Abstract
A tabulation of carcinogenic potency (TD50) by species for 492 chemicals that induce tumors in rats or mice is presented. With the use of the Carcinogenic Potency Database, experimental results are summarized by indicating in which sex-species groups the chemical was tested and the respective evaluations of carcinogenicity. A comparison of three summary measures of TD50 for chemicals with more than one positive experiment per species shows that the most potent TD50 value is similar to measures that average values or functions of values. This tabulation can be used to investigate associations between rodent potency and other factors such as mutagenicity, teratogenicity, chemical structure, and human exposure.
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Selected References
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- Ames B. N., Magaw R., Gold L. S. Ranking possible carcinogenic hazards. Science. 1987 Apr 17;236(4799):271–280. doi: 10.1126/science.3563506. [DOI] [PubMed] [Google Scholar]
- Bernstein L., Gold L. S., Ames B. N., Pike M. C., Hoel D. G. Some tautologous aspects of the comparison of carcinogenic potency in rats and mice. Fundam Appl Toxicol. 1985 Feb;5(1):79–86. doi: 10.1016/0272-0590(85)90051-x. [DOI] [PubMed] [Google Scholar]
- Gaylor D. W., Chen J. J. Relative potency of chemical carcinogens in rodents. Risk Anal. 1986 Sep;6(3):283–290. doi: 10.1111/j.1539-6924.1986.tb00220.x. [DOI] [PubMed] [Google Scholar]
- Gold L. S., Backman G. M., Hooper N. K., Peto R. Ranking the potential carcinogenic hazards to workers from exposures to chemicals that are tumorigenic in rodents. Environ Health Perspect. 1987 Dec;76:211–219. doi: 10.1289/ehp.8776211. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gold L. S., Bernstein L., Kaldor J., Backman G., Hoel D. An empirical comparison of methods used to estimate carcinogenic potency in long-term animal bioassays: lifetable vs summary incidence data. Fundam Appl Toxicol. 1986 Feb;6(2):263–269. doi: 10.1016/0272-0590(86)90239-3. [DOI] [PubMed] [Google Scholar]
- Gold L. S., Sawyer C. B., Magaw R., Backman G. M., de Veciana M., Levinson R., Hooper N. K., Havender W. R., Bernstein L., Peto R. A carcinogenic potency database of the standardized results of animal bioassays. Environ Health Perspect. 1984 Dec;58:9–319. doi: 10.1289/ehp.84589. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gold L. S., Slone T. H., Backman G. M., Magaw R., Da Costa M., Lopipero P., Blumenthal M., Ames B. N. Second chronological supplement to the Carcinogenic Potency Database: standardized results of animal bioassays published through December 1984 and by the National Toxicology Program through May 1986. Environ Health Perspect. 1987 Oct;74:237–329. doi: 10.1289/ehp.8774237. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gold L. S., de Veciana M., Backman G. M., Magaw R., Lopipero P., Smith M., Blumenthal M., Levinson R., Bernstein L., Ames B. N. Chronological supplement to the Carcinogenic Potency Database: standardized results of animal bioassays published through December 1982. Environ Health Perspect. 1986 Aug;67:161–200. doi: 10.1289/ehp.8667161. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Haseman J. K., Huff J. E., Zeiger E., McConnell E. E. Comparative results of 327 chemical carcinogenicity studies. Environ Health Perspect. 1987 Oct;74:229–235. doi: 10.1289/ehp.8774229. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McCann J., Gold L. S., Horn L., McGill R., Graedel T. E., Kaldor J. Statistical analysis of Salmonella test data and comparison to results of animal cancer tests. Mutat Res. 1988 May-Aug;205(1-4):183–195. doi: 10.1016/0165-1218(88)90017-1. [DOI] [PubMed] [Google Scholar]