Abstract
The ability of mice with circulating endogenous antigen-antibody complexes to clear and localize heat-aggregated rabbit IgG and a covalently linked tetramer of rabbit IgG anti-IgG was compared with that of normal mice. Although the clearance rates of both probes were unchanged their localization was altered. Hepatic localization in all mice with endogenous complexes was reduced. In some mice, splenic localization was also reduced whereas the amounts in the kidney were increased. These changes could not be attributed to alterations in the blood content of these organs as this was the same as that of normal mice. It is suggested that the observed differences result from saturation of a section of the mononuclear phagocyte system (MPS) with accelerated handling of complexes by mesangial cells in the kidney.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Elema J. D., Hoyer J. R., Vernier R. L. The glomerular mesangium: uptake and transport of intravenously injected colloidal carbon in rats. Kidney Int. 1976 May;9(5):395–406. doi: 10.1038/ki.1976.49. [DOI] [PubMed] [Google Scholar]
- Essien F. B., Jorgensen A. O., Kalnins V. I., Zubrzycka E., MacLennan D. H. The biosynthesis and localization of sarcoplasmic reticulum proteins in dysgenic (mdg/mdg) mouse cells. Lab Invest. 1977 Dec;37(6):562–568. [PubMed] [Google Scholar]
- Finbloom D. S., Abeles D., Rifai A., Plotz P. H. The specificity of uptake of model immune complexes and other protein aggregates by the murine reticuloendothelial system. J Immunol. 1980 Sep;125(3):1060–1065. [PubMed] [Google Scholar]
- Frank M. M., Hamburger M. I., Lawley T. J., Kimberly R. P., Plotz P. H. Defective reticuloendothelial system Fc-receptor function in systemic lupus erythematosus. N Engl J Med. 1979 Mar 8;300(10):518–523. doi: 10.1056/NEJM197903083001002. [DOI] [PubMed] [Google Scholar]
- Grace S. A., Elson C. J. Continuous production of anti-host IgG antibodies contained in circulating IgG-anti-IgG complexes. Immunology. 1982 Oct;47(2):289–296. [PMC free article] [PubMed] [Google Scholar]
- Haakenstad A. O., Mannik M. Saturation of the reticuloendothelial system with soluble immune complexes. J Immunol. 1974 May;112(5):1939–1948. [PubMed] [Google Scholar]
- Michael A. F., Fish A. J., Good R. A. Glomerular localization and transport of aggregated proteins in mice. Lab Invest. 1967 Jul;17(1):14–29. [PubMed] [Google Scholar]
- Scott D. G., Bacon P. A., Allen C., Elson C. J., Wallington T. IgG rheumatoid factor, complement and immune complexes in rheumatoid synovitis and vasculitis: comparative and serial studies during cytotoxic therapy. Clin Exp Immunol. 1981 Jan;43(1):54–63. [PMC free article] [PubMed] [Google Scholar]