Skip to main content
PMC home page
British Journal of Pharmacology and Chemotherapy logoLink to British Journal of Pharmacology and Chemotherapy
. 1968 Jan;32(1):1–16. doi: 10.1111/j.1476-5381.1968.tb00423.x

Metabolism, transfer and storage of 5-hydroxytryptamine in blood platelets.

A Pletscher
PMCID: PMC1570304  PMID: 4870578

Full text

PDF
13

Images in this article

3Fig. 2
on p.3
8Fig. 6
on p.8
12Fig. 8
on p.12

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BARTHOLINI G., DAPRADA M., PLETSCHER A. INHIBITION OF 5-HYDROXYTRYPTAMINE LIBERATION FROM BLOOD PLATELETS BY RESERPINE. Nature. 1965 Jan 23;205:400–401. doi: 10.1038/205400a0. [DOI] [PubMed] [Google Scholar]
  2. BARTHOLINI G., PLETSCHER A., BRUDERER H. DECOMPOSITION OF DILUTE HYDROGEN PEROXIDE IN ALKALINE SOLUTIONS. Nature. 1964 Sep 19;203:1281–1283. doi: 10.1038/2031281b0. [DOI] [PubMed] [Google Scholar]
  3. BARTHOLINI G., PLETSCHER A., GEY K. F. Diminution of 5-hydroxytryptamine in thrombocytes in vitro by chlorpromazine and related compounds. Experientia. 1961 Dec 15;17:541–542. doi: 10.1007/BF02156407. [DOI] [PubMed] [Google Scholar]
  4. BORN G. V., BRICKNELL J. The uptake of 5-hydroxytryptamine by blood platelets in the cold. J Physiol. 1959 Jun 23;147(1):153–161. doi: 10.1113/jphysiol.1959.sp006230. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. BORN G. V., GILLSON R. E. Studies on the uptake of 5-hydroxytryptamine by blood platelets. J Physiol. 1959 Jun 11;146(3):472–491. doi: 10.1113/jphysiol.1959.sp006206. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. BORN G. V., INGRAM G. I., STACEY R. S. The relationship between 5-hydroxytryptamine and adenosine triphosphate in blood platelets. Br J Pharmacol Chemother. 1958 Mar;13(1):62–64. doi: 10.1111/j.1476-5381.1958.tb00191.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. BORRELLI J., ZUCKER M. B. Absorption of serotonin (5-hydroxytryptamine) by canine and human platelets. Am J Physiol. 1956 Jul;186(1):105–110. doi: 10.1152/ajplegacy.1956.186.1.105. [DOI] [PubMed] [Google Scholar]
  8. BRODIE B. B., TOMICH E. G., KUNTZMAN R., SHORE P. A. On the mechanism of action of reserpine: effect of reserpine on capacity of tissues to bind serotonin. J Pharmacol Exp Ther. 1957 Apr;119(4):461–467. [PubMed] [Google Scholar]
  9. Bartholini G., Pletscher A. Two types of 5-hydroxytryptamine release from isolated blood platelets. Experientia. 1964 Jul 15;20(7):376–378. doi: 10.1007/BF02147970. [DOI] [PubMed] [Google Scholar]
  10. Carlsson A. Modification of sympathetic function. Pharmacological depletion of catecholamine stores. Pharmacol Rev. 1966 Mar;18(1):541–549. [PubMed] [Google Scholar]
  11. Da Prada M., Bartholini G., Pletscher A. Effect of monoamine liberators on the metabolism of 5-hydroxytryptamine in blood platelets. Biochem Pharmacol. 1965 Dec;14(12):1721–1726. doi: 10.1016/0006-2952(65)90261-3. [DOI] [PubMed] [Google Scholar]
  12. Da Prada M., Pletscher A., Bartholini G. Temperature sensitivity of the passive outflow of 5-hydroxytryptamine from blood platelets. Life Sci. 1965 Sep;4(18):1773–1778. doi: 10.1016/0024-3205(65)90239-0. [DOI] [PubMed] [Google Scholar]
  13. FUKS Z., LANMAN R. C., SCHANKER L. S. ON THE MEMBRANE EFFECTS OF CHLORPROMAZINE: UPTAKE OF BIOLOGIC AMINES BY THE BLOOD PLATELET AND RED CELL. Int J Neuropharmacol. 1964 Dec;3:623–633. doi: 10.1016/0028-3908(64)90087-5. [DOI] [PubMed] [Google Scholar]
