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. 1984 Oct;58(1):57–62.

Distribution of IgG subclasses in membranous nephropathy.

T Doi, M Mayumi, K Kanatsu, F Suehiro, Y Hamashima
PMCID: PMC1576972  PMID: 6383668

Abstract

The distribution of human IgG subclasses among the glomerular deposits in human membranous nephropathy was examined by immunofluorescence with subclass specific monoclonal antibodies. Large amounts of granular deposits of IgG4 were identified along the capillary loops in all 12 patients, and seven patients had small amounts of IgG1 deposits. Neither IgG2 nor IgG3 deposits were detectable in any of the patients. On the contrary, all four IgG subclasses were detected in membranoproliferative glomerulonephritis and lupus nephritis with a predominance of IgG1 and IgG3. The results indicate that IgG4 is predominant in the glomerular deposits in membranous nephropathy and may play an important role in its pathogenesis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bannister K. M., Howarth G. S., Clarkson A. R., Woodroffe A. J. Glomerular IgG subclass distribution in human glomerulonephritis. Clin Nephrol. 1983 Apr;19(4):161–165. [PubMed] [Google Scholar]
  2. Brenner B. M., Hostetter T. H., Humes H. D. Molecular basis of proteinuria of glomerular origin. N Engl J Med. 1978 Apr 13;298(15):826–833. doi: 10.1056/NEJM197804132981507. [DOI] [PubMed] [Google Scholar]
  3. Cameron J. S. Pathogenesis and treatment of membranous nephropathy. Kidney Int. 1979 Jan;15(1):88–103. doi: 10.1038/ki.1979.12. [DOI] [PubMed] [Google Scholar]
  4. Couser W. G., Salant D. J. In situ immune complex formation and glomerular injury. Kidney Int. 1980 Jan;17(1):1–13. doi: 10.1038/ki.1980.1. [DOI] [PubMed] [Google Scholar]
  5. Dixon F. J. The pathogenesis of glomerulonephritis. Am J Med. 1968 Apr;44(4):493–498. doi: 10.1016/0002-9343(68)90050-8. [DOI] [PubMed] [Google Scholar]
  6. Fontaine M., Daveau M., Lebreton J. P., Dumouchel L., Vannier J. P., Godin M. Evidence that an autoantibody of IgG3 subclass against C3b discloses a C3 Nef activity in a pateint with partial lipodystrophy and glomerulonephritis. Ann Immunol (Paris) 1980 Jan-Feb;131C(1):39–53. [PubMed] [Google Scholar]
  7. GREY H. M., KUNKEL H. G. H CHAIN SUBGROUPS OF MYELOMA PROTEINS AND NORMAL 7S GAMMA-GLOBULIN. J Exp Med. 1964 Aug 1;120:253–266. doi: 10.1084/jem.120.2.253. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Gauthier V. J., Mannik M., Striker G. E. Effect of cationized antibodies in performed immune complexes on deposition and persistence in renal glomeruli. J Exp Med. 1982 Sep 1;156(3):766–777. doi: 10.1084/jem.156.3.766. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Götze O., Müller-Eberhard H. J. The C3-activator system: an alternate pathway of complement activation. J Exp Med. 1971 Sep 1;134(3 Pt 2):90s–108s. [PubMed] [Google Scholar]
  10. Ishizaka T., Ishizaka K., Salmon S., Fudenberg H. Biologic activities of aggregated gamma-globulin. 8. Aggregated immunoglobulins of different classes. J Immunol. 1967 Jul;99(1):82–91. [PubMed] [Google Scholar]
  11. KUNKEL H. G., ALLEN J. C., GREY H. M., MARTENSSON L., GRUBB R. A RELATIONSHIP BETWEEN THE H CHAIN GROUPS OF 7S GAMMA-GLOBULIN AND THE GM SYSTEM. Nature. 1964 Jul 25;203:413–414. doi: 10.1038/203413a0. [DOI] [PubMed] [Google Scholar]
  12. Kunkel H. G., Yount W. J., Litwin S. D. Genetically determined antigen of the Ne subgroup of gamma-globulin: detection by precipitin analysis. Science. 1966 Nov 25;154(3752):1041–1043. doi: 10.1126/science.154.3752.1041. [DOI] [PubMed] [Google Scholar]
  13. Lewis E. J., Busch G. J., Schur P. H. Gamma G globulin subgroup composition of the glomerular deposits in human renal diseases. J Clin Invest. 1970 Jun;49(6):1103–1113. doi: 10.1172/JCI106326. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Lowe J., Bird P., Hardie D., Jefferis R., Ling N. R. Monoclonal antibodies (McAbs) to determinants on human gamma chains: properties of antibodies showing subclass restriction or subclass specificity. Immunology. 1982 Oct;47(2):329–336. [PMC free article] [PubMed] [Google Scholar]
  15. Mayumi M., Kuritani T., Kubagawa H., Cooper M. D. IgG subclass expression by human B lymphocytes and plasma cells: B lymphocytes precommitted to IgG subclass can be preferentially induced by polyclonal mitogens with T cell help. J Immunol. 1983 Feb;130(2):671–677. [PubMed] [Google Scholar]
  16. McCluskey R. T., Vassalli P., Gallo G., Baldwin D. S. An immunofluorescent study of pathogenic mechanisms in glomerular diseases. N Engl J Med. 1966 Mar 31;274(13):695–701. doi: 10.1056/NEJM196603312741301. [DOI] [PubMed] [Google Scholar]
  17. McPhaul J. J., Jr, Dixon F. J. Characterization of immunoglobulin G anti-glomerular basement membrane antibodies eluted from kidneys of patients with glomerulonephritis. II. IgG subtypes and in vitro complement fixation. J Immunol. 1971 Sep;107(3):678–684. [PubMed] [Google Scholar]
  18. Puritz E. M., Yount W. J., Newell M., Utsinger P. D. Immunoglobulin classes and IgG subclasses of human antinuclear antibodies. A correlation of complement fixation and the nephritis of systemic lupus erythematosus. Clin Immunol Immunopathol. 1973 Nov;2(1):98–113. doi: 10.1016/0090-1229(73)90040-8. [DOI] [PubMed] [Google Scholar]
  19. Roberts J. L., Wyatt R. J., Schwartz M. M., Lewis E. J. Differential characteristics of immune-bound antibodies in diffuse proliferative and membranous forms of lupus glomerulonephritis. Clin Immunol Immunopathol. 1983 Nov;29(2):223–241. doi: 10.1016/0090-1229(83)90026-0. [DOI] [PubMed] [Google Scholar]
  20. Spiegelberg H. L. Biological activities of immunoglobulins of different classes and subclasses. Adv Immunol. 1974;19(0):259–294. doi: 10.1016/s0065-2776(08)60254-0. [DOI] [PubMed] [Google Scholar]
  21. Yount W. J., Seligmann M., Hong R., Good R., Kunkel H. G. Imbalances of gamma globulin subgroups and gene defects in patients with primary hypogammaglobulinemia. J Clin Invest. 1970 Nov;49(11):1957–1966. doi: 10.1172/JCI106415. [DOI] [PMC free article] [PubMed] [Google Scholar]

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