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. 1983 Sep;51:119–124. doi: 10.1289/ehp.8351119

Fibroblast RNA and macrophage proteins (including the fibrogenic factor) in experimental silicosis.

E Kulonen, M Aalto, S Aho, P Lehtinen, M Potila
PMCID: PMC1569280  PMID: 6196186

Abstract

A hypothesis is presented for the action of silica-treated macrophages on protein synthesis in fibroblasts and also a method for the isolation of silica-attached materials in lung tissue. The increased protein synthesis in the fibroblasts is due, at least partly, to an increase in mRNA. Silica prevents the suppressing "macrophage effect" of macrophage-originated ribonuclease on fibroblasts. However, under certain conditions, collagen synthesis is stimulated by silica-treated macrophage preparations to such an extent that the effect cannot be explained by the inhibition of macrophage ribonuclease alone. We therefore postulate the existence of a fibrogenic factor, which is released by the macrophages. This factor has been demonstrated and can be purified from lung homogenate of SiO2-treated rats.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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