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. 1983 Oct;52:61–66. doi: 10.1289/ehp.835261

Toxicity of vinyl chloride and poly(vinyl chloride): a critical review.

J K Wagoner
PMCID: PMC1569348  PMID: 6360677

Abstract

In 1974, vinyl chloride (VC) was first reported in the open scientific literature to induce angiosarcoma of the liver both in humans and in animals. Additional research has now demonstrated the carcinogenicity of VC to other organs and at lower concentrations. The target organs for VC now clearly include the liver, brain and the lung, and probably the lymphohematopoietic system. The evidence for a carcinogenic risk has been extended to jobs associated with poly(vinyl chloride) exposure. Cases of liver angiosarcoma have been reported among individuals employed in PVC fabrication facilities and an epidemiological study has demonstrated a significant association between exposure to PVC dust and the risk of lung cancer mortality. Cases of angiosarcoma of the liver also have been reported among individuals living in near proximity to vinyl chloride-poly(vinyl chloride) plants. An association between PVC dust and pneumoconiosis also has been demonstrated. On the basis of findings, prudent control of PVC dust in the industrial setting is indicated.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Agarwal D. K., Kaw J. L., Srivastava S. P., Seth P. K. Some biochemical and histopathological changes induced by polyvinyl chloride dust in rat lung. Environ Res. 1978 Jul;16(1-3):333–341. doi: 10.1016/0013-9351(78)90166-4. [DOI] [PubMed] [Google Scholar]
  2. Arnaud A., Pommier de Santi P. P., Garbe L., Payan H., Charpin J. Polyvinyl chloride pneumoconiosis. Thorax. 1978 Feb;33(1):19–25. doi: 10.1136/thx.33.1.19. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Baxter P. J., Anthony P. P., MacSween R. N., Scheuer P. J. Angiosarcoma of the liver in Great Britain, 1963-73. Br Med J. 1977 Oct 8;2(6092):919–921. doi: 10.1136/bmj.2.6092.919. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Brady J., Liberatore F., Harper P., Greenwald P., Burnett W., Davies J. N., Bishop M., Polan A., Vianna N. Angiosarcoma of the liver: an epidemiologic survey. J Natl Cancer Inst. 1977 Nov;59(5):1383–1385. doi: 10.1093/jnci/59.5.1383. [DOI] [PubMed] [Google Scholar]
  5. Byrén D., Engholm G., Englund A., Westerholm P. Mortality and cancer morbidity in a group of Swedish VCM and PCV production workers. Environ Health Perspect. 1976 Oct;17:167–170. doi: 10.1289/ehp.17-1475258. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Duck B. W., Carter J. T., Coombes E. J. Mortality study of workers in a polyvinyl-chloride production plant. Lancet. 1975 Dec 13;2(7946):1197–1199. doi: 10.1016/s0140-6736(75)92674-4. [DOI] [PubMed] [Google Scholar]
  7. Fox A. J., Collier P. F. Mortality experience of workers exposed to vinyl chloride monomer in the manufacture of polyvinyl chloride in Great Britain. Br J Ind Med. 1977 Feb;34(1):1–10. doi: 10.1136/oem.34.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Holmberg B., Kronevi T., Winell M. The pathology of vinyl chloride exposed mice. Acta Vet Scand. 1976;17(3):328–342. doi: 10.1186/BF03547913. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. KURLAND L. T., FARO S. N., SIEDLER H. Minamata disease. The outbreak of a neurologic disorder in Minamata, Japan, and its relationship to the ingestion of seafood contaminated by mercuric compounds. World Neurol. 1960 Nov;1:370–395. [PubMed] [Google Scholar]
