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. 1994 Dec;102(Suppl 11):89–95. doi: 10.1289/ehp.94102s1189

Chemical contaminants, pharmacokinetics, and the lactating mother.

W J Rogan 1, N B Ragan 1
PMCID: PMC1566754  PMID: 7737048

Abstract

We review the commonly occurring persistent pesticides and industrial chemicals in breast milk. These chemicals are dichlorodiphenyl trichloroethane as dichlorodiphenyl dichloroethene dieldrin, chlordane as oxychlordane, heptachlor, polychlorinated biphenyls, polychlorinated dibenzofurans, and polychlorinated dibenzodioxins. We present a worked example of the kinds of pharmacokinetic assumptions and calculations necessary for setting regulatory limits of contaminants in the food supply, calculating dose of chemical contaminants to the nursed infant, converting risks from lifetime exposure in laboratory animals to risks for short-term exposure in humans, and estimating the excess cancer risk to the nursed infant.

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Selected References

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  1. Anderson L. M., Ward J. M., Fox S. D., Isaaq H. J., Riggs C. W. Effects of a single dose of polychlorinated biphenyls to infant mice on N-nitrosodimethylamine-initiated lung and liver tumors. Int J Cancer. 1986 Jul 15;38(1):109–116. doi: 10.1002/ijc.2910380118. [DOI] [PubMed] [Google Scholar]
  2. Anderson L. M., van Havere K., Budinger J. M. Effects of polychlorinated biphenyls on lung and liver tumors initiated in suckling mice by N-nitrosodimethylamine. J Natl Cancer Inst. 1983 Jul;71(1):157–163. [PubMed] [Google Scholar]
  3. Bevenue A. The "bioconcentration" aspects of DDT in the environment. Residue Rev. 1976;61:37–112. doi: 10.1007/978-1-4613-9401-3_3. [DOI] [PubMed] [Google Scholar]
  4. Bradt P. T., Herrenkohl R. C. DDT in human milk. What determines the levels? Sci Total Environ. 1976 Sep;6(2):161–163. doi: 10.1016/0048-9697(76)90011-5. [DOI] [PubMed] [Google Scholar]
  5. Fein G. G., Jacobson J. L., Jacobson S. W., Schwartz P. M., Dowler J. K. Prenatal exposure to polychlorinated biphenyls: effects on birth size and gestational age. J Pediatr. 1984 Aug;105(2):315–320. doi: 10.1016/s0022-3476(84)80139-0. [DOI] [PubMed] [Google Scholar]
  6. Ferguson B. B., Wilson D. J., Schaffner W. Determination of nicotine concentrations in human milk. Am J Dis Child. 1976 Aug;130(8):837–839. doi: 10.1001/archpedi.1976.02120090047008. [DOI] [PubMed] [Google Scholar]
  7. Frisancho A. R. New standards of weight and body composition by frame size and height for assessment of nutritional status of adults and the elderly. Am J Clin Nutr. 1984 Oct;40(4):808–819. doi: 10.1093/ajcn/40.4.808. [DOI] [PubMed] [Google Scholar]
  8. Gartrell M. J., Craun J. C., Podrebarac D. S., Gunderson E. L. Pesticides, selected elements, and other chemicals in adult total diet samples, October 1980-March 1982. J Assoc Off Anal Chem. 1986 Jan-Feb;69(1):146–159. [PubMed] [Google Scholar]
  9. Gladen B. C., Rogan W. J., Hardy P., Thullen J., Tingelstad J., Tully M. Development after exposure to polychlorinated biphenyls and dichlorodiphenyl dichloroethene transplacentally and through human milk. J Pediatr. 1988 Dec;113(6):991–995. doi: 10.1016/s0022-3476(88)80569-9. [DOI] [PubMed] [Google Scholar]
