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. 1985 Oct;62:303–312. doi: 10.1289/ehp.8562303

Epidemiologic evidence for an association between gasoline and kidney cancer.

P E Enterline, J Viren
PMCID: PMC1568672  PMID: 4085434

Abstract

A recent animal experiment suggests that gasoline exposure may be a cause of human kidney cancer. This is a literature review to see whether there is any epidemiologic support for these animal findings. Trends and geographic patterns in gasoline consumption and kidney cancer mortality are moderately supportive of a relationship, although this cannot be considered important evidence for a causal relationship. Most other ecological correlations are not supportive of a relationship. Eleven oil refinery populations and one population of petroleum products distribution workers have been studied. These studies taken as a group do not appear to support the notion of a relationship between gasoline exposure and kidney cancer. However, most were not designed or analyzed with this hypothesis in mind. An examination of these data which attempts to consider the ages of the populations studied provides some evidence of a small kidney cancer excess among older workers or among workers exposed for long periods. Because of the importance of gasoline and the potential for exposure by the public further study of exposed populations is needed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Armstrong B., Garrod A., Doll R. A retrospective study of renal cancer with special reference to coffee and animal protein consumption. Br J Cancer. 1976 Feb;33(2):127–136. doi: 10.1038/bjc.1976.17. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Austin S. G., Schnatter A. R. A cohort mortality study of petrochemical workers. J Occup Med. 1983 Apr;25(4):304–312. [PubMed] [Google Scholar]
  3. Blot W. J., Brinton L. A., Fraumeni J. F., Jr, Stone B. J. Cancer mortality in U.S. counties with petroleum industries. Science. 1977 Oct 7;198(4312):51–53. doi: 10.1126/science.897679. [DOI] [PubMed] [Google Scholar]
  4. Blot W. J., Fraumeni J. F., Jr Geographic patterns of renal cancer in the United States. J Natl Cancer Inst. 1979 Aug;63(2):363–366. [PubMed] [Google Scholar]
  5. Davis D. L., Bridbord K., Schneiderman M. Cancer prevention: assessing causes, exposures, and recent trends in mortality for U.S. males 1968-1978. Teratog Carcinog Mutagen. 1982;2(2):105–135. doi: 10.1002/1520-6866(1990)2:2<105::aid-tcm1770020203>3.0.co;2-i. [DOI] [PubMed] [Google Scholar]
  6. Enstrom J. E. Cancer mortality among Mormons in California during 1968--75. J Natl Cancer Inst. 1980 Nov;65(5):1073–1082. [PubMed] [Google Scholar]
  7. Gardner J. W., Lyon J. L. Cancer in Utah Mormon women by church activity level. Am J Epidemiol. 1982 Aug;116(2):258–265. doi: 10.1093/oxfordjournals.aje.a113410. [DOI] [PubMed] [Google Scholar]
  8. Gottlieb M. S., Carr J. K., Clarkson J. R. Drinking water and cancer in Louisiana. A retrospective mortality study. Am J Epidemiol. 1982 Oct;116(4):652–667. doi: 10.1093/oxfordjournals.aje.a113448. [DOI] [PubMed] [Google Scholar]
  9. Hanis N. M., Holmes T. M., Shallenberger G., Jones K. E. Epidemiologic study of refinery and chemical plant workers. J Occup Med. 1982 Mar;24(3):203–212. doi: 10.1097/00043764-198203000-00012. [DOI] [PubMed] [Google Scholar]
  10. Hanis N. M., Stavraky K. M., Fowler J. L. Cancer mortality in oil refinery workers. J Occup Med. 1979 Mar;21(3):167–174. [PubMed] [Google Scholar]
