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. 1994 Jan;102(1):64–73. doi: 10.1289/ehp.9410264

Carcinogenic and Cocarcinogenic Effects of Radon and Radon Daughters in Rats.

G Monchaux 1, JP Morlier 1, M Morin 1, J Chameaud 1, J Lafuma 1, R Masse 1
PMCID: PMC1567245  PMID: 9719670

Abstract

It has been previously established that lung cancer could be induced in rats by exposure to radon and radon daughters. Although the oat-cell carcinomas that are common in humans were not found in rats, other histological types of lung carcinomas, especially squamous cell carcinomas and primitive lung adenocarcinomas, were similar to those observed in humans. A dose-effect relationship was established for cumulative doses varying from 25 to 3000 working-level-months (WLM), which was similar for medium and high cumulative doses to that observed in uranium miners. This experimental protocol was also used to study the potential cocarcinogenic effects of other environmental or industrial airborne pollutants such as tobacco smoke, mineral fibers, diesel exhausts, or minerals from metallic mine ores that may act synergistically with radon exposure. In rats exposed to radon and tobacco smoke combined, the incidence of lung cancers was higher by a factor of 2-4 according to the cumulative radon exposure and the duration of tobacco smoke exposure. When mineral fibers were injected intrapleurally, an increased incidence of malignant thoracic tumors was observed in rats exposed to radon and fibers combined, but synergistic effects resulted in additivity. With diesel exhausts or minerals from metallic ores, a slight, nonsignificant increase in the incidence of lung carcinomas was observed compared with rats exposed to radon alone. These results demonstrated that it is possible to establish the potential cocarcinogenic action, showing either multiplicative, additive, or no effect of various environmental or industrial airborne pollutants combined with radon exposure. This radon model is valid for investigating possible interactions between two occupational exposures.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Archer V. E. Comment on 'A histologic study of the influence of cigarette smoking in suppressing Rn daughter carcinogenesis in dogs'. Health Phys. 1989 Feb;56(2):255–256. [PubMed] [Google Scholar]
  2. Archer V. E., Wagoner J. K., Lundin F. E. Lung cancer among uranium miners in the United States. Health Phys. 1973 Oct;25(4):351–371. doi: 10.1097/00004032-197310000-00001. [DOI] [PubMed] [Google Scholar]
  3. Bignon J., Monchaux G., Chameaud J., Jaurand M. C., Lafuma J., Masse R. Incidence of various types of thoracic malignancy induced in rats by intrapleural injection of 2 mg of various mineral dusts after inhalation of 222Ra. Carcinogenesis. 1983;4(5):621–628. doi: 10.1093/carcin/4.5.621. [DOI] [PubMed] [Google Scholar]
  4. Brenner D. J. Radon: current challenges in cellular radiobiology. Int J Radiat Biol. 1992 Jan;61(1):3–13. doi: 10.1080/09553009214550561. [DOI] [PubMed] [Google Scholar]
  5. Cross F. T., Palmer R. F., Filipy R. E., Dagle G. E., Stuart B. O. Carcinogenic effects of radon daughters, uranium ore dust and cigarette smoke in beagle dogs. Health Phys. 1982 Jan;42(1):33–52. doi: 10.1097/00004032-198201000-00004. [DOI] [PubMed] [Google Scholar]
