi: 10.1016/s0140-6736(86)92197-5. [DOI] [PubMed] [Google Scholar]
  15. Scorza Smeraldi R., Fabio G., Lazzarin A., Eisera N., Uberti Foppa C., Moroni M., Zanussi C. HLA-associated susceptibility to AIDS: HLA B35 is a major risk factor for Italian HIV-infected intravenous drug addicts. Hum Immunol. 1988 Jun;22(2):73–79. doi: 10.1016/0198-8859(88)90038-9. [DOI] [PubMed] [Google Scholar]
  16. Steel C. M., Ludlam C. A., Beatson D., Peutherer J. F., Cuthbert R. J., Simmonds P., Morrison H., Jones M. HLA haplotype A1 B8 DR3 as a risk factor for HIV-related disease. Lancet. 1988 May 28;1(8596):1185–1188. doi: 10.1016/s0140-6736(88)92009-0. [DOI] [PubMed] [Google Scholar]
  17. Svejgaard A., Jersild C., Nielsen L. S., Bodmer W. F. HL-A antigens and disease. Statistical and genetical considerations. Tissue Antigens. 1974;4(2):95–105. doi: 10.1111/j.1399-0039.1974.tb00230.x. [DOI] [PubMed] [Google Scholar]
  18. Svejgaard A., Platz P., Ryder L. P. HLA and disease 1982--a survey. Immunol Rev. 1983;70:193–218. doi: 10.1111/j.1600-065x.1983.tb00715.x. [DOI] [PubMed] [Google Scholar]
  19. Weller I. V., Carne C. A., Sattentau Q., Smith A., Tedder R. S., Clapham P., Dalgleish A., Weber J., Adler M. W. Human immunodeficiency virus (HIV) infection in the regular sexual partners of homosexual men with AIDS and persistent generalised lymphadenopathy. J Med Virol. 1987 May;22(1):91–98. doi: 10.1002/jmv.1890220111. [DOI] [PubMed] [Google Scholar]

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