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. 1990 Mar;84:215–216. doi: 10.1289/ehp.9084215

Third chronological supplement to the carcinogenic potency database: standardized results of animal bioassays published through December 1986 and by the National Toxicology Program through June 1987.

L S Gold 1, T H Slone 1, G M Backman 1, S Eisenberg 1, M Da Costa 1, M Wong 1, N B Manley 1, L Rohrbach 1, B N Ames 1
PMCID: PMC1567635  PMID: 2351123

Abstract

This paper is the third chronological supplement to the Carcinogenic Potency Database that first appeared in this journal in 1984. We report here results of carcinogenesis bioassays published in the general literature between January 1985 and December 1986, and in Technical Reports of the National Toxicology Program between June 1986 and June 1987. This supplement includes results of 337 long-term, chronic experiments of 121 compounds, and reports the same information about each experiment in the same plot format as the earlier papers, e.g., the species and strain of animal, the route and duration of compound administration, dose level, and other aspects of experimental protocol, histopathology, and tumor incidence, TD50 (carcinogenic potency) and its statistical significance, dose response, opinion of the author about carcinogenicity, and literature citation. The reader needs to refer to the 1984 publication for a guide to the plot of the database, a complete description of the numerical index of carcinogenic potency, and a discussion of the sources of data, the rationale for the inclusion of particular experiments and particular target sites, and the conventions adopted in summarizing the literature. The four plots of the database are to be used together as results published earlier are not repeated. In all, the four plots include results for approximately 4000 experiments on 1050 chemicals. Appendix 14 of this paper is an alphabetical index to all chemicals in the database and indicates which plot(s) each chemical appears in. A combined plot of all results from the four separate papers, that is ordered alphabetically by chemical, is available from the first author, in printed form or on computer tape or diskette.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ames B. N., Gold L. S. In reply: carcinogenic risk estimation. Science. 1988 May 20;240(4855):1045–1047. doi: 10.1126/science.240.4855.1045. [DOI] [PubMed] [Google Scholar]
  2. Ames B. N., Gold L. S. Response: paleolithic diet, evolution, and carcinogens. Science. 1987 Dec 18;238(4834):1634–1634. doi: 10.1126/science.238.4834.1634. [DOI] [PubMed] [Google Scholar]
  3. Ames B. N., Magaw R., Gold L. S. Ranking possible carcinogenic hazards. Science. 1987 Apr 17;236(4799):271–280. doi: 10.1126/science.3563506. [DOI] [PubMed] [Google Scholar]
  4. Bernstein L., Gold L. S., Ames B. N., Pike M. C., Hoel D. G. Some tautologous aspects of the comparison of carcinogenic potency in rats and mice. Fundam Appl Toxicol. 1985 Feb;5(1):79–86. doi: 10.1016/0272-0590(85)90051-x. [DOI] [PubMed] [Google Scholar]
  5. Gold L. S., Backman G. M., Hooper N. K., Peto R. Ranking the potential carcinogenic hazards to workers from exposures to chemicals that are tumorigenic in rodents. Environ Health Perspect. 1987 Dec;76:211–219. doi: 10.1289/ehp.8776211. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Gold L. S., Bernstein L., Kaldor J., Backman G., Hoel D. An empirical comparison of methods used to estimate carcinogenic potency in long-term animal bioassays: lifetable vs summary incidence data. Fundam Appl Toxicol. 1986 Feb;6(2):263–269. doi: 10.1016/0272-0590(86)90239-3. [DOI] [PubMed] [Google Scholar]
  7. Gold L. S., Bernstein L., Magaw R., Slone T. H. Interspecies extrapolation in carcinogenesis: prediction between rats and mice. Environ Health Perspect. 1989 May;81:211–219. doi: 10.1289/ehp.8981211. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Gold L. S., Sawyer C. B., Magaw R., Backman G. M., de Veciana M., Levinson R., Hooper N. K., Havender W. R., Bernstein L., Peto R. A carcinogenic potency database of the standardized results of animal bioassays. Environ Health Perspect. 1984 Dec;58:9–319. doi: 10.1289/ehp.84589. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Gold L. S., Slone T. H., Backman G. M., Magaw R., Da Costa M., Lopipero P., Blumenthal M., Ames B. N. Second chronological supplement to the Carcinogenic Potency Database: standardized results of animal bioassays published through December 1984 and by the National Toxicology Program through May 1986. Environ Health Perspect. 1987 Oct;74:237–329. doi: 10.1289/ehp.8774237. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Gold L. S., Slone T. H., Bernstein L. Summary of carcinogenic potency and positivity for 492 rodent carcinogens in the carcinogenic potency database. Environ Health Perspect. 1989 Feb;79:259–272. doi: 10.1289/ehp.8979259. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Gold L. S., Ward J. M., Bernstein L., Stern B. Association between carcinogenic potency and tumor pathology in rodent carcinogenesis bioassays. Fundam Appl Toxicol. 1986 May;6(4):677–690. doi: 10.1016/0272-0590(86)90181-8. [DOI] [PubMed] [Google Scholar]
  12. Gold L. S., Wright C., Bernstein L., deVeciana M. Reproducibility of results in "near-replicate" carcinogenesis bioassays. J Natl Cancer Inst. 1987 Jun;78(6):1149–1158. [PubMed] [Google Scholar]
  13. Gold L. S., de Veciana M., Backman G. M., Magaw R., Lopipero P., Smith M., Blumenthal M., Levinson R., Bernstein L., Ames B. N. Chronological supplement to the Carcinogenic Potency Database: standardized results of animal bioassays published through December 1982. Environ Health Perspect. 1986 Aug;67:161–200. doi: 10.1289/ehp.8667161. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. McCann J., Gold L. S., Horn L., McGill R., Graedel T. E., Kaldor J. Statistical analysis of Salmonella test data and comparison to results of animal cancer tests. Mutat Res. 1988 May-Aug;205(1-4):183–195. doi: 10.1016/0165-1218(88)90017-1. [DOI] [PubMed] [Google Scholar]
  15. Silbergeld E. K. Risk assessment. Science. 1987 Sep 18;237(4821):1399–1340. [PubMed] [Google Scholar]
  16. Stoloff L. Carcinogenicity of aflatoxins. Science. 1987 Sep 11;237(4820):1283–1284. doi: 10.1126/science.3629238. [DOI] [PubMed] [Google Scholar]

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