  6. Edling C. Lung cancer and smoking in a group of iron ore miners. Am J Ind Med. 1982;3(2):191–199. doi: 10.1002/ajim.4700030210. [DOI] [PubMed] [Google Scholar]
  7. Fox A. J., Goldlbatt P., Kinlen L. J. A study of the mortality of Cornish tin miners. Br J Ind Med. 1981 Nov;38(4):378–380. doi: 10.1136/oem.38.4.378. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. GROSS P., TOLKER E., BABYAK M. A., KASCHAK M. EXPERIMENTAL LUNG CANCER IN HAMSTERS. REPETITIVE INTRATRACHEAL APPLICATIONS OF TWO CARCINOGENIC HYDROCARBONS. Arch Environ Health. 1965 Jul;11:59–65. doi: 10.1080/00039896.1965.10664170. [DOI] [PubMed] [Google Scholar]
  9. Garshick E., Schenker M. B., Muñoz A., Segal M., Smith T. J., Woskie S. R., Hammond S. K., Speizer F. E. A case-control study of lung cancer and diesel exhaust exposure in railroad workers. Am Rev Respir Dis. 1987 Jun;135(6):1242–1248. doi: 10.1164/arrd.1987.135.6.1242. [DOI] [PubMed] [Google Scholar]
  10. Garshick E., Schenker M. B., Muñoz A., Segal M., Smith T. J., Woskie S. R., Hammond S. K., Speizer F. E. A retrospective cohort study of lung cancer and diesel exhaust exposure in railroad workers. Am Rev Respir Dis. 1988 Apr;137(4):820–825. doi: 10.1164/ajrccm/137.4.820. [DOI] [PubMed] [Google Scholar]
  11. Gies R. A., Cross F. T., Dagle G. E. A histologic study of the influence of cigarette smoking in suppressing Rn daughter carcinogenesis in dogs. Health Phys. 1987 Nov;53(5):527–529. [PubMed] [Google Scholar]
  12. Heinrich U., Muhle H., Takenaka S., Ernst H., Fuhst R., Mohr U., Pott F., Stöber W. Chronic effects on the respiratory tract of hamsters, mice and rats after long-term inhalation of high concentrations of filtered and unfiltered diesel engine emissions. J Appl Toxicol. 1986 Dec;6(6):383–395. doi: 10.1002/jat.2550060602. [DOI] [PubMed] [Google Scholar]
  13. Hirano T., Stanton M., Layard M. Measurement of epidermoid carcinoma development induced in the lungs of rats by 3-methylcholanthrene-containing beeswax pellets. J Natl Cancer Inst. 1974 Nov;53(5):1209–1209. doi: 10.1093/jnci/53.5.1209. [DOI] [PubMed] [Google Scholar]
  14. Howe G. R., Nair R. C., Newcombe H. B., Miller A. B., Abbatt J. D. Lung cancer mortality (1950-80) in relation to radon daughter exposure in a cohort of workers at the Eldorado Beaverlodge uranium mine. J Natl Cancer Inst. 1986 Aug;77(2):357–362. [PubMed] [Google Scholar]
  15. Jorgensen H. S. Lung cancer among underground workers in the iron ore mine of Kiruna based on thirty years of observation. Ann Acad Med Singapore. 1984 Apr;13(2 Suppl):371–377. [PubMed] [Google Scholar]
  16. Mauderly J. L., Jones R. K., Griffith W. C., Henderson R. F., McClellan R. O. Diesel exhaust is a pulmonary carcinogen in rats exposed chronically by inhalation. Fundam Appl Toxicol. 1987 Aug;9(2):208–221. doi: 10.1016/0272-0590(87)90044-3. [DOI] [PubMed] [Google Scholar]
  17. Mercer R. R., Russell M. L., Crapo J. D. Radon dosimetry based on the depth distribution of nuclei in human and rat lungs. Health Phys. 1991 Jul;61(1):117–130. doi: 10.1097/00004032-199107000-00013. [DOI] [PubMed] [Google Scholar]
  18. Monchaux G., Bignon J., Jaurand M. C., Lafuma J., Sebastien P., Masse R., Hirsch A., Goni J. Mesotheliomas in rats following inoculation with acid-leached chrysotile asbestos and other mineral fibres. Carcinogenesis. 1981;2(3):229–236. doi: 10.1093/carcin/2.3.229. [DOI] [PubMed] [Google Scholar]