  10. Hsu S. T., Ma C. I., Hsu S. K., Wu S. S., Hsu N. H., Yeh C. C., Wu S. B. Discovery and epidemiology of PCB poisoning in Taiwan: a four-year followup. Environ Health Perspect. 1985 Feb;59:5–10. doi: 10.1289/ehp.59-1568088. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Jacobson S. W., Fein G. G., Jacobson J. L., Schwartz P. M., Dowler J. K. The effect of intrauterine PCB exposure on visual recognition memory. Child Dev. 1985 Aug;56(4):853–860. [PubMed] [Google Scholar]
  12. Jason J. Breast-feeding in 1991. N Engl J Med. 1991 Oct 3;325(14):1036–1038. doi: 10.1056/NEJM199110033251409. [DOI] [PubMed] [Google Scholar]
  13. Jensen A. A. Chemical contaminants in human milk. Residue Rev. 1983;89:1–128. doi: 10.1007/978-1-4612-5601-4_1. [DOI] [PubMed] [Google Scholar]
  14. Kutz F. W., Yobs A. R., Strassman S. C. Racial stratification of organochlorine insecticide residues in human adipose tissue. J Occup Med. 1977 Sep;19(9):619–622. [PubMed] [Google Scholar]
  15. LAUG E. P., KUNZE F. M., PRICKETT C. S. Occurrence of DDT in human fat and milk. AMA Arch Ind Hyg Occup Med. 1951 Mar;3(3):245–246. [PubMed] [Google Scholar]
  16. Livingston J. M., Jones C. R. Living area contamination by chlordane used for termite treatment. Bull Environ Contam Toxicol. 1981 Sep;27(3):406–411. doi: 10.1007/BF01611040. [DOI] [PubMed] [Google Scholar]
  17. Masuda Y., Kuroki H., Haraguchi K., Nagayama J. PCB and PCDF congeners in the blood and tissues of yusho and yu-cheng patients. Environ Health Perspect. 1985 Feb;59:53–58. doi: 10.1289/ehp.59-1568081. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Mattison D. R., Wohlleb J., To T., Lamb Y., Faitak S., Brewster M. A., Walls R. C., Selevan S. G. Pesticide concentrations in Arkansas breast milk. J Ark Med Soc. 1992 Apr;88(11):553–557. [PubMed] [Google Scholar]
  19. McKinney J. D., Moore L., Prokopetz A., Walters D. B. Validated extraction and cleanup procedures for polychlorinated biphenyls and DDE in human body fluids and infant formula. J Assoc Off Anal Chem. 1984 Jan-Feb;67(1):122–129. [PubMed] [Google Scholar]
  20. Mennella J. A., Beauchamp G. K. Maternal diet alters the sensory qualities of human milk and the nursling's behavior. Pediatrics. 1991 Oct;88(4):737–744. [PubMed] [Google Scholar]
  21. Mennella J. A., Beauchamp G. K. The transfer of alcohol to human milk. Effects on flavor and the infant's behavior. N Engl J Med. 1991 Oct 3;325(14):981–985. doi: 10.1056/NEJM199110033251401. [DOI] [PubMed] [Google Scholar]
  22. O'Leary J. A., Davies J. E., Edmundson W. F., Feldman M. Correlation of prematurity and DDE levels in fetal whole blood. Am J Obstet Gynecol. 1970 Mar 15;106(6):939–939. doi: 10.1016/0002-9378(70)90499-0. [DOI] [PubMed] [Google Scholar]
  23. Rogan W. J., Blanton P. J., Portier C. J., Stallard E. Should the presence of carcinogens in breast milk discourage breast feeding? Regul Toxicol Pharmacol. 1991 Jun;13(3):228–240. doi: 10.1016/0273-2300(91)90065-4. [DOI] [PubMed] [Google Scholar]
  24. Rogan W. J., Gladen B. C., Hung K. L., Koong S. L., Shih L. Y., Taylor J. S., Wu Y. C., Yang D., Ragan N. B., Hsu C. C. Congenital poisoning by polychlorinated biphenyls and their contaminants in Taiwan. Science. 1988 Jul 15;241(4863):334–336. doi: 10.1126/science.3133768. [DOI] [PubMed] [Google Scholar]