  11. Hearey C. D., Ury H., Siegelaub A., Ho M. K., Salomon H., Cella R. L. Lack of association between cancer incidence and residence near petrochemical industry in the San Francisco Bay area. J Natl Cancer Inst. 1980 Jun;64(6):1295–1299. doi: 10.1093/jnci/64.6.1295. [DOI] [PubMed] [Google Scholar]
  12. Kantor A. L., Meigs J. W., Heston J. F., Flannery J. T. Epidemiology of renal cell carcinoma in Connecticut, 1935-1973. J Natl Cancer Inst. 1976 Sep;57(3):495–500. doi: 10.1093/jnci/57.3.495. [DOI] [PubMed] [Google Scholar]
  13. Katz R. M., Jowett D. Female laundry and dry cleaning workers in Wisconsin: a mortality analysis. Am J Public Health. 1981 Mar;71(3):305–307. doi: 10.2105/ajph.71.3.305. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. King H., Locke F. B. Cancer mortality among Chinese in the United States. J Natl Cancer Inst. 1980 Nov;65(5):1141–1148. [PubMed] [Google Scholar]
  15. Lanier A. P., Blot W. J., Bender T. R., Fraumeni J. F., Jr Cancer in Alaskan Indians, Eskimos, and Aleuts. J Natl Cancer Inst. 1980 Nov;65(5):1157–1159. [PubMed] [Google Scholar]
  16. Marsh G. M. Mortality among workers from a plastics producing plant: a matched case-control study nested in a retrospective cohort study. J Occup Med. 1983 Mar;25(3):219–230. doi: 10.1097/00043764-198303000-00017. [DOI] [PubMed] [Google Scholar]
  17. Menck H. R., Henderson B. E., Pike M. C., Mack T., Martin S. P., SooHoo J. Cancer incidence in the Mexican-American. J Natl Cancer Inst. 1975 Sep;55(3):531–536. doi: 10.1093/jnci/55.3.531. [DOI] [PubMed] [Google Scholar]
  18. Morgenstern H. Uses of ecologic analysis in epidemiologic research. Am J Public Health. 1982 Dec;72(12):1336–1344. doi: 10.2105/ajph.72.12.1336. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Redmond C. K., Ciocco A., Lloyd J. W., Rush H. W. Long-term mortality study of steelworkers. VI. Mortality from malignant neoplasms among coke oven workers. J Occup Med. 1972 Aug;14(8):621–629. [PubMed] [Google Scholar]
  20. Rushton L., Alderson M. R. An epidemiological survey of eight oil refineries in Britain. Br J Ind Med. 1981 Aug;38(3):225–234. doi: 10.1136/oem.38.3.225. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Seidman H. Cancer death rates by site and sex for religious and socioeconomic groups in New York City. Environ Res. 1970 Jul;3(3):234–250. doi: 10.1016/0013-9351(70)90019-8. [DOI] [PubMed] [Google Scholar]
  22. Staszewski J. Cancer of the kidney: international mortality patterns and trends. World Health Stat Q. 1980;33(1):42–55. [PubMed] [Google Scholar]
  23. Thomas T. L., Decoufle P., Moure-Eraso R. Mortality among workers employed in petroleum refining and petrochemical plants. J Occup Med. 1980 Feb;22(2):97–103. doi: 10.1097/00043764-198002000-00007. [DOI] [PubMed] [Google Scholar]
  24. Thomas T. L., Waxweiler R. J., Moure-Eraso R., Itaya S., Fraumeni J. F., Jr Mortality patterns among workers in three Texas oil refineries. J Occup Med. 1982 Feb;24(2):135–141. [PubMed] [Google Scholar]
  25. Thériault G., Goulet L. A mortality study of oil refinery workers. J Occup Med. 1979 May;21(5):367–370. [PubMed] [Google Scholar]
  26. Wen C. P., Tsai S. P., McClellan W. A., Gibson R. L. Long-term mortality study of oil refinery workers. I. Mortality of hourly and salaried workers. Am J Epidemiol. 1983 Oct;118(4):526–542. doi: 10.1093/oxfordjournals.aje.a113658. [DOI] [PubMed] [Google Scholar]
  27. Wynder E. L., Mabuchi K., Whitmore W. F., Jr Epidemiology of adenocarcinoma of the kidney. J Natl Cancer Inst. 1974 Dec;53(6):1619–1634. [PubMed] [Google Scholar]

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