Abstract
Environmental pollution is a complex issue because of the diversity of anthropogenic agents, both chemical and physical, that have been detected and catalogued. The consequences to biota from exposure to genotoxic agents present an additional problem because of the potential for these agents to produce adverse change at the cellular and organismal levels. Past studies in genetic toxicology at the Oak Ridge National Laboratory have focused on structural damage to the DNA of environmental species that may occur after exposure to genotoxic agents and the use of this information to document exposure and to monitor remediation. In an effort to predict effects at the population, community, and ecosystem levels, current studies in genetic ecotoxicology are attempting to characterize the biologic mechanisms at the gene level that regulate and limit the response of an individual organism to genotoxic factors in their environment.
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Selected References
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- Cicerone R. J. Changes in stratospheric ozone. Science. 1987 Jul 3;237(4810):35–42. doi: 10.1126/science.237.4810.35. [DOI] [PubMed] [Google Scholar]
- Kohn K. W. The significance of DNA-damage assays in toxicity and carcinogenicity assessment. Ann N Y Acad Sci. 1983;407:106–118. doi: 10.1111/j.1749-6632.1983.tb47817.x. [DOI] [PubMed] [Google Scholar]
- Lamb T., Bickham J. W., Gibbons J. W., Smolen M. J., McDowell S. Genetic damage in a population of slider turtles (Trachemys scripta) inhabiting a radioactive reservoir. Arch Environ Contam Toxicol. 1991 Jan;20(1):138–142. doi: 10.1007/BF01065340. [DOI] [PubMed] [Google Scholar]
- Martineau D., Lagacé A., Béland P., Higgins R., Armstrong D., Shugart L. R. Pathology of stranded beluga whales (Delphinapterus leucas) from the St. Lawrence Estuary, Québec, Canada. J Comp Pathol. 1988 Apr;98(3):287–311. doi: 10.1016/0021-9975(88)90038-2. [DOI] [PubMed] [Google Scholar]
- Shugart L. R., McCarthy J. F., Halbrook R. S. Biological markers of environmental and ecological contamination: an overview. Risk Anal. 1992 Sep;12(3):353–360. doi: 10.1111/j.1539-6924.1992.tb00687.x. [DOI] [PubMed] [Google Scholar]
- Shugart L., Holland J. M., Rahn R. O. Dosimetry of PAH skin carcinogenesis: covalent binding of benzo[a]pyrene to mouse epidermal DNA. Carcinogenesis. 1983;4(2):195–198. doi: 10.1093/carcin/4.2.195. [DOI] [PubMed] [Google Scholar]
- Wogan G. N., Gorelick N. J. Chemical and biochemical dosimetry of exposure to genotoxic chemicals. Environ Health Perspect. 1985 Oct;62:5–18. doi: 10.1289/ehp.85625. [DOI] [PMC free article] [PubMed] [Google Scholar]