Skip to main content
PMC home page
Environmental Health Perspectives logoLink to Environmental Health Perspectives
. 1989 Feb;79:121–126. doi: 10.1289/ehp.8979121

Factors affecting the response of lung clearance systems to acid aerosols: role of exposure concentration, exposure time, and relative acidity.

R B Schlesinger 1
PMCID: PMC1567568  PMID: 2707191

Abstract

The ability of the lungs to clear deposited material is essential for maintenance of lung homeostasis. Acid aerosols have been shown to alter the efficiency of this process. This paper assesses the role of acid aerosol exposure concentration (C), exposure time (T), and relative acidity in producing changes in clearance from both the tracheobronchial tree and respiratory region of the lungs of rabbits. The response was found to be due to total exposure, i.e., some combination form of C x T, and was also related to relative acidity.

Full text

PDF
125

Images in this article

125FIGURE 5.
on p.125

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AMDUR M. O., SCHULZ R. Z., DRINKER P. Toxicity of sulfuric acid mist to guinea pigs. AMA Arch Ind Hyg Occup Med. 1952 Apr;5(4):318–329. [PubMed] [Google Scholar]
  2. Amdur M. O., Bayles J., Ugro V., Underhill D. W. Comparative irritant potency of sulfate salts. Environ Res. 1978 Jul;16(1-3):1–8. doi: 10.1016/0013-9351(78)90135-4. [DOI] [PubMed] [Google Scholar]
  3. Schlesinger R. B., Chen L. C., Driscoll K. E. Exposure-response relationship of bronchial mucociliary clearance in rabbits following acute inhalations of sulfuric acid mist. Toxicol Lett. 1984 Aug;22(2):249–254. doi: 10.1016/0378-4274(84)90074-2. [DOI] [PubMed] [Google Scholar]
  4. Schlesinger R. B. Clearance from the respiratory tract. Fundam Appl Toxicol. 1985 Jun;5(3):435–450. doi: 10.1016/0272-0590(85)90091-0. [DOI] [PubMed] [Google Scholar]
  5. Schlesinger R. B. Comparative irritant potency of inhaled sulfate aerosols--effects on bronchial mucociliary clearance. Environ Res. 1984 Aug;34(2):268–279. doi: 10.1016/0013-9351(84)90095-1. [DOI] [PubMed] [Google Scholar]
  6. Schlesinger R. B., Gearhart J. M. Early alveolar clearance in rabbits intermittently exposed to sulfuric acid mist. J Toxicol Environ Health. 1986;17(2-3):213–220. doi: 10.1080/15287398609530817. [DOI] [PubMed] [Google Scholar]
  7. Schlesinger R. B., Lippmann M., Albert R. E. Effects of short-term exposures to sulfuric acid and ammonium sulfate aerosols upon bronchial airway function in the donkey. Am Ind Hyg Assoc J. 1978 Apr;39(4):275–286. doi: 10.1080/0002889778507759. [DOI] [PubMed] [Google Scholar]
  8. Schlesinger R. B., Naumann B. D., Chen L. C. Physiological and histological alterations in the bronchial mucociliary clearance system of rabbits following intermittent oral or nasal inhalation of sulfuric acid mist. J Toxicol Environ Health. 1983 Aug-Sep;12(2-3):441–465. doi: 10.1080/15287398309530440. [DOI] [PubMed] [Google Scholar]
  9. Schlesinger R. B., Naumann B., Chen L. C. A system for measurement of radioactive aerosol retention in the lungs of rabbits. Health Phys. 1982 Jan;42(1):73–77. [PubMed] [Google Scholar]
  10. Schlesinger R. B., Vollmuth T. A., Naumann B. D., Driscoll K. E. Measurement of particle clearance from the alveolar region of the rabbit respiratory tract. Fundam Appl Toxicol. 1986 Aug;7(2):256–263. doi: 10.1016/0272-0590(86)90155-7. [DOI] [PubMed] [Google Scholar]
  11. Utell M. J., Morrow P. E., Hyde R. W. Comparison of normal and asthmatic subjects' responses to sulphate pollutant aerosols. Ann Occup Hyg. 1982;26(1-4):691–697. [PubMed] [Google Scholar]

Articles from Environmental Health Perspectives are provided here courtesy of National Institute of Environmental Health Sciences

RESOURCES