  14. HARDISTY R. M., STACEY R. S. 5-Hydroxytryptamine in normal human platelets. J Physiol. 1955 Dec 29;130(3):711–720. doi: 10.1113/jphysiol.1955.sp005437. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. HUGHES F. B., BRODIE B. B. The mechanism of serotonin and catecholamine uptake by platelets. J Pharmacol Exp Ther. 1959 Oct;127:96–102. [PubMed] [Google Scholar]
  16. HUMPHREY J. H., TOH C. C. Absorption of serotonin (5-hydroxytryptamine) and histamine by dog platelets. J Physiol. 1954 May 28;124(2):300–304. doi: 10.1113/jphysiol.1954.sp005108. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. MARSHALL E. F., STIRLING G. S., TAIT A. C., TODRICK A. The effect of iproniazid and imipramine on the blood platelet 5-hydroxytrptamine level in man. Br J Pharmacol Chemother. 1960 Mar;15:35–41. doi: 10.1111/j.1476-5381.1960.tb01207.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. PAASONEN M. K., PLETSCHER A. Increase of free 5-hydroxytryptamine in blood plasma by reserpine and a benzoquinolizine derivative. Experientia. 1959 Dec 15;15:477–479. doi: 10.1007/BF02158266. [DOI] [PubMed] [Google Scholar]
  19. PLETSCHER A., BARTHOLINI G. PHARMAKOLOGISCHE BEEINFLUSSUNG DER 5-HYDROXYTRYPTAMIN-FREISETZUNG AUS BLUTPLAETTCHEN. Helv Physiol Pharmacol Acta. 1964;22:C84–C86. [PubMed] [Google Scholar]
  20. Pletscher A., Burkard W. P., Tranzer J. P., Gey K. F. Two sites of 5-hydroxytryptamine uptake in blood platelets. Life Sci. 1967 Feb 1;6(3):273–280. doi: 10.1016/0024-3205(67)90156-7. [DOI] [PubMed] [Google Scholar]
  21. Pletscher A., Da Prada M., Bartholini G., Burkard W. P., Bruderer H. Two types of monoamine liberation by chlorinated aralkylamines. Life Sci. 1965 Dec;4(23):2301–2308. doi: 10.1016/0024-3205(65)90253-5. [DOI] [PubMed] [Google Scholar]
  22. Pletscher A., Da Prada M., Bartholini G. Temperature dependence of the passive in- and outflow of 5-hydroxytryptamine in blood platelets. Biochem Pharmacol. 1966 Apr;15(4):419–424. doi: 10.1016/0006-2952(66)90252-8. [DOI] [PubMed] [Google Scholar]
  23. Pletscher A., Da Prada M., Burkard W. P., Bartholini G., Steiner F. A., Bruderer H., Bigler F. Aralkylamines with different effects on the metabolism of aromatic monoamines. J Pharmacol Exp Ther. 1966 Oct;154(1):64–72. [PubMed] [Google Scholar]
  24. Pletscher A., Tranzer J. P. Action of reserpine and imipramine on intracellular storage of 5-hydroxytryptamine in blood platelets. Experientia. 1967 Apr 15;23(4):289–291. doi: 10.1007/BF02135693. [DOI] [PubMed] [Google Scholar]
  25. SANO I., KAKIMOTO Y., TANIGUCHI K. Binding and transport of serotonin in rabbit blood platelets and action of reserpine. Am J Physiol. 1958 Nov;195(2):495–498. doi: 10.1152/ajplegacy.1958.195.2.495. [DOI] [PubMed] [Google Scholar]
  26. WEISSBACH H., REDFIELD B. G. Factors affecting the uptake of 5-hydroxytryptamine by human platelets in an inorganic medium. J Biol Chem. 1960 Nov;235:3287–3291. [PubMed] [Google Scholar]
  27. Weber E., Mondt H. Verteilung und Beeinflussung von Metaboliten in fraktionierten Homogenaten aus Blutplättchen. Klin Wochenschr. 1967 Feb 1;45(3):165–166. doi: 10.1007/BF01725077. [DOI] [PubMed] [Google Scholar]
  28. da Prada M., Bartholini G., Pletscher A. Formation of 5-hydroxytryptophol by blood platelets after thrombin and reserpine. Experientia. 1965 Mar 15;21(3):135–136. doi: 10.1007/BF02141975. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Pharmacology and Chemotherapy are provided here courtesy of The British Pharmacological Society

RESOURCES