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. 1984 Jun;56:35–41. doi: 10.1289/ehp.845635

The isolated perfused lung.

R W Niemeier
PMCID: PMC1568207  PMID: 6383800

Abstract

The unique nonrespiratory functions of the lungs have become more apparent in recent years. The isolated perfused lung model offers many advantages over other methods for the study of pulmonary metabolism, xenobiotic disposition and the influence of interactions among agents of different physical forms. Detailed descriptions of the experimental preparation are elements in evaluating and comparing data from various sources but these are frequently neglected. A discussion and critique of the following elements are provided in this review in order to elucidate the typical problems one might encounter in evaluating data: perfusate type, perfusion method, construction materials, ventilation method, temperature control, surgical procedure, microbiological contamination and evaluation criteria of the preparation. Examples are given where the IPL method has been applied and suggestions are made for future research efforts.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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