Skip to main content
PMC home page
Immunology logoLink to Immunology
. 1982 Dec;47(4):581–587.

The relationship of HLA-B and DR phenotypes to Behcet's syndrome, recurrent oral ulceration and the class of immune complexes.

T Lehner, K I Welsh, J R Batchelor
PMCID: PMC1555564  PMID: 6958639

Abstract

A series of eighty Caucasian patients was divided into four groups with the mucocutaneous, arthritic, neurological and ocular types of Behcet's syndrome (BS) and a fifth group of patients with recurrent oral ulcers. The immunogenetic basis of the four types of BS was extended from HLA-B locus to the DR locus. Whereas B5 and more precisely the Bw51 split is the most discriminating marker of the ocular type of BS, DR7 also shows a significant increase in the ocular and neurological types. Indeed, most if not all patients with the ocular type have B5 and/or DR7. B12 and/or DR2 is significantly increased at the less severe end of the spectrum, the mucocutaneous and arthritic types. Patients with recurrent oral ulcers also show an increase in B12 and/or DR2. However, B12 and/or DR7 shows an increase in the relative risk in all four types of BS. These results suggest that HLA-B12, B5, DR7 and DR2 might in some way be associated with tissue localization of disease. Alternatively, since patients with HLA-B12 show a significantly greater ratio of IgG:IgA circulating immune complexes than those with B5/DR7/DR2, tissue localization might be influenced by the immune complex isotype. A significant relationship was also found between the MT2 and MT3 B cell alloantigen system and BS, with particular reference to MT2 and the neurological type and MT3 and the ocular type of BS.

Full text

PDF
584

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Burton-Kee J. E., Mowbray J. F., Lehner T. Different cross-reacting circulating immune complexes in Behçet's syndrome and recurrent oral ulcers. J Lab Clin Med. 1981 Apr;97(4):559–567. [PubMed] [Google Scholar]
  2. Challacombe S. J., Batchelor J. R., Kennedy L. A., Lehner T. HLA antigens in recurrent oral ulceration. Arch Dermatol. 1977 Dec;113(12):1717–1719. doi: 10.1001/archderm.1977.01640120085019. [DOI] [PubMed] [Google Scholar]
  3. Haim S., Gideoni O., Barzilai A. The histocompatibility antigens in patients with Behçet's disease. Acta Derm Venereol. 1977;57(3):243–245. [PubMed] [Google Scholar]
  4. Joysey V. C., Wolf E. HLA-A, -B and -C antigens, their serology and cross-reaction. Br Med Bull. 1978 Sep;34(3):217–222. doi: 10.1093/oxfordjournals.bmb.a071501. [DOI] [PubMed] [Google Scholar]
  5. Lehner T., Batchelor J. R., Challacombe S. J., Kennedy L. An immunogenetic basis for the tissue involvement in Behçet's syndrome. Immunology. 1979 Aug;37(4):895–900. [PMC free article] [PubMed] [Google Scholar]
  6. Lehner T., Losito A., Williams D. G. Cryoglobulins in Behçet's syndrome and recurrent oral ulceration: assay by laser nephelometry. Clin Exp Immunol. 1979 Dec;38(3):436–444. [PMC free article] [PubMed] [Google Scholar]
  7. Lehner T., Welsh K. L., Batchelor J. R. Relationship of HLA phenotype to immunoglobulin class present in immune complexes from patients with Behçet's syndrome. Tissue Antigens. 1981;17(4):357–361. doi: 10.1111/j.1399-0039.1981.tb00715.x. [DOI] [PubMed] [Google Scholar]
  8. Ohno S., Asanuma T., Sugiura S., Wakisaka A., Aizawa M., Itakura K. HLA-Bw51 and Behçet's disease. JAMA. 1978 Aug 11;240(6):529–529. [PubMed] [Google Scholar]
  9. Perkins E. S. Epidemiology of uveitis. Trans Ophthalmol Soc U K. 1976 Apr;96(1):105–107. [PubMed] [Google Scholar]
  10. Svejgaard A., Jersild C., Nielsen L. S., Bodmer W. F. HL-A antigens and disease. Statistical and genetical considerations. Tissue Antigens. 1974;4(2):95–105. doi: 10.1111/j.1399-0039.1974.tb00230.x. [DOI] [PubMed] [Google Scholar]
  11. VAN ROOD J. J., VAN LEEUWEN A. LEUKOCYTE GROUPING. A METHOD AND ITS APPLICATION. J Clin Invest. 1963 Sep;42:1382–1390. doi: 10.1172/JCI104822. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Van Epps D. E., Reed K., Williams R. C., Jr Suppression of human PMN bactericidal activity by human IgA paraproteins. Cell Immunol. 1978 Mar 15;36(2):363–376. doi: 10.1016/0008-8749(78)90280-0. [DOI] [PubMed] [Google Scholar]
  13. Van Epps D. E., Williams R. C., Jr Suppression of leukocyte chemotaxis by human IgA myeloma components. J Exp Med. 1976 Nov 2;144(5):1227–1242. doi: 10.1084/jem.144.5.1227. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Yazici H., Akokan G., Yalçin B., Müftüoğlu A. The high prevalence of HLA-B5 in Behçet's disease. Clin Exp Immunol. 1977 Nov;30(2):259–261. [PMC free article] [PubMed] [Google Scholar]
  15. Yazici H., Chamberlain M. A., Schreuder I., D'Amaro J., Muftuoglu M. HLA antigens in Behçet's disease: a reappraisal by a comparative study of Turkish and British patients. Ann Rheum Dis. 1980 Aug;39(4):344–348. doi: 10.1136/ard.39.4.344. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Immunology are provided here courtesy of British Society for Immunology

RESOURCES