  19. Morgan A., Davies P., Wagner J. C., Berry G., Holmes A. The biological effects of magnesium-leached chrysotile asbestos. Br J Exp Pathol. 1977 Oct;58(5):465–473. [PMC free article] [PubMed] [Google Scholar]
  20. Morlier J. P., Morin M., Chameaud J., Masse R., Bottard S., Lafuma J. Importance du rôle du débit de dose sur l'apparition des cancers chez le rat après inhalation de radon. C R Acad Sci III. 1992;315(12):463–466. [PubMed] [Google Scholar]
  21. Pezerat H., Zalma R., Guignard J., Jaurand M. C. Production of oxygen radicals by the reduction of oxygen arising from the surface activity of mineral fibres. IARC Sci Publ. 1989;(90):100–111. [PubMed] [Google Scholar]
  22. Pham Q. T., Gaertner M., Mur J. M., Braun P., Gabiano M., Sadoul P. Incidence of lung cancer among iron miners. Eur J Respir Dis. 1983 Oct;64(7):534–540. [PubMed] [Google Scholar]
  23. Quéval P., Beaumatin J., Morin M., Courtois D., Lafuma J. Inducibility of microsomal enzymes in normal and pre-cancerous lung tissue. Synergistic action of 5-6 benzoflavon or methyl-cholanthrene in radiation induced carcinogenesis. Biomedicine. 1979 Oct;31(6):182–186. [PubMed] [Google Scholar]
  24. Radford E. P., Renard K. G. Lung cancer in Swedish iron miners exposed to low doses of radon daughters. N Engl J Med. 1984 Jun 7;310(23):1485–1494. doi: 10.1056/NEJM198406073102302. [DOI] [PubMed] [Google Scholar]
  25. Saccomanno G., Huth G. C., Auerbach O., Kuschner M. Relationship of radioactive radon daughters and cigarette smoking in the genesis of lung cancer in uranium miners. Cancer. 1988 Oct 1;62(7):1402–1408. doi: 10.1002/1097-0142(19881001)62:7<1402::aid-cncr2820620727>3.0.co;2-k. [DOI] [PubMed] [Google Scholar]
  26. Samet J. M., Pathak D. R., Morgan M. V., Key C. R., Valdivia A. A., Lubin J. H. Lung cancer mortality and exposure to radon progeny in a cohort of New Mexico underground uranium miners. Health Phys. 1991 Dec;61(6):745–752. doi: 10.1097/00004032-199112000-00005. [DOI] [PubMed] [Google Scholar]
  27. Samet J. M., Pathak D. R., Morgan M. V., Marbury M. C., Key C. R., Valdivia A. A. Radon progeny exposure and lung cancer risk in New Mexico U miners: a case-control study. Health Phys. 1989 Apr;56(4):415–421. doi: 10.1097/00004032-198904000-00002. [DOI] [PubMed] [Google Scholar]
  28. Sevc J., Kunz E., Placek V. Lung cancer in uranium miners and long-term exposure to radon daughter products. Health Phys. 1976 Jun;30(6):433–437. doi: 10.1097/00004032-197606000-00001. [DOI] [PubMed] [Google Scholar]
  29. Solli H. M., Andersen A., Stranden E., Langård S. Cancer incidence among workers exposed to radon and thoron daughters at a niobium mine. Scand J Work Environ Health. 1985 Feb;11(1):7–13. doi: 10.5271/sjweh.2261. [DOI] [PubMed] [Google Scholar]
  30. Thomas J. W. Measurement of radon daughters in air. Health Phys. 1972 Dec;23(6):783–789. doi: 10.1097/00004032-197212000-00004. [DOI] [PubMed] [Google Scholar]
  31. Wagner J. C., Berry G., Timbrell V. Mesotheliomata in rats after inoculation with asbestos and other materials. Br J Cancer. 1973 Aug;28(2):173–185. doi: 10.1038/bjc.1973.134. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Witschi H., Williamson D., Lock S. Enhancement of urethan tumorigenesis in mouse lung by butylated hydroxytoluene. J Natl Cancer Inst. 1977 Feb;58(2):301–305. doi: 10.1093/jnci/58.2.301. [DOI] [PubMed] [Google Scholar]

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