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. 1992 Jun;88(3):448–454. doi: 10.1111/j.1365-2249.1992.tb06470.x

Interferon-alpha and dexamethasone inhibit adhesion of T cells to endothelial cells and synovial cells

K Eguchi, A Kawakami, M Nakashima, H Ida, S Sakito, N Matsuoka, K Terada, M Sakai, Y Kawabe, T Fukuda, T Ishimaru, K Kurouji, N Fujita, T Aoyagi, K Maeda, S Nagataki
PMCID: PMC1554515  PMID: 1606729

Abstract

We investigated whether interferon-gamma (IFN-γ), interferon-alpha (IFN-α) and glucocorticoids affected the adhesion of T cells to human umbilical endothelial cells or human synovial cells. About 30% of peripheral blood T cells could bind to unstimulated endothelial cells, but only a few T cells could bind to unstimulated synovial cells. When both endothelial cells and synovial cells were cultured with recombinant IFN-γ (rIFN-γ), the percentage of T cell binding to both types of cells increased in a dose-dependent manner. rIFN-α and dexamethasone blocked the T cell binding to unstimulated endothelial cells. Furthermore, rIFN-α and dexamethasone suppressed T cell binding to both endothelial cells and synovial cells stimulated by IFN-γ, and also inhibited intercellular adhesion molecule-1 (ICAM-1) expression on both endothelial cells and synovial cells stimulated by IFN-γ. These results suggest that IFN-α and glucocorticoids may inhibit T cell binding to endothelial cells or synovial cells by modulating adhesion molecule expression on these cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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