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. 1981 Oct;41:159–165. doi: 10.1289/ehp.8141159

Excess lung cancer risk in a synthetic chemicals plant.

R J Waxweiler, A H Smith, H Falk, H A Tyroler
PMCID: PMC1568860  PMID: 6277613

Abstract

A standardized mortality ratio of 1.49 for respiratory system cancer (42 observed deaths versus 28.2 expected, p less than 0.01) was observed among a cohort of 4806 males employed at a synthetic chemicals plant since its startup in 1942. Upon review of pathologic material, the excess was found to be limited to adenocarcinoma and large cell undifferentiated lung cancer. Many of the workers had been exposed to vinyl chloride, as well as to chlorinated solvents, poly(vinyl chloride) (PVC) dust, acrylates and acrylonitrile. To evaluate the association between lung cancer and occupational chemical exposures, detailed work histories for each cohort member were combined with exposure ratings for each of 19 chemicals for each job for each calendar year since 1942. A serially additive expected dose model was then constructed which compared the doses of the chemicals observed for the lung cancer cases to the doses expected based on subcohorts without lung cancer individually matched to the cases. PVC dust appeared to be the most likely etiologic agent (p = 0.037). Time trends of PVC dust exposure indicated a potential latent period of 5-16 years before death.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Auerbach O., Garfinkel L., Parks V. R. Histologic type of lung cancer in relation to smoking habits, year of diagnosis and sites of metastases. Chest. 1975 Apr;67(4):382–387. doi: 10.1378/chest.67.4.382. [DOI] [PubMed] [Google Scholar]
  2. Buffler P. A., Wood S., Eifler C., Suarez L., Kilian D. J. Mortality experience of workers in a vinyl chloride monomer production plant. J Occup Med. 1979 Mar;21(3):195–203. [PubMed] [Google Scholar]
  3. Byrén D., Engholm G., Englund A., Westerholm P. Mortality and cancer morbidity in a group of Swedish VCM and PCV production workers. Environ Health Perspect. 1976 Oct;17:167–170. doi: 10.1289/ehp.17-1475258. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Chiazze L., Jr, Nichols W. E., Wong O. Mortality among employees of PVC fabricators. J Occup Med. 1977 Sep;19(9):623–628. [PubMed] [Google Scholar]
  5. DOLL R., HILL A. B. MORTALITY IN RELATION TO SMOKING: TEN YEARS' OBSERVATIONS OF BRITISH DOCTORS. Br Med J. 1964 Jun 6;1(5396):1460–CONCL. doi: 10.1136/bmj.1.5396.1460. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Duck B. W., Carter J. T., Coombes E. J. Mortality study of workers in a polyvinyl-chloride production plant. Lancet. 1975 Dec 13;2(7946):1197–1199. doi: 10.1016/s0140-6736(75)92674-4. [DOI] [PubMed] [Google Scholar]
  7. Fox A. J., Collier P. F. Low mortality rates in industrial cohort studies due to selection for work and survival in the industry. Br J Prev Soc Med. 1976 Dec;30(4):225–230. doi: 10.1136/jech.30.4.225. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Fox A. J., Collier P. F. Mortality experience of workers exposed to vinyl chloride monomer in the manufacture of polyvinyl chloride in Great Britain. Br J Ind Med. 1977 Feb;34(1):1–10. doi: 10.1136/oem.34.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. HAENSZEL W., LOVELAND D. B., SIRKEN M. G. Lung-cancer mortality as related to residence and smoking histories. I. White males. J Natl Cancer Inst. 1962 Apr;28:947–1001. [PubMed] [Google Scholar]
  10. Nicholson W. J., Hammond E. C., Seidman H., Selikoff I. J. Mortality experience of a cohort of vinyl chloride-polyvinyl chloride workers. Ann N Y Acad Sci. 1975 Jan 31;246:225–230. doi: 10.1111/j.1749-6632.1975.tb51096.x. [DOI] [PubMed] [Google Scholar]
  11. Ott M. G., Langer R. R., Holder B. B. Vinyl chloride exposure in a controlled industrial environment. A long-term mortality experience in 594 employees. Arch Environ Health. 1975 Jul;30(7):333–339. doi: 10.1080/00039896.1975.10666716. [DOI] [PubMed] [Google Scholar]
  12. Sterling T. D., Weinkam J. J. Smoking characteristics by type of employment. J Occup Med. 1976 Nov;18(11):743–754. doi: 10.1097/00043764-197611000-00011. [DOI] [PubMed] [Google Scholar]
  13. Szende B., Lapis K., Nemes A., Pinter A. Pneumoconiosis caused by the inhalation of polyvinylchloride dust. Med Lav. 1970 Aug-Sep;61(8):433–436. [PubMed] [Google Scholar]
  14. Thomas L. B., Popper H., Berk P. D., Selikoff I., Falk H. Vinyl-chloride-induced liver disease. From idiopathic portal hypertension (Banti's syndrome) to Angiosarcomas. N Engl J Med. 1975 Jan 2;292(1):17–22. doi: 10.1056/NEJM197501022920104. [DOI] [PubMed] [Google Scholar]
  15. Waxweiler R. J., Stringer W., Wagoner J. K., Jones J., Falk H., Carter C. Neoplastic risk among workers exposed to vinyl chloride. Ann N Y Acad Sci. 1976;271:40–48. doi: 10.1111/j.1749-6632.1976.tb23091.x. [DOI] [PubMed] [Google Scholar]
  16. Weiss W., Boucot K. R., Seidman H., Carnahan W. J. Risk of lung cancer according to histologic type and cigarette dosage. JAMA. 1972 Nov 13;222(7):799–801. [PubMed] [Google Scholar]
  17. Yesner R., Gelfman N. A., Feinstein A. R. A reappraisal of histopathology in lung cancer and correlation of cell types with antecedent cigarette smoking. Am Rev Respir Dis. 1973 May;107(5):790–797. doi: 10.1164/arrd.1973.107.5.790. [DOI] [PubMed] [Google Scholar]

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