Skip to main content
PMC home page
Immunology logoLink to Immunology
. 1981 Jun;43(2):293–301.

A lack of correlation between antigen-specific cellular reactions and resistance to Mycobacterium lepraemurium infection in mice.

J Curtis, H O Adu, J L Turk
PMCID: PMC1555020  PMID: 7019051

Abstract

Following infection subcutaneously in the footpad with 10(7) Mycobacterium lepraemurium organisms C57BL mice were able to limit multiplication of organisms at the infection site for the 6 months studied and to limit organism spread to the draining lymph node. Large numbers of organisms were present in the footpad and draining lymph node of BALB/c mice at 6 months. In spite of this difference in local immunity the changes in cellular reactivity to specific antigen as assessed by the delayed footpad response and the in vitro proliferative response of draining lymph node cells were similar in the two strains over the time studied.

Full text

PDF
295

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alexander J. Adoptive transfer of immunity and suppression by cells and serum in early Mycobacterium lepraemurium infections of mice. Parasite Immunol. 1979 Summer;1(2):159–166. doi: 10.1111/j.1365-3024.1979.tb00703.x. [DOI] [PubMed] [Google Scholar]
  2. Alexander J., Curtis J. Development of delayed hypersensitivity responses in Mycobacterium lepraemurium infections in resistant and susceptible strains of mice. Immunology. 1979 Mar;36(3):563–567. [PMC free article] [PubMed] [Google Scholar]
  3. Bjune G., Barnetson R. S., Ridley D. S., Kronvall G. Lymphocyte transformation test in leprosy; correlation of the response with inflammation of lesions. Clin Exp Immunol. 1976 Jul;25(1):85–94. [PMC free article] [PubMed] [Google Scholar]
  4. Closs O. Experimental murine leprosy: growth of Mycobacterium lepraemurium in C3H and C57/BL mice after footpad inoculation. Infect Immun. 1975 Sep;12(3):480–489. doi: 10.1128/iai.12.3.480-489.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Closs O. Experimental murine leprosy: induction of immunity and immune paralysis to Mycobacterium lepraemurium in C57BL mice. Infect Immun. 1975 Oct;12(4):706–713. doi: 10.1128/iai.12.4.706-713.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Curtis J., Turk J. L. Mitsuda-type lepromin reactions as a measure of host resistance in Mycobacterium lepraemurium infection. Infect Immun. 1979 May;24(2):492–500. doi: 10.1128/iai.24.2.492-500.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. HART P. D., REES R. J. Effect of macrocyclon in acute and chronic pulmonary tuberculous infection in mice as shown by viable and total bacterial counts. Br J Exp Pathol. 1960 Aug;41:414–421. [PMC free article] [PubMed] [Google Scholar]
  8. Lagrange P. H., Hurtrel B. Local immune response to Mycobacterium lepraemurium in C3H and C57Bl/6 mice. Clin Exp Immunol. 1979 Dec;38(3):461–474. [PMC free article] [PubMed] [Google Scholar]
  9. McMurray D. N., Echeverri A. Cell-mediated immunity in anergic patients with pulmonary tuberculosis. Am Rev Respir Dis. 1978 Nov;118(5):827–834. doi: 10.1164/arrd.1978.118.5.827. [DOI] [PubMed] [Google Scholar]
  10. Myrvang B., Godal T., Ridley D. S., Fröland S. S., Song Y. K. Immune responsiveness to Mycobacterium leprae and other mycobacterial antigens throughout the clinical and histopathological spectrum of leprosy. Clin Exp Immunol. 1973 Aug;14(4):541–553. [PMC free article] [PubMed] [Google Scholar]
  11. Poulter L. W., Lefford M. J. Relationship between delayed-type hypersensitivity and the progression of Mycobacterium lepraemurium infection. Infect Immun. 1978 May;20(2):530–540. doi: 10.1128/iai.20.2.530-540.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Rook G. A. The immunological consequences of antigen overload in experimental mycobacterial infections of mice. Clin Exp Immunol. 1975 Jan;19(1):167–177. [PMC free article] [PubMed] [Google Scholar]
  13. Rook G. A. The potentiating, mitogenic and inhibitory effects on lymphocytes in vitro, of macrophages in the lymph nodes of mice 'overloaded' with mycobacterial products. Clin Exp Immunol. 1975 Jul;21(1):163–172. [PMC free article] [PubMed] [Google Scholar]
  14. Turcotte R. Influence of route of Mycobacterium lepraemurium injection on susceptibility to mouse leprosy and on lymphoblastic transformation. Infect Immun. 1980 Jun;28(3):660–668. doi: 10.1128/iai.28.3.660-668.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Youmans G. P. Relation between delayed hypersensitivity and immunity in tuberculosis. Am Rev Respir Dis. 1975 Feb;111(2):109–118. doi: 10.1164/arrd.1975.111.2.109. [DOI] [PubMed] [Google Scholar]

Articles from Immunology are provided here courtesy of British Society for Immunology

RESOURCES