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. 1994 Jan;102(1):74–77. doi: 10.1289/ehp.9410274

Human Milk as a Source of Methylmercury Exposure in Infants.

P Grandjean 1, PJ Jørgensen 1, P Weihe 1
PMCID: PMC1567218  PMID: 9719671

Abstract

As methylmercury is excreted in human milk and infants are particularly susceptible to toxicity due to this compound, the purpose of this study was to evaluate the possible transfer of methylmercury to infants via breast-feeding. In a community with a high intake of seafood, 583 children from a birth cohort were followed. The duration of nursing was recorded, and hair samples were obtained for mercury analysis at approximately 12 months of age. The hair mercury concentrations increased with the length of the nursing period, and those nursed throughout the first year showed the highest geometric mean (9.0 nmol/g or 1.8 microg/g). Human milk therefore seems to be an important source of methylmercury exposure in infants. An increasing time interval from weaning to hair sample collection was not associated with any detectable decrease in mercury concentrations. A slow or absent elimination of methylmercury during the first year after birth could explain this finding. In certain fishing communities, infants nursed for long periods may be at increased risk of developing methylmercury toxicity.

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Selected References

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  1. Amin-Zaki L., Elhassani S., Majeed M. A., Clarkson T. W., Doherty R. A., Greenwood M. R., Giovanoli-Jakubczak T. Perinatal methylmercury poisoning in Iraq. Am J Dis Child. 1976 Oct;130(10):1070–1076. doi: 10.1001/archpedi.1976.02120110032004. [DOI] [PubMed] [Google Scholar]
  2. Amin-Zaki L., Elhassani S., Majeed M. A., Clarkson T. W., Doherty R. A., Greenwood M. R. Studies of infants postnatally exposed to methylmercury. J Pediatr. 1974 Jul;85(1):81–84. doi: 10.1016/s0022-3476(74)80291-x. [DOI] [PubMed] [Google Scholar]
  3. Amin-Zaki L., Majeed M. A., Greenwood M. R., Elhassani S. B., Clarkson T. W., Doherty R. A. Methylmercury poisoning in the Iraqi suckling infant: a longitudinal study over five years. J Appl Toxicol. 1981 Aug;1(4):210–214. doi: 10.1002/jat.2550010405. [DOI] [PubMed] [Google Scholar]
  4. Andersen A., Julshamn K., Ringdal O., Mørkøre J. Trace elements intake in the Faroe Islands. II. Intake of mercury and other elements by consumption of pilot whales (Globicephalus meleanus). Sci Total Environ. 1987 Sep;65:63–68. doi: 10.1016/0048-9697(87)90161-6. [DOI] [PubMed] [Google Scholar]
  5. Bakir F., Damluji S. F., Amin-Zaki L., Murtadha M., Khalidi A., al-Rawi N. Y., Tikriti S., Dahahir H. I., Clarkson T. W., Smith J. C. Methylmercury poisoning in Iraq. Science. 1973 Jul 20;181(4096):230–241. doi: 10.1126/science.181.4096.230. [DOI] [PubMed] [Google Scholar]
  6. Clemente G. F., Ingrao G., Santaroni G. P. The concentration of some trace elements in human milk from Italy. Sci Total Environ. 1982 Aug;24(3):255–265. doi: 10.1016/0048-9697(82)90004-3. [DOI] [PubMed] [Google Scholar]
  7. Fujita M., Takabatake E. Mercury levels in human maternal and neonatal blood, hair and milk. Bull Environ Contam Toxicol. 1977 Aug;18(2):205–209. doi: 10.1007/BF01686068. [DOI] [PubMed] [Google Scholar]
  8. Galster W. A. Mercury in Alaskan Eskimo mothers and infants. Environ Health Perspect. 1976 Jun;15:135–140. doi: 10.1289/ehp.7615135. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Grandjean P., Weihe P., Jørgensen P. J., Clarkson T., Cernichiari E., Viderø T. Impact of maternal seafood diet on fetal exposure to mercury, selenium, and lead. Arch Environ Health. 1992 May-Jun;47(3):185–195. doi: 10.1080/00039896.1992.9938348. [DOI] [PubMed] [Google Scholar]
  10. Kojima K., Fujita M. Summary of recent studies in Japan on methyl mercury poisoning. Toxicology. 1973 Mar;1(1):43–62. doi: 10.1016/0300-483x(73)90017-6. [DOI] [PubMed] [Google Scholar]
  11. Kosta L., Byrne A. R., Dermelj M. Trace elements in some human milk samples by radiochemical neutron activation analysis. Sci Total Environ. 1983 Aug;29(3):261–268. doi: 10.1016/0048-9697(83)90095-5. [DOI] [PubMed] [Google Scholar]
  12. Pineau A., Piron M., Boiteau H. L., Etourneau M. J., Guillard O. Determination of total mercury in human hair samples by cold vapor atomic absorption spectrometry. J Anal Toxicol. 1990 Jul-Aug;14(4):235–238. doi: 10.1093/jat/14.4.235. [DOI] [PubMed] [Google Scholar]
  13. Rowland I. R. Factors affecting metabolic activity of the intestinal microflora. Drug Metab Rev. 1988;19(3-4):243–261. doi: 10.3109/03602538808994135. [DOI] [PubMed] [Google Scholar]
  14. Rowland I. R., Robinson R. D., Doherty R. A. Effects of diet on mercury metabolism and excretion in mice given methylmercury: role of gut flora. Arch Environ Health. 1984 Nov-Dec;39(6):401–408. doi: 10.1080/00039896.1984.10545872. [DOI] [PubMed] [Google Scholar]
  15. Skerfving S. Mercury in women exposed to methylmercury through fish consumption, and in their newborn babies and breast milk. Bull Environ Contam Toxicol. 1988 Oct;41(4):475–482. doi: 10.1007/BF02020989. [DOI] [PubMed] [Google Scholar]
  16. Suda I., Hirayama K. Degradation of methyl and ethyl mercury into inorganic mercury by hydroxyl radical produced from rat liver microsomes. Arch Toxicol. 1992;66(6):398–402. doi: 10.1007/BF02035129. [DOI] [PubMed] [Google Scholar]
  17. Sundberg J., Oskarsson A., Albanus L. Methylmercury exposure during lactation: milk concentration and tissue uptake of mercury in the neonatal rat. Bull Environ Contam Toxicol. 1991 Feb;46(2):255–262. doi: 10.1007/BF01691946. [DOI] [PubMed] [Google Scholar]

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