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. 1989 Feb;79:195–199. doi: 10.1289/ehp.8979195

Human health effects of exposure to airborne acid.

L J Folinsbee 1
PMCID: PMC1567569  PMID: 2707199

Abstract

This paper summarizes and critiques a series of reports on the health effects of acid aerosol exposure, presented at the Symposium on the Health Effects of Acid Aerosols and compares these data to selected previous studies. The role of the two major defenses against acid aerosols, the conversion of acid to the ammonium salts by respiratory ammonia and buffering of acid by airway surface liquid are discussed in relation to airway acid burdens expected from typical inhalation exposures. The roles of particle size and hygroscopicity on airway deposition of aerosol are also included. The major health effects studied were the effects of acid aerosol on mucociliary clearance in healthy individuals and changes in lung function in asthmatics, an important sensitive subpopulation. The broad range of response in asthmatics suggests the need for further study.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Avol E. L., Jones M. P., Bailey R. M., Chang N. M., Kleinman M. T., Linn W. S., Bell K. A., Hackney J. D. Controlled exposures of human volunteers to sulfate aerosols. Health effects and aerosol characterization. Am Rev Respir Dis. 1979 Aug;120(2):319–327. doi: 10.1164/arrd.1979.120.2.319. [DOI] [PubMed] [Google Scholar]
  2. Balmes J. R., Fine J. M., Gordon T., Sheppard D. Potential bronchoconstrictor stimuli in acid fog. Environ Health Perspect. 1989 Feb;79:163–166. doi: 10.1289/ehp.8979163. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bowes S. M., 3rd, Laube B. L., Links J. M., Frank R. Regional deposition of inhaled fog droplets: preliminary observations. Environ Health Perspect. 1989 Feb;79:151–157. doi: 10.1289/ehp.8979151. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Cocks A. T., McElroy W. J. Modeling studies of the concurrent growth and neutralization of sulfuric acid aerosols under conditions in the human airways. Environ Res. 1984 Oct;35(1):79–96. doi: 10.1016/0013-9351(84)90115-4. [DOI] [PubMed] [Google Scholar]
  5. Fine J. M., Gordon T., Thompson J. E., Sheppard D. The role of titratable acidity in acid aerosol-induced bronchoconstriction. Am Rev Respir Dis. 1987 Apr;135(4):826–830. doi: 10.1164/arrd.1987.135.4.826. [DOI] [PubMed] [Google Scholar]
  6. Hackney J. D., Linn W. S., Avol E. L. Acid fog: effects on respiratory function and symptoms in healthy and asthmatic volunteers. Environ Health Perspect. 1989 Feb;79:159–162. doi: 10.1289/ehp.8979159. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Holma B. Effects of inhaled acids on airway mucus and its consequences for health. Environ Health Perspect. 1989 Feb;79:109–113. doi: 10.1289/ehp.8979109. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Holma B. Influence of buffer capacity and pH-dependent rheological properties of respiratory mucus on health effects due to acidic pollution. Sci Total Environ. 1985 Feb;41(2):101–123. doi: 10.1016/0048-9697(85)90181-0. [DOI] [PubMed] [Google Scholar]
  9. Holma B., Lindegren M., Andersen J. M. pH effects on ciliomotility and morphology of respiratory mucosa. Arch Environ Health. 1977 Sep-Oct;32(5):216–226. doi: 10.1080/00039896.1977.10667285. [DOI] [PubMed] [Google Scholar]
  10. Koenig J. Q., Covert D. S., Pierson W. E. Effects of inhalation of acidic compounds on pulmonary function in allergic adolescent subjects. Environ Health Perspect. 1989 Feb;79:173–178. doi: 10.1289/ehp.8979173. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Koenig J. Q., Morgan M. S., Horike M., Pierson W. E. The effects of sulfur oxides on nasal and lung function in adolescents with extrinsic asthma. J Allergy Clin Immunol. 1985 Dec;76(6):813–818. doi: 10.1016/0091-6749(85)90754-7. [DOI] [PubMed] [Google Scholar]
  12. Koenig J. Q., Pierson W. E., Horike M. The effects of inhaled sulfuric acid on pulmonary function in adolescent asthmatics. Am Rev Respir Dis. 1983 Aug;128(2):221–225. doi: 10.1164/arrd.1983.128.2.221. [DOI] [PubMed] [Google Scholar]
  13. Larson T. V., Frank R., Covert D. S., Holub D., Morgan M. S. Measurements of respiratory ammonia and the chemical neutralization of inhaled sulfuric acid aerosol in anesthetized dogs. Am Rev Respir Dis. 1982 May;125(5):502–506. doi: 10.1164/arrd.1982.125.5.502. [DOI] [PubMed] [Google Scholar]
  14. Leikauf G. D., Spektor D. M., Albert R. E., Lippmann M. Dose-dependent effects of submicrometer sulfuric acid aerosol on particle clearance from ciliated human lung airways. Am Ind Hyg Assoc J. 1984 May;45(5):285–292. doi: 10.1080/15298668491399802. [DOI] [PubMed] [Google Scholar]
  15. Leikauf G., Yeates D. B., Wales K. A., Spektor D., Albert R. E., Lippmann M. Effects of sulfuric acid aerosol on respiratory mechanics and mucociliary particle clearance in healthy nonsmoking adults. Am Ind Hyg Assoc J. 1981 Apr;42(4):273–282. doi: 10.1080/15298668191419721. [DOI] [PubMed] [Google Scholar]
  16. Linn W. S., Avol E. L., Shamoo D. A., Whynot J. D., Anderson K. R., Hackney J. D. Respiratory responses of exercising asthmatic volunteers exposed to sulfuric acid aerosol. J Air Pollut Control Assoc. 1986 Dec;36(12):1323–1328. doi: 10.1080/00022470.1986.10466181. [DOI] [PubMed] [Google Scholar]
  17. Raizenne M. E., Burnett R. T., Stern B., Franklin C. A., Spengler J. D. Acute lung function responses to ambient acid aerosol exposures in children. Environ Health Perspect. 1989 Feb;79:179–185. doi: 10.1289/ehp.8979179. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Spektor D. M., Leikauf G. D., Albert R. E., Lippmann M. Effects of submicrometer sulfuric acid aerosols on mucociliary transport and respiratory mechanics in asymptomatic asthmatics. Environ Res. 1985 Jun;37(1):174–191. doi: 10.1016/0013-9351(85)90056-8. [DOI] [PubMed] [Google Scholar]
  19. Spektor D. M., Yen B. M., Lippmann M. Effect of concentration and cumulative exposure of inhaled sulfuric acid on tracheobronchial particle clearance in healthy humans. Environ Health Perspect. 1989 Feb;79:167–172. doi: 10.1289/ehp.8979167. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Utell M. J., Morrow P. E., Speers D. M., Darling J., Hyde R. W. Airway responses to sulfate and sulfuric acid aerosols in asthmatics. An exposure-response relationship. Am Rev Respir Dis. 1983 Sep;128(3):444–450. doi: 10.1164/arrd.1983.128.3.444. [DOI] [PubMed] [Google Scholar]

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