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. 1981 Aug;43(4):747–754.

T-cell hybridomas producing hapten-specific suppressor factors.

S Kontiainen, E J Culbert, M Cecka, E Simpson, I F McKenzie, M Feldmann
PMCID: PMC1555090  PMID: 6168565

Abstract

We have made several T-T hybridomas which secrete soluble factors capable of suppressing an in vitro antibody response to nitrophenol (NP), but not other unrelated antigens. These factors bind specifically to NP, and express determinants coded for in the I-J region of the mouse major histocompatibility complex. No determinants that cross-react with the constant regions of mouse immunoglobulins are present on the factors. Three sub-clones originating from the same initial culture well of hybridoma cells secrete factors which carry I-J determinants of different haplotypes. One clone expresses I-J determinants derived from the suppressor cell parent, another expresses I-J determinants derived from the tumour cell parent, and a third expresses both. This correlates exactly with I-J determinants expressed on the cell membrane, and suggests the participation of at least two genes in the determination of suppressor-factor structure.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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