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. 1989 Jul;82:267–281. doi: 10.1289/ehp.8982267

Review and update of leukemia risk potentially associated with occupational exposure to benzene.

S M Brett 1, J V Rodricks 1, V M Chinchilli 1
PMCID: PMC1568141  PMID: 2676499

Abstract

Since the 1980 U.S. Supreme Court decision on the Occupational Safety and Health Administration's (OSHA) proposal to lower the occupational benzene standard from 10 ppm to 1 ppm, numerous quantitative assessments of the leukemia risk of benzene exposure have been prepared. The primary difference between these risk assessments has been in the way in which benzene exposure has been estimated and in the models applied to describe the dose-response relationship. The more recent assessments, in attempting to estimate benzene exposures on an individual basis, and in applying models which make maximal use of the available data points, represent a substantial improvement over earlier assessments. In this paper, we will review the available risk assessments and the data upon which they are based and will present our own assessment, which builds on prior efforts. Our reevaluation of the underlying data on the cohort that we judged to be most suitable for quantitative risk analysis suggested that past assessments may have overestimated risk by a factor of 3 to 24. In addition, we will present some recently made available data of relevance to the benzene exposure histories of cohort of concern. These data provide additional suggestion that the total benzene exposure of certain members of this cohort has likely been seriously underestimated, the extent to which remains to be determined. Further analysis of these data and pursuit of additional sources to improve the characterization of the benzene exposure of this cohort appear to be warranted in order to define more precisely the benzene-leukemia dose-response relationship.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aksoy M. Different types of malignancies due to occupational exposure to benzene: a review of recent observations in Turkey. Environ Res. 1980 Oct;23(1):181–190. doi: 10.1016/0013-9351(80)90104-8. [DOI] [PubMed] [Google Scholar]
  2. Aksoy M., Erdem S., DinCol G. Leukemia in shoe-workers exposed chronically to benzene. Blood. 1974 Dec;44(6):837–841. [PubMed] [Google Scholar]
  3. Aksoy M., Erdem S., Dinçol G. Types of leukemia in chronic benzene poisoning. A study in thirty-four patients. Acta Haematol. 1976;55(2):65–72. doi: 10.1159/000207996. [DOI] [PubMed] [Google Scholar]
  4. Aksoy M. Leukemia in workers due to occupational exposure to benzene. New Istanbul Contrib Clin Sci. 1977 Sep;12(1):3–14. [PubMed] [Google Scholar]
  5. Bond G. G., McLaren E. A., Baldwin C. L., Cook R. R. An update of mortality among chemical workers exposed to benzene. Br J Ind Med. 1986 Oct;43(10):685–691. doi: 10.1136/oem.43.10.685. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Goldstein B. D. Benzene toxicity: a critical evaluation: hematotoxicity in humans. J Toxicol Environ Health Suppl. 1977;2:69–105. [PubMed] [Google Scholar]
  7. Goldstein B. D., Snyder C. A., Laskin S., Bromberg I., Albert R. E., Nelson N. Myelogenous leukemia in rodents inhaling benzene. Toxicol Lett. 1982 Oct;13(3-4):169–173. doi: 10.1016/0378-4274(82)90206-5. [DOI] [PubMed] [Google Scholar]
  8. Infante P. F., Rinsky R. A., Wagoner J. K., Young R. J. Leukaemia in benzene workers. Lancet. 1977 Jul 9;2(8028):76–78. doi: 10.1016/s0140-6736(77)90074-5. [DOI] [PubMed] [Google Scholar]
  9. Maibach H. I., Anjo D. M. Percutaneous penetration of benzene and benzene contained in solvents used in the rubber industry. Arch Environ Health. 1981 Sep-Oct;36(5):256–260. doi: 10.1080/00039896.1981.10667633. [DOI] [PubMed] [Google Scholar]
  10. Maltoni C., Conti B., Cotti G. Benzene: a multipotential carcinogen. Results of long-term bioassays performed at the Bologna Institute of Oncology. Am J Ind Med. 1983;4(5):589–630. doi: 10.1002/ajim.4700040503. [DOI] [PubMed] [Google Scholar]
  11. Maltoni C., Cotti G., Valgimigli L., Mandrioli A. Zymbal gland carcinomas in rats following exposure to benzene by inhalation. Am J Ind Med. 1982;3(1):11–16. doi: 10.1002/ajim.4700030104. [DOI] [PubMed] [Google Scholar]
  12. Maltoni C., Scarnato C. First experimental demonstration of the carcinogenic effects of benzene; long-term bioassays on Sprague-Dawley rats by oral administration. Med Lav. 1979 Sep-Oct;70(5):352–357. [PubMed] [Google Scholar]
  13. Ott M. G., Townsend J. C., Fishbeck W. A., Langner R. A. Mortality among individuals occupationally exposed to benzene. Arch Environ Health. 1978 Jan-Feb;33(1):3–10. doi: 10.1080/00039896.1978.10667299. [DOI] [PubMed] [Google Scholar]
  14. Rinsky R. A., Smith A. B., Hornung R., Filloon T. G., Young R. J., Okun A. H., Landrigan P. J. Benzene and leukemia. An epidemiologic risk assessment. N Engl J Med. 1987 Apr 23;316(17):1044–1050. doi: 10.1056/NEJM198704233161702. [DOI] [PubMed] [Google Scholar]
  15. Rinsky R. A., Young R. J., Smith A. B. Leukemia in benzene workers. Am J Ind Med. 1981;2(3):217–245. doi: 10.1002/ajim.4700020305. [DOI] [PubMed] [Google Scholar]
  16. Snyder C. A., Goldstein B. D., Sellakumar A. R., Bromberg I., Laskin S., Albert R. E. The inhalation toxicology of benzene: incidence of hematopoietic neoplasms and hematotoxicity in ARK/J and C57BL/6J mice. Toxicol Appl Pharmacol. 1980 Jun 30;54(2):323–331. doi: 10.1016/0041-008x(80)90202-1. [DOI] [PubMed] [Google Scholar]
  17. Vigliani E. C. Leukemia associated with benzene exposure. Ann N Y Acad Sci. 1976;271:143–151. doi: 10.1111/j.1749-6632.1976.tb23103.x. [DOI] [PubMed] [Google Scholar]

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