Abstract
This paper presents a short review of the available carcinogenicity tests which have been carried out on various phthalate esters prior to the availability of the National Cancer Institute bioassay studies. All of these studies suffer from diverse limitations in design or reporting when compared to more recent experimental protocols and reports. There are three papers related to di(2-ethylhexyl) phthalate, one to di-n-butyl phthalate, two to butyl benzyl phthalate, one to ethyl phthalyl ethyl glycolate nd another to butyl phthalylbutyl glycolate (1).
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- CARPENTER C. P., WEIL C. S., SMYTH H. F., Jr Chronic oral toxicity of di-(2-ethylhexyl) phthalate of rats, guinea pigs, and dogs. AMA Arch Ind Hyg Occup Med. 1953 Sep;8(3):219–226. [PubMed] [Google Scholar]
- HARRIS R. S., HODGE H. C., MAYNARD E. A., BLANCHET H. J., Jr Chronic oral toxicity of 2-ethylhexyl phthalate in rats and dogs. AMA Arch Ind Health. 1956 Mar;13(3):259–264. [PubMed] [Google Scholar]
- HODGE H. C., MAYNARD E. A., BLANCHET H. J., Jr, HYATT R. E., ROWE V. K., SPENCER H. C. Chronic oral toxicity of ethyl phthalyl ethyl glycolate in rats and dogs. AMA Arch Ind Hyg Occup Med. 1953 Sep;8(3):289–295. [PubMed] [Google Scholar]
- Omori Y. Recent progress in safety evaluation studies on plasticizers and plastics and their controlled use in Japan. Environ Health Perspect. 1976 Oct;17:203–209. doi: 10.1289/ehp.7617203. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Theiss J. C., Stoner G. D., Shimkin M. B., Weisburger E. K. Test for carcinogenicity of organic contaminants of United States drinking waters by pulmonary tumor response in strain A mice. Cancer Res. 1977 Aug;37(8 Pt 1):2717–2720. [PubMed] [Google Scholar]