  10. Keplinger M. L., Goode J. W., Gordon D. E., Calandra J. C. Interim results of exposure of rats, hamsters, and mice to vinyl chloride. Ann N Y Acad Sci. 1975 Jan 31;246:219–224. doi: 10.1111/j.1749-6632.1975.tb51095.x. [DOI] [PubMed] [Google Scholar]
  11. Lilis R., Anderson H., Nicholson W. J., Daum S., Fischbein A. S., Selikoff I. J. Prevalence of disease among vinyl chloride and polyvinyl chloride workers. Ann N Y Acad Sci. 1975 Jan 31;246:22–41. doi: 10.1111/j.1749-6632.1975.tb51078.x. [DOI] [PubMed] [Google Scholar]
  12. Maltoni C., Lefemine G. Carcinogenicity bioassays of vinyl chloride: current results. Ann N Y Acad Sci. 1975 Jan 31;246:195–218. doi: 10.1111/j.1749-6632.1975.tb51094.x. [DOI] [PubMed] [Google Scholar]
  13. Maltoni C. Occupational carcinogenesis. Predictive value of carcinogenesis bioassays. Ann N Y Acad Sci. 1976;271:431–443. doi: 10.1111/j.1749-6632.1976.tb23144.x. [DOI] [PubMed] [Google Scholar]
  14. Mastrangelo G., Manno M., Marcer G., Bartolucci G. B., Gemignani C., Saladino G., Simonato L., Saia B. Polyvinyl chloride pneumoconiosis: epidemiological study of exposed workers. J Occup Med. 1979 Aug;21(8):540–542. [PubMed] [Google Scholar]
  15. Miller A., Teirstein A. S., Chuang M., Selikoff I. J., Warshaw R. Changes in pulmonary function in workers exposed to vinyl chloride and polyvinyl chloride. Ann N Y Acad Sci. 1975 Jan 31;246:42–52. doi: 10.1111/j.1749-6632.1975.tb51079.x. [DOI] [PubMed] [Google Scholar]
  16. Monson R. R., Peters J. M., Johnson M. N. Proportional mortality among vinyl-chloride workers. Lancet. 1974 Aug 17;2(7877):397–398. doi: 10.1016/s0140-6736(74)91771-1. [DOI] [PubMed] [Google Scholar]
  17. Nicholson W. J., Hammond E. C., Seidman H., Selikoff I. J. Mortality experience of a cohort of vinyl chloride-polyvinyl chloride workers. Ann N Y Acad Sci. 1975 Jan 31;246:225–230. doi: 10.1111/j.1749-6632.1975.tb51096.x. [DOI] [PubMed] [Google Scholar]
  18. Ott M. G., Langer R. R., Holder B. B. Vinyl chloride exposure in a controlled industrial environment. A long-term mortality experience in 594 employees. Arch Environ Health. 1975 Jul;30(7):333–339. doi: 10.1080/00039896.1975.10666716. [DOI] [PubMed] [Google Scholar]
  19. Szende B., Lapis K., Nemes A., Pinter A. Pneumoconiosis caused by the inhalation of polyvinylchloride dust. Med Lav. 1970 Aug-Sep;61(8):433–436. [PubMed] [Google Scholar]
  20. TOKELSON T. R., OYEN F., ROWE V. K. The toxicity of vinyl chloride as determined by repeated exposure of laboratory animals. Am Ind Hyg Assoc J. 1961 Oct;22:354–361. doi: 10.1080/00028896109343421. [DOI] [PubMed] [Google Scholar]
  21. Tabershaw I. R., Gaffey W. R. Mortality study of workers in the manufacture of vinyl chloride and its polymers. J Occup Med. 1974 Aug;16(8):509–518. [PubMed] [Google Scholar]
  22. Viola P. L., Bigotti A., Caputo A. Oncogenic response of rat skin, lungs, and bones to vinyl chloride. Cancer Res. 1971 May;31(5):516–522. [PubMed] [Google Scholar]
  23. Wagoner J. K., Infante P. F., Saracci R. Vinyl chloride and mortality? Lancet. 1976 Jul 24;2(7978):194–195. doi: 10.1016/s0140-6736(76)92361-8. [DOI] [PubMed] [Google Scholar]
  24. Waxweiler R. J., Stringer W., Wagoner J. K., Jones J., Falk H., Carter C. Neoplastic risk among workers exposed to vinyl chloride. Ann N Y Acad Sci. 1976;271:40–48. doi: 10.1111/j.1749-6632.1976.tb23091.x. [DOI] [PubMed] [Google Scholar]

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