Abstract
There has been great public concern about the adverse health effects resulting from the presence of asbestos fibers in municipal drinking water supplies. This article reviews and summarizes the experimental findings of 11 published papers that have evaluated the carcinogenic potential of asbestos following its ingestion. The long-term, high-level ingestion of various types of asbestos fibers in more than one animal species failed to produce any definite, reproducible, organ-specific carcinogenic effect.
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Selected References
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- Bolton R. E., Davis J. M., Lamb D. The pathological effects of prolonged asbestos ingestion in rats. Environ Res. 1982 Oct;29(1):134–150. doi: 10.1016/0013-9351(82)90014-7. [DOI] [PubMed] [Google Scholar]
- Cook P. M., Glass G. E., Tucker J. H. Asbestiform amphibole minerals: detection and measurement of high concentrations in municipal water supplies. Science. 1974 Sep 6;185(4154):853–855. doi: 10.1126/science.185.4154.853. [DOI] [PubMed] [Google Scholar]
- Cunningham H. M., Moodie C. A., Lawrence G. A., Pontefract R. D. Chronic effects of ingested asbestos in rats. Arch Environ Contam Toxicol. 1977;6(4):507–513. doi: 10.1007/BF02097789. [DOI] [PubMed] [Google Scholar]
- Donham K. J., Berg J. W., Will L. A., Leininger J. R. The effects of long-term ingestion of asbestos on the colon of F344 rats. Cancer. 1980 Mar 15;45(5 Suppl):1073–1084. doi: 10.1002/1097-0142(19800315)45:5+<1073::aid-cncr2820451308>3.0.co;2-w. [DOI] [PubMed] [Google Scholar]
- Gibel W., Lohs K., Horn K. H., Wildner G. P., Hoffmann F. Tierexperimentelle Untersuchungen über eine kanzerogene Wirkung von Asbestfiltermaterial nach oraler Aufnahme. Arch Geschwulstforsch. 1976;46(6):437–442. [PubMed] [Google Scholar]
- Gross P., DeTreville R. T., Tolker E. B., Kaschak M., Babyak M. A. Experimental asbestosis. The development of lung cancer in rats with pulmonary deposits of chrysotile asbestos dust. Arch Environ Health. 1967 Sep;15(3):343–355. doi: 10.1080/00039896.1967.10664930. [DOI] [PubMed] [Google Scholar]
- Gross P., Harley R. A., Swinburne L. M., Davis J. M., Greene W. B. Ingested mineral fibers. Do they penetrate tissue or cause cancer? Arch Environ Health. 1974 Dec;29(6):341–347. doi: 10.1080/00039896.1974.10666612. [DOI] [PubMed] [Google Scholar]
- Hilding A. C., Hilding D. A., Larson D. M., Aufderheide A. C. Biological effects of ingested amosite asbestos, taconite tailings, diatomaceous earth and Lake Superior water in rats. Arch Environ Health. 1981 Nov-Dec;36(6):298–303. doi: 10.1080/00039896.1981.10667641. [DOI] [PubMed] [Google Scholar]
- Smith W. E., Hubert D. D., Sobel H. J., Peters E. T., Doerfler T. E. Health of experimental animals drinking water with and without amosite asbestos and other mineral particles. J Environ Pathol Toxicol. 1980 Jun-Jul;3(5-6):277–300. [PubMed] [Google Scholar]
- Wagner J. C., Berry G., Skidmore J. W., Timbrell V. The effects of the inhalation of asbestos in rats. Br J Cancer. 1974 Mar;29(3):252–269. doi: 10.1038/bjc.1974.65. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ward J. M. Dose response to a single injection of azoxymethane in rats. Induction of tumors in the gastrointestinal tract, auditory sebaceous glands, kidney, liver and preputial gland. Vet Pathol. 1975;12(3):165–177. doi: 10.1177/030098587501200302. [DOI] [PubMed] [Google Scholar]
- Ward J. M., Frank A. L., Wenk M., Devor D., Tarone R. E. Ingested asbestos and intestinal carcinogenesis in F344 rats. J Environ Pathol Toxicol. 1980 Jun-Jul;3(5-6):301–312. [PubMed] [Google Scholar]
- Webster I. The ingestion of asbestos fibers. Environ Health Perspect. 1974 Dec;9:199–202. doi: 10.1289/ehp.749199. [DOI] [PMC free article] [PubMed] [Google Scholar]