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. 1984 Mar;54:57–65. doi: 10.1289/ehp.845457

Effects of zinc, iron and copper deficiencies on cadmium in tissues of Japanese quail.

M R Fox, S H Tao, C L Stone, B E Fry Jr
PMCID: PMC1568186  PMID: 6734571

Abstract

Experiments with young Japanese quail were conducted to determine whether combined moderate deficiencies of zinc, iron and copper would cause greater uptake and tissue retention of cadmium than the single deficiencies. Birds were fed the experimental diets containing 62 ppb cadmium from hatching to 16 days of age. On day 9 each bird received a dose of 109CdCl2 in its diet. On day 10, the duodenal and jejunal-ileal tissues contained large amounts of cadmium, and there were many significant effects of treatment on cadmium-109 retention in the livers and kidneys. At day 16, zinc deficiency caused increased cadmium in the liver, whereas iron and copper deficiencies each caused increased cadmium in the kidneys. Combined deficiencies had little or no greater effect than single deficiencies and in some cases the combined effect was less than that of a single deficiency.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bremner I., Campbell J. K. The influence of dietary copper intake on the toxicity of cadmium. Ann N Y Acad Sci. 1980;355:319–332. doi: 10.1111/j.1749-6632.1980.tb21350.x. [DOI] [PubMed] [Google Scholar]
  2. Fox M. R. Cadmium bioavailability. Fed Proc. 1983 Apr;42(6):1726–1729. [PubMed] [Google Scholar]
  3. Fox M. R., Jacobs R. M., Jones A. O., Fry B. E., Jr Effects of nutritional factors on metabolism of dietary cadmium at levels similar to those of man. Environ Health Perspect. 1979 Feb;28:107–114. doi: 10.1289/ehp.7928107. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Fox M. R., Jacobs R. M., Jones A. O., Fry B. E., Jr, Stone C. L. Effects of vitamin C and iron and cadmium metabolism. Ann N Y Acad Sci. 1980;355:249–261. doi: 10.1111/j.1749-6632.1980.tb21343.x. [DOI] [PubMed] [Google Scholar]
  5. Fox M. R. Nutritional influences on metal toxicity: cadmium as a model toxic element. Environ Health Perspect. 1979 Apr;29:95–104. doi: 10.1289/ehp.792995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Huebers H. A., Huebers E., Csiba E., Rummel W., Finch C. A. The significance of transferrin for intestinal iron absorption. Blood. 1983 Feb;61(2):283–290. [PubMed] [Google Scholar]
  7. Jacobs R. M., Jones A. O., Fry B. E., Jr, Fox M. R. Decreased long-term retention of 115mCd in Japanese quail produced by a combined supplement of zinc, copper, and manganese. J Nutr. 1978 Jun;108(6):901–910. doi: 10.1093/jn/108.6.901. [DOI] [PubMed] [Google Scholar]

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