Skip to main content
PMC home page
Immunology logoLink to Immunology
. 1982 Feb;45(2):217–225.

Preparation and characterization of the anti-idiotypic properties of rabbit anti-timothy antigen B helper factor and anti-mouse timothy IgE antisera.

A Malley, C J Brandt, L B Deppe
PMCID: PMC1555265  PMID: 6174420

Abstract

with AgB-primed B or T cells and injected into syngeneic X-irradiated recipients. Anti-THF and anti-Eid purified by an AgB-specific T suppressor factor (TSF) affi-gel adsorbent retain their ability to specifically initiate [3H]-thymidine incorporation of AgB-primed T cells. The data indicate that both anti-THF and anti-Eid recognize unique determinants present on AgB-specific T-helper, T-suppressor and B cells, and suggest that the receptors on AgB-specific T and B cells share cross-reactive idiotypic determinants.

Full text

PDF
217

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bach B. A., Greene M. I., Benacerraf B., Nisonoff A. Mechanisms of regulation of cell-mediated immunity. IV. Azobenzenearsonate-specific suppressor factor(s) bear cross-reactive idiotypic determinants the expression of which is linked to the heavy-chain allotype linkage group of genes. J Exp Med. 1979 May 1;149(5):1084–1098. doi: 10.1084/jem.149.5.1084. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Binz H., Wigzell H. Antigen-binding, idiotypic T-lymphocyte receptors. Contemp Top Immunobiol. 1977;7:113–177. doi: 10.1007/978-1-4684-3054-7_4. [DOI] [PubMed] [Google Scholar]
  3. Bona C., Hooghe R., Cazenave P. A., Leguérn C., Paul W. E. Cellular basis of regulation of expression of idiotype. II. Immunity to anti-MOPC-460 idiotype antibodies increases the level of anti-trinitrophenyl antibodies bearing 460 idiotypes. J Exp Med. 1979 Apr 1;149(4):815–823. doi: 10.1084/jem.149.4.815. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Bottomly K., Mathieson B. J., Mosier D. E. Anti-idiotype induced regulation of helper cell function for the response to phosphorylcholine in adult BALB/c mice. J Exp Med. 1978 Nov 1;148(5):1216–1227. doi: 10.1084/jem.148.5.1216. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Cosenza H., Augustin A. A., Julius M. H. Idiotypes and anti-idiotypes as probes in analysis of immunoregulation. Cold Spring Harb Symp Quant Biol. 1977;41(Pt 2):709–718. doi: 10.1101/sqb.1977.041.01.081. [DOI] [PubMed] [Google Scholar]
  6. Eichmann K. Expression and function of idiotypes of lymphocytes. Adv Immunol. 1978;26:195–254. doi: 10.1016/s0065-2776(08)60231-x. [DOI] [PubMed] [Google Scholar]
  7. Eichmann K., Rajewsky K. Induction of T and B cell immunity by anti-idiotypic antibody. Eur J Immunol. 1975 Oct;5(10):661–666. doi: 10.1002/eji.1830051002. [DOI] [PubMed] [Google Scholar]
  8. Fairchild S. S., Malley A. Induction of mouse homocytotropic antibodies to Timothy pollen antigens. J Immunol. 1975 Aug;115(2):446–449. [PubMed] [Google Scholar]
  9. Fairchild S. S., Malley A. Mouse B and T lymphocyte responses to purified timothy pollen antigens in vitro. J Immunol. 1976 Dec;117(6):2137–2142. [PubMed] [Google Scholar]
  10. Fairchild S. S., Malley A. Response of mouse splenic lymphocytes to timothy pollen antigens in a microculture system. J Immunol. 1975 Dec;115(6):1533–1537. [PubMed] [Google Scholar]
  11. Julius M. H., Simpson E., Herzenberg L. A. A rapid method for the isolation of functional thymus-derived murine lymphocytes. Eur J Immunol. 1973 Oct;3(10):645–649. doi: 10.1002/eji.1830031011. [DOI] [PubMed] [Google Scholar]
  12. Malley A., Baecher L., Begley D. Preliminary characterization of a major allergen of timothy grass pollen. Dev Biol Stand. 1975;29:29–40. [PubMed] [Google Scholar]
  13. Malley A., Baecher L., Begley D. The chemical characterization of a major allergen of timothy pollen. Immunochemistry. 1975 Jul;12(6-7):551–554. doi: 10.1016/0019-2791(75)90083-x. [DOI] [PubMed] [Google Scholar]
  14. Malley A., Begley D. E., Forsham A. T-cell-priming characteristics of modified timothy grass pollen antigen B1. Int Arch Allergy Appl Immunol. 1980;62(3):276–284. doi: 10.1159/000232523. [DOI] [PubMed] [Google Scholar]
  15. Malley A., Begley D., Forsham A. Chemical modification of timothy grass pollen antigen B--I. Loss of antibody binding properties. Mol Immunol. 1979 Nov;16(11):929–934. doi: 10.1016/0161-5890(79)90093-2. [DOI] [PubMed] [Google Scholar]
  16. Malley A., Begley D., Forsham A. Preparation of high titered rabbit anti-mouse IgE sera. Immunol Commun. 1977;6(5):473–482. doi: 10.3109/08820137709094146. [DOI] [PubMed] [Google Scholar]
  17. Malley A., Harris R. L., Jr Biologic properties of a non-precipitating antigen from timothy pollen extracts. J Immunol. 1967 Oct;99(4):825–830. [PubMed] [Google Scholar]
  18. March S. C., Parikh I., Cuatrecasas P. A simplified method for cyanogen bromide activation of agarose for affinity chromatography. Anal Biochem. 1974 Jul;60(1):149–152. doi: 10.1016/0003-2697(74)90139-0. [DOI] [PubMed] [Google Scholar]
  19. Rajewsky K., Eichmann K. Antigen receptors of T helper cells. Contemp Top Immunobiol. 1977;7:69–112. doi: 10.1007/978-1-4684-3054-7_3. [DOI] [PubMed] [Google Scholar]
  20. Wysocki L. J., Sato V. L. "Panning" for lymphocytes: a method for cell selection. Proc Natl Acad Sci U S A. 1978 Jun;75(6):2844–2848. doi: 10.1073/pnas.75.6.2844. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Yamamoto H., Nonaka M., Katz D. H. Suppression of hapten-specific delayed-type hypersensitivity responses in mice by idiotype-specific suppressor T cells after administration of anti-idiotypic antibodies. J Exp Med. 1979 Oct 1;150(4):818–829. doi: 10.1084/jem.150.4.818. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Immunology are provided here courtesy of British Society for Immunology

RESOURCES