  25. Rogan W. J., Gladen B. C., McKinney J. D., Carreras N., Hardy P., Thullen J., Tingelstad J., Tully M. Polychlorinated biphenyls (PCBs) and dichlorodiphenyl dichloroethene (DDE) in human milk: effects of maternal factors and previous lactation. Am J Public Health. 1986 Feb;76(2):172–177. doi: 10.2105/ajph.76.2.172. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Rogan W. J., Gladen B. C., McKinney J. D., Carreras N., Hardy P., Thullen J., Tingelstad J., Tully M. Polychlorinated biphenyls (PCBs) and dichlorodiphenyl dichloroethene (DDE) in human milk: effects on growth, morbidity, and duration of lactation. Am J Public Health. 1987 Oct;77(10):1294–1297. doi: 10.2105/ajph.77.10.1294. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Rogan W. J., Gladen B. C., McKinney J. D., Carreras N., Hardy P., Thullen J., Tinglestad J., Tully M. Neonatal effects of transplacental exposure to PCBs and DDE. J Pediatr. 1986 Aug;109(2):335–341. doi: 10.1016/s0022-3476(86)80397-3. [DOI] [PubMed] [Google Scholar]
  28. Rogan W. J., Gladen B. C. Study of human lactation for effects of environmental contaminants: the North Carolina Breast Milk and Formula Project and some other ideas. Environ Health Perspect. 1985 May;60:215–221. doi: 10.1289/ehp.8560215. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Savage E. P., Keefe T. J., Tessari J. D., Wheeler H. W., Applehans F. M., Goes E. A., Ford S. A. National study of chlorinated hydrocarbon insecticide residues in human milk, USA. I. Geographic distribution of dieldrin, heptachlor, heptachlor epoxide, chlordane, oxychlordane, and mirex. Am J Epidemiol. 1981 Apr;113(4):413–422. doi: 10.1093/oxfordjournals.aje.a113109. [DOI] [PubMed] [Google Scholar]
  30. Smith R. J. Hawaiian milk contamination creates alarm. A sour response by state regulators. Science. 1982 Jul 9;217(4555):137–140. doi: 10.1126/science.7089547. [DOI] [PubMed] [Google Scholar]
  31. Stehr-Green P. A., Wohlleb J. C., Royce W., Head S. L. An evaluation of serum pesticide residue levels and liver function in persons exposed to dairy products contaminated with heptachlor. JAMA. 1988 Jan 15;259(3):374–377. [PubMed] [Google Scholar]
  32. Taguchi S., Yakushiji T. Influence of termite treatment in the home on the chlordane concentration in human milk. Arch Environ Contam Toxicol. 1988 Jan;17(1):65–71. doi: 10.1007/BF01055155. [DOI] [PubMed] [Google Scholar]
  33. Takahashi W., Saidin D., Takei G., Wong L. Organochloride pesticide residues in human milk in Hawaii, 1979-80. Bull Environ Contam Toxicol. 1981 Oct;27(4):506–511. doi: 10.1007/BF01611056. [DOI] [PubMed] [Google Scholar]
  34. Tilson H. A., Jacobson J. L., Rogan W. J. Polychlorinated biphenyls and the developing nervous system: cross-species comparisons. Neurotoxicol Teratol. 1990 May-Jun;12(3):239–248. doi: 10.1016/0892-0362(90)90095-t. [DOI] [PubMed] [Google Scholar]
  35. Wassermann M., Ron M., Bercovici B., Wassermann D., Cucos S., Pines A. Premature delivery and organochlorine compounds: polychlorinated biphenyls and some organochlorine insecticides. Environ Res. 1982 Jun;28(1):106–112. doi: 10.1016/0013-9351(82)90158-x. [DOI] [PubMed] [Google Scholar]
  36. Wilson J. T., Brown R. D., Hinson J. L., Dailey J. W. Pharmacokinetic pitfalls in the estimation of the breast milk/plasma ratio for drugs. Annu Rev Pharmacol Toxicol. 1985;25:667–689. doi: 10.1146/annurev.pa.25.040185.003315. [DOI] [PubMed] [Google Scholar]

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