Skip to main content
PMC home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1993 Jan;91(1):25–29. doi: 10.1111/j.1365-2249.1993.tb03348.x

Immunoglobulin G subclass responses to mycobacterial lipoarabinomannan in HIV-infected and non-infected patients with tuberculosis.

C T Da Costa 1, S Khanolkar-Young 1, A M Elliott 1, K M Wasunna 1, K P McAdam 1
PMCID: PMC1554641  PMID: 8419082

Abstract

Immunoglobulin G subclass responses to lipoarabinomannan (LAM) of Mycobacterium tuberculosis were determined by ELISA in both HIV-1 antibody positive (n = 31) and negative (n = 43) patients with tuberculosis (TB). Responses were also studied in a group of healthy controls (n = 16) and HIV-1 antibody positive (n = 60) individuals without TB. IgG2 antibodies were the predominant subclass, being present in 25 of 43 non-HIV-infected TB patients (58%) and in 11 of 31 HIV-infected TB patients (35%). However, HIV+ TB patients also showed IgG4 (n = 16; 52%), and IgG1 (n = 4, 13%) responses to LAM, whereas these subclasses were absent in sera from HIV-TB patients. Individuals in both non-tuberculous control groups showed no antibody responses to LAM. The influence of HIV infection on B cell responses to LAM, and possible mechanisms for antibody-mediated regulation of immunity to TB, are explored.

Full text

PDF
27

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aalberse R. C., van der Gaag R., van Leeuwen J. Serologic aspects of IgG4 antibodies. I. Prolonged immunization results in an IgG4-restricted response. J Immunol. 1983 Feb;130(2):722–726. [PubMed] [Google Scholar]
  2. Aucouturier P., Couderc L. J., Gouet D., Danon F., Gombert J., Matheron S., Saimot A. G., Clauvel J. P., Preud'homme J. L. Serum immunoglobulin G subclass dysbalances in the lymphadenopathy syndrome and acquired immune deficiency syndrome. Clin Exp Immunol. 1986 Jan;63(1):234–240. [PMC free article] [PubMed] [Google Scholar]
  3. Aucouturier P., Danon F., Daveau M., Guillou B., Sabbah A., Besson J., Preud'homme J. L. Measurement of serum IgG4 levels by a competitive immunoenzymatic assay with monoclonal antibodies. J Immunol Methods. 1984 Nov 16;74(1):151–162. doi: 10.1016/0022-1759(84)90376-4. [DOI] [PubMed] [Google Scholar]
  4. Ballet J. J., Sulcebe G., Couderc L. J., Danon F., Rabian C., Lathrop M., Clauvel J. P., Seligmann M. Impaired anti-pneumococcal antibody response in patients with AIDS-related persistent generalized lymphadenopathy. Clin Exp Immunol. 1987 Jun;68(3):479–487. [PMC free article] [PubMed] [Google Scholar]
  5. Burton D. R., Gregory L., Jefferis R. Aspects of the molecular structure of IgG subclasses. Monogr Allergy. 1986;19:7–35. [PubMed] [Google Scholar]
  6. Chaisson R. E., Schecter G. F., Theuer C. P., Rutherford G. W., Echenberg D. F., Hopewell P. C. Tuberculosis in patients with the acquired immunodeficiency syndrome. Clinical features, response to therapy, and survival. Am Rev Respir Dis. 1987 Sep;136(3):570–574. doi: 10.1164/ajrccm/136.3.570. [DOI] [PubMed] [Google Scholar]
  7. Feldman R. G., Ferrante A. Prevalence of anti-group B streptococcal type III capsular IgG antibodies in the United Kingdom and an analysis of their specific IgG subclasses. J Infect Dis. 1990 Oct;162(4):883–887. doi: 10.1093/infdis/162.4.883. [DOI] [PubMed] [Google Scholar]
  8. Freijd A., Hammarström L., Persson M. A., Smith C. I. Plasma anti-pneumococcal antibody activity of the IgG class and subclasses in otitis prone children. Clin Exp Immunol. 1984 May;56(2):233–238. [PMC free article] [PubMed] [Google Scholar]
  9. French M. A., Harrison G. Systemic antibody deficiency in patients without serum immunoglobulin deficiency or with selective IgA deficiency. Clin Exp Immunol. 1984 Apr;56(1):18–22. [PMC free article] [PubMed] [Google Scholar]
  10. Hunter S. W., Gaylord H., Brennan P. J. Structure and antigenicity of the phosphorylated lipopolysaccharide antigens from the leprosy and tubercle bacilli. J Biol Chem. 1986 Sep 15;261(26):12345–12351. [PubMed] [Google Scholar]
  11. Lipsky P. E., Hirohata S., Jelinek D. F., McAnally L., Splawski J. B. Regulation of human B lymphocyte responsiveness. Scand J Rheumatol Suppl. 1988;76:229–235. doi: 10.3109/03009748809102973. [DOI] [PubMed] [Google Scholar]
  12. Ljunggren K., Broliden P. A., Morfeldt-Månson L., Jondal M., Wahren B. IgG subclass response to HIV in relation to antibody-dependent cellular cytotoxicity at different clinical stages. Clin Exp Immunol. 1988 Sep;73(3):343–347. [PMC free article] [PubMed] [Google Scholar]
  13. Mathiesen T., Sönnerborg A., von Sydow M., Gaines H., Wahren B. IgG subclass reactivity against human immunodeficiency virus (HIV) and cytomegalovirus in cerebrospinal fluid and serum from HIV-infected patients. J Med Virol. 1988 May;25(1):17–26. doi: 10.1002/jmv.1890250104. [DOI] [PubMed] [Google Scholar]
  14. Merrett J., Burr M. L., Merrett T. G. A community survey of IgG4 antibody levels. Clin Allergy. 1983 Sep;13(5):397–407. doi: 10.1111/j.1365-2222.1983.tb02615.x. [DOI] [PubMed] [Google Scholar]
  15. Moreno C., Taverne J., Mehlert A., Bate C. A., Brealey R. J., Meager A., Rook G. A., Playfair J. H. Lipoarabinomannan from Mycobacterium tuberculosis induces the production of tumour necrosis factor from human and murine macrophages. Clin Exp Immunol. 1989 May;76(2):240–245. [PMC free article] [PubMed] [Google Scholar]
  16. Nüsslein H. G., Spiegelberg H. L. Interleukin-4 induces both IgG4 and IgE secretion by peripheral blood B cells. J Clin Lab Anal. 1990;4(6):414–419. doi: 10.1002/jcla.1860040605. [DOI] [PubMed] [Google Scholar]
  17. Parkin J. M., Helbert M., Hughes C. L., Pinching A. J. Immunoglobulin G subclass deficiency and susceptibility to pyogenic infections in patients with AIDS-related complex and AIDS. AIDS. 1989 Jan;3(1):37–39. [PubMed] [Google Scholar]
  18. Pitchenik A. E., Cole C., Russell B. W., Fischl M. A., Spira T. J., Snider D. E., Jr Tuberculosis, atypical mycobacteriosis, and the acquired immunodeficiency syndrome among Haitian and non-Haitian patients in south Florida. Ann Intern Med. 1984 Nov;101(5):641–645. doi: 10.7326/0003-4819-101-5-641. [DOI] [PubMed] [Google Scholar]
  19. Quinti I., Papetti C., von Hunolstein C., Orefici G., Aiuti F. IgG subclasses to group B streptococci in normals, colonized woman and IgG2 subclass-deficient patients. Monogr Allergy. 1988;23:148–155. [PubMed] [Google Scholar]
  20. Riesen W. F., Skvaril F., Braun D. G. Natural infection of man with group A streptococci. Levels; restriction in class, subclass, and type; and clonal appearance of polysaccharide-group-specific antibodies. Scand J Immunol. 1976;5(4):383–390. doi: 10.1111/j.1365-3083.1976.tb00292.x. [DOI] [PubMed] [Google Scholar]
  21. Rynnel-Dagö B., Freijd A., Hammarström L., Oxelius V., Persson M. A., Smith C. I. Pneumococcal antibodies of different immunoglobulin subclasses in normal and IgG subclass deficient individuals of various ages. Acta Otolaryngol. 1986 Jan-Feb;101(1-2):146–151. doi: 10.3109/00016488609108617. [DOI] [PubMed] [Google Scholar]
  22. Sarvas H., Rautonen N., Sipinen S., Mäkelä O. IgG subclasses of pneumococcal antibodies--effect of allotype G2m(n). Scand J Immunol. 1989 Feb;29(2):229–237. doi: 10.1111/j.1365-3083.1989.tb01120.x. [DOI] [PubMed] [Google Scholar]
  23. Spiegelberg H. L., Falkoff R. J., O'Connor R. D., Beck L. Interleukin-2 inhibits the interleukin-4-induced human IgE and IgG4 secretion in vivo. Clin Exp Immunol. 1991 Jun;84(3):400–405. [PMC free article] [PubMed] [Google Scholar]
  24. Splawski J. B., Jelinek D. F., Lipsky P. E. Immunomodulatory role of IL-4 on the secretion of Ig by human B cells. J Immunol. 1989 Mar 1;142(5):1569–1575. [PubMed] [Google Scholar]
  25. Sundqvist V. A., Linde A., Kurth R., Werner A., Helm E. B., Popovic M., Gallo R. C., Wahren B. Restricted IgG subclass responses to HTLV-III/LAV and to cytomegalovirus in patients with AIDS and lymphadenopathy syndrome. J Infect Dis. 1986 May;153(5):970–973. doi: 10.1093/infdis/153.5.970. [DOI] [PubMed] [Google Scholar]
  26. Woof J. M., Partridge L. J., Jefferis R., Burton D. R. Localisation of the monocyte-binding region on human immunoglobulin G. Mol Immunol. 1986 Mar;23(3):319–330. doi: 10.1016/0161-5890(86)90059-3. [DOI] [PubMed] [Google Scholar]
  27. van der Giessen M., Rossouw E., van Veen T. A., van Loghem E., Zegers B. J., Sander P. C. Quantification of IgG subclasses in sera of normal adults and healthy children between 4 and 12 years of age. Clin Exp Immunol. 1975 Sep;21(3):501–509. [PMC free article] [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES