Abstract
Growth of normal diploid mammalian cells in vitro is strongly regulated by the actual cell density. Cell-cell contacts via specific plasma membrane glycoproteins whose glycan moieties interact with specific receptors has been found to be a main growth regulatory principle. Malignant growth is suggested to result from impaired function of these receptors.
Full text
PDF


Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bertram J. S., Faletto M. B. Requirements for and kinetics of growth arrest of neoplastic cells by confluent 10T1/2 fibroblasts induced by a specific inhibitor of cyclic adenosine 3':5'-phosphodiesterase. Cancer Res. 1985 May;45(5):1946–1952. [PubMed] [Google Scholar]
- Böhmer F. D., Lehmann W., Schmidt H. E., Langen P., Grosse R. Purification of a growth inhibitor for Ehrlich ascites mammary carcinoma cells from bovine mammary gland. Exp Cell Res. 1984 Feb;150(2):466–476. doi: 10.1016/0014-4827(84)90591-3. [DOI] [PubMed] [Google Scholar]
- Folkman J., Moscona A. Role of cell shape in growth control. Nature. 1978 Jun 1;273(5661):345–349. doi: 10.1038/273345a0. [DOI] [PubMed] [Google Scholar]
- Heimark R. L., Schwartz S. M. The role of membrane-membrane interactions in the regulation of endothelial cell growth. J Cell Biol. 1985 Jun;100(6):1934–1940. doi: 10.1083/jcb.100.6.1934. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Holley R. W., Kiernan J. A. "Contact inhibition" of cell division in 3T3 cells. Proc Natl Acad Sci U S A. 1968 May;60(1):300–304. doi: 10.1073/pnas.60.1.300. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hsu Y. M., Wang J. L. Growth control in cultured 3T3 fibroblasts. V. Purification of an Mr 13,000 polypeptide responsible for growth inhibitory activity. J Cell Biol. 1986 Feb;102(2):362–369. doi: 10.1083/jcb.102.2.362. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Keski-Oja J., Leof E. B., Lyons R. M., Coffey R. J., Jr, Moses H. L. Transforming growth factors and control of neoplastic cell growth. J Cell Biochem. 1987 Feb;33(2):95–107. doi: 10.1002/jcb.240330204. [DOI] [PubMed] [Google Scholar]
- Kinders R. J., Milenkovic A. G., Nordin P., Johnson T. C. Characterization of cell-surface glycopeptides from mouse cerebral cortex that inhibit cell growth and protein synthesis. Biochem J. 1980 Sep 15;190(3):605–614. doi: 10.1042/bj1900605. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Klarlund J. K. Transformation of cells by an inhibitor of phosphatases acting on phosphotyrosine in proteins. Cell. 1985 Jul;41(3):707–717. doi: 10.1016/s0092-8674(85)80051-9. [DOI] [PubMed] [Google Scholar]
- Koga T., Nakano S., Nakayama M., Kounoue E., Nagafuchi S., Niho Y., Yamada H. Identification and partial purification of a low-molecular-weight growth inhibitor formed by density-inhibited, tumorigenic V79 Chinese hamster cells. Cancer Res. 1986 Sep;46(9):4431–4437. [PubMed] [Google Scholar]
- Lipkin G., Knecht M. E., Rosenberg M. A potent inhibitor of normal and transformed cell growth derived from contact-inhibited cells. Cancer Res. 1978 Mar;38(3):635–643. [PubMed] [Google Scholar]
- Massagué J. The TGF-beta family of growth and differentiation factors. Cell. 1987 May 22;49(4):437–438. doi: 10.1016/0092-8674(87)90443-0. [DOI] [PubMed] [Google Scholar]
- McMahon J. B., Farrelly J. G., Iype P. T. Purification and properties of a rat liver protein that specifically inhibits the proliferation of nonmalignant epithelial cells from rat liver. Proc Natl Acad Sci U S A. 1982 Jan;79(2):456–460. doi: 10.1073/pnas.79.2.456. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Nakamura T., Yoshimoto K., Nakayama Y., Tomita Y., Ichihara A. Reciprocal modulation of growth and differentiated functions of mature rat hepatocytes in primary culture by cell--cell contact and cell membranes. Proc Natl Acad Sci U S A. 1983 Dec;80(23):7229–7233. doi: 10.1073/pnas.80.23.7229. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Natraj C. V., Datta P. Control of DNA synthesis in growing BALB/c 3T3 mouse cells by a fibroblast growth regulatory factor. Proc Natl Acad Sci U S A. 1978 Dec;75(12):6115–6119. doi: 10.1073/pnas.75.12.6115. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Oesch F., Janik-Schmitt B., Ludewig G., Glatt H., Wieser R. J. Glutaraldehyde-fixed transformed and non-transformed cells induce contact-dependent inhibition of growth in non-transformed C3H/10T1/2 mouse fibroblasts, but not in 3-methylcholanthrene-transformed cells. Eur J Cell Biol. 1987 Jun;43(3):403–407. [PubMed] [Google Scholar]
- Peterson S. W., Lerch V. Inhibition of DNA synthesis in SV3T3 cultures by isolated 3T3 plasma membranes. J Cell Biol. 1983 Jul;97(1):276–279. doi: 10.1083/jcb.97.1.276. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Raben D., Lieberman M. A., Glaser L. Growth inhibitory protein(s) in the 3T3 cell plasma membrane. Partial purification and dissociation of growth inhibitory events from inhibition of amino acid transport. J Cell Physiol. 1981 Jul;108(1):35–45. doi: 10.1002/jcp.1041080106. [DOI] [PubMed] [Google Scholar]
- Stein G. H., Atkins L. Membrane-associated inhibitor of DNA synthesis in senescent human diploid fibroblasts: characterization and comparison to quiescent cell inhibitor. Proc Natl Acad Sci U S A. 1986 Dec;83(23):9030–9034. doi: 10.1073/pnas.83.23.9030. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Weigel P. H. Rat hepatocytes bind to synthetic galactoside surfaces via a patch of asialoglycoprotein receptors. J Cell Biol. 1980 Dec;87(3 Pt 1):855–861. doi: 10.1083/jcb.87.3.855. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Whittenberger B., Glaser L. Inhibition of DNA synthesis in cultures of 3T3 cells by isolated surface membranes. Proc Natl Acad Sci U S A. 1977 Jun;74(6):2251–2255. doi: 10.1073/pnas.74.6.2251. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wieser R. J., Heck R., Oesch F. Involvement of plasma membrane glycoproteins in the contact-dependent inhibition of growth of human fibroblasts. Exp Cell Res. 1985 Jun;158(2):493–499. doi: 10.1016/0014-4827(85)90472-0. [DOI] [PubMed] [Google Scholar]
- Wieser R. J., Oesch F. Contact inhibition of growth of human diploid fibroblasts by immobilized plasma membrane glycoproteins. J Cell Biol. 1986 Aug;103(2):361–367. doi: 10.1083/jcb.103.2.361. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wieser R. J., Oesch F. Contact-dependent regulation of growth of diploid human fibroblasts is dependent upon the presence of terminal galactose residues on plasma membrane glycoproteins. Exp Cell Res. 1988 May;176(1):80–86. doi: 10.1016/0014-4827(88)90122-x. [DOI] [PubMed] [Google Scholar]
- Wieser R. J., Oesch F. Plasma membrane glycoproteins covalently bound to silica beads as a model for molecular studies of cell-cell interactions in culture. J Biochem Biophys Methods. 1987 Oct;15(1):13–21. doi: 10.1016/0165-022x(87)90058-3. [DOI] [PubMed] [Google Scholar]
- Yaoi Y. Growth-inhibitory glycopeptides obtained from the cell surface of cultured chick embryo fibroblasts. Exp Cell Res. 1984 Sep;154(1):147–154. doi: 10.1016/0014-4827(84)90675-x. [DOI] [PubMed] [Google